Matches in SemOpenAlex for { <https://semopenalex.org/work/W4317491723> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W4317491723 endingPage "152" @default.
- W4317491723 startingPage "149" @default.
- W4317491723 abstract "Interleukin-5 (IL-5) inhibitors have revolutionized the management of eosinophilic asthma. However, IL-5 is thought to play a protective role in atherosclerosis, and cardiovascular safety data for IL-5i are scarce. We used population-level data to examine the association between genetically proxied IL-5i and the risk of cardiovascular diseases. Genetic instruments for IL-5i were selected from a genome-wide association study of eosinophil count in 563,946 individuals. Genetic association data for coronary artery disease were obtained from 60,801 cases, 40,585 stroke cases, 7988 venous thromboembolism cases, and up to 406,111 controls. We used the inverse-variance weighted method and a series of sensitivity analyses. Nine genetic variants were selected to instrument IL-5i. Genetically proxied IL-5i was not associated with the risk of coronary heart disease (OR 0.82, 95%CI 0.65–1.03), stroke (OR 1.10; 0.95–1.27), or venous thromboembolism (OR 0.87; 0.64–1.17). We found no genetic evidence to suggest that IL-5i affects the risk of adverse cardiovascular and thromboembolic events." @default.
- W4317491723 created "2023-01-20" @default.
- W4317491723 creator A5017716917 @default.
- W4317491723 creator A5032580711 @default.
- W4317491723 creator A5084274925 @default.
- W4317491723 date "2023-03-01" @default.
- W4317491723 modified "2023-10-14" @default.
- W4317491723 title "Cardiovascular safety of genetically proxied interleukin-5 inhibition: A mendelian randomization study" @default.
- W4317491723 cites W1966248894 @default.
- W4317491723 cites W1970648068 @default.
- W4317491723 cites W2103783427 @default.
- W4317491723 cites W2103916194 @default.
- W4317491723 cites W2141642131 @default.
- W4317491723 cites W2149049208 @default.
- W4317491723 cites W2238851414 @default.
- W4317491723 cites W2398690791 @default.
- W4317491723 cites W2791863121 @default.
- W4317491723 cites W2969485794 @default.
- W4317491723 cites W2985439294 @default.
- W4317491723 cites W2999230481 @default.
- W4317491723 cites W3081528139 @default.
- W4317491723 cites W3172857299 @default.
- W4317491723 doi "https://doi.org/10.1016/j.resinv.2022.12.004" @default.
- W4317491723 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36682083" @default.
- W4317491723 hasPublicationYear "2023" @default.
- W4317491723 type Work @default.
- W4317491723 citedByCount "1" @default.
- W4317491723 countsByYear W43174917232023 @default.
- W4317491723 crossrefType "journal-article" @default.
- W4317491723 hasAuthorship W4317491723A5017716917 @default.
- W4317491723 hasAuthorship W4317491723A5032580711 @default.
- W4317491723 hasAuthorship W4317491723A5084274925 @default.
- W4317491723 hasBestOaLocation W43174917231 @default.
- W4317491723 hasConcept C104317684 @default.
- W4317491723 hasConcept C106208931 @default.
- W4317491723 hasConcept C126322002 @default.
- W4317491723 hasConcept C127413603 @default.
- W4317491723 hasConcept C135763542 @default.
- W4317491723 hasConcept C153209595 @default.
- W4317491723 hasConcept C164705383 @default.
- W4317491723 hasConcept C2776042228 @default.
- W4317491723 hasConcept C2779134260 @default.
- W4317491723 hasConcept C2779901538 @default.
- W4317491723 hasConcept C2780645631 @default.
- W4317491723 hasConcept C2908647359 @default.
- W4317491723 hasConcept C2993967602 @default.
- W4317491723 hasConcept C54355233 @default.
- W4317491723 hasConcept C71924100 @default.
- W4317491723 hasConcept C78519656 @default.
- W4317491723 hasConcept C86803240 @default.
- W4317491723 hasConcept C99454951 @default.
- W4317491723 hasConceptScore W4317491723C104317684 @default.
- W4317491723 hasConceptScore W4317491723C106208931 @default.
- W4317491723 hasConceptScore W4317491723C126322002 @default.
- W4317491723 hasConceptScore W4317491723C127413603 @default.
- W4317491723 hasConceptScore W4317491723C135763542 @default.
- W4317491723 hasConceptScore W4317491723C153209595 @default.
- W4317491723 hasConceptScore W4317491723C164705383 @default.
- W4317491723 hasConceptScore W4317491723C2776042228 @default.
- W4317491723 hasConceptScore W4317491723C2779134260 @default.
- W4317491723 hasConceptScore W4317491723C2779901538 @default.
- W4317491723 hasConceptScore W4317491723C2780645631 @default.
- W4317491723 hasConceptScore W4317491723C2908647359 @default.
- W4317491723 hasConceptScore W4317491723C2993967602 @default.
- W4317491723 hasConceptScore W4317491723C54355233 @default.
- W4317491723 hasConceptScore W4317491723C71924100 @default.
- W4317491723 hasConceptScore W4317491723C78519656 @default.
- W4317491723 hasConceptScore W4317491723C86803240 @default.
- W4317491723 hasConceptScore W4317491723C99454951 @default.
- W4317491723 hasFunder F4320319990 @default.
- W4317491723 hasFunder F4320327444 @default.
- W4317491723 hasIssue "2" @default.
- W4317491723 hasLocation W43174917231 @default.
- W4317491723 hasLocation W43174917232 @default.
- W4317491723 hasOpenAccess W4317491723 @default.
- W4317491723 hasPrimaryLocation W43174917231 @default.
- W4317491723 hasRelatedWork W2921863175 @default.
- W4317491723 hasRelatedWork W3006234351 @default.
- W4317491723 hasRelatedWork W3135100251 @default.
- W4317491723 hasRelatedWork W3200223957 @default.
- W4317491723 hasRelatedWork W4224254345 @default.
- W4317491723 hasRelatedWork W4245210919 @default.
- W4317491723 hasRelatedWork W4319459798 @default.
- W4317491723 hasRelatedWork W4322724676 @default.
- W4317491723 hasRelatedWork W4383720502 @default.
- W4317491723 hasRelatedWork W4386708907 @default.
- W4317491723 hasVolume "61" @default.
- W4317491723 isParatext "false" @default.
- W4317491723 isRetracted "false" @default.
- W4317491723 workType "article" @default.