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- W4317494065 abstract "Drug-related liver injury (DILI) is increasing in the incidence of liver injury due to nonviral liver disease and has become a health problem that should not be underestimated. As a hot research topic in recent years, gut microbiota have been studied in various tumors, cardiovascular metabolic diseases, and human immunity. However, there is still a lack of research related to gut microbiota and DILI. It is known that they can influence each other through the regulation of the “gut-liver axis,” and the relationship between them and the possible mechanisms of action are still at the research stage. Human leukocyte antigen (HLA) gene polymorphisms are closely related to the development of DILI, and the gene can also affect changes in the composition of gut microbes. In this paper, we review the possible relationships and mechanisms between DILI and gut microbiota in order to provide new research directions for the prevention and treatment of DILI in the future. In the future, untargeted therapies using antibiotics, probiotics, or FMT will be replaced by personalised and precision medicine approaches, such as bioengineered bacterial strains or drugs that modulate specific bacterial enzymes and metabolic pathways." @default.
- W4317494065 created "2023-01-20" @default.
- W4317494065 creator A5006603724 @default.
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- W4317494065 creator A5014942240 @default.
- W4317494065 creator A5049320370 @default.
- W4317494065 creator A5066744436 @default.
- W4317494065 creator A5074260658 @default.
- W4317494065 date "2023-01-19" @default.
- W4317494065 modified "2023-10-12" @default.
- W4317494065 title "Gut Microbiota and Drug-Related Liver Injury: Challenges and Perspectives" @default.
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