FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4317494997> ?p ?o ?g. }

• W4317494997 abstract "Abstract Background Spondyloarthritis (SpA) is a chronic inflammatory disease that results in bone ankylosis. The tissue renin-angiotensin system (RAS), updated with new components, is an emerging phenomenon possibly implicated in SpA-associated bone changes. Therefore, we sought to determine the mechanism underlying this relationship. Methods Sakaguchi (SKG) mice injected with curdlan (SKGc), animal models for SpA, were treated with the RAS modulators, angiotensin II receptor blockers (ARBs) or angiotensin-converting enzyme inhibitors (ACEis). Disease activity was assessed using clinical scores and computed tomography scans. Mouse primary bone marrow monocytes (BMMs), osteoblast (OB) progenitor cells, peripheral blood monocytes (PBMCs), and bone-derived cells (BdCs) from patients with radiographic axial SpA (r-axSpA) were used to investigate the role of RAS in SpA pathogenesis. Results The expression of RAS components was significantly high in SKGc mouse joints, wherein ARBs significantly reduced erosion and systemic bone loss, whereas ACEis did not. Osteoclast (OC) differentiation from primary BMMs, mediated by TRAF6, was inhibited by ARBs but promoted by ACEis; the modulators also exerted opposite effects on OB differentiation. Expression of RAS molecules was higher in PBMCs and BdCs of patients with r-axSpA than in control participants. ARBs inhibited OB differentiation in the BdCs of patients with r-axSpA, whereas ACEi did not. Neither ARBs nor ACEis affected OB differentiation in the control participants. Conclusions In SpA, a condition characterized by RAS overexpression, ARBs, but not ACEis, inhibited OC and OB differentiation and bone progression. These findings must be considered when treating patients with SpA using RAS modulators." @default.
• W4317494997 created "2023-01-20" @default.
• W4317494997 creator A5015846991 @default.
• W4317494997 creator A5020141437 @default.
• W4317494997 creator A5026216541 @default.
• W4317494997 creator A5035908453 @default.
• W4317494997 creator A5037760893 @default.
• W4317494997 creator A5040464998 @default.
• W4317494997 creator A5041792310 @default.
• W4317494997 creator A5043598281 @default.
• W4317494997 creator A5051212046 @default.
• W4317494997 creator A5063577300 @default.
• W4317494997 date "2023-01-19" @default.
• W4317494997 modified "2023-09-27" @default.
• W4317494997 title "Angiotensin receptor blockers, but not angiotensin-converting enzyme inhibitors, inhibit abnormal bone changes in spondyloarthritis" @default.
• W4317494997 cites W1001028985 @default.
• W4317494997 cites W1495554157 @default.
• W4317494997 cites W1517723367 @default.
• W4317494997 cites W1592232168 @default.
• W4317494997 cites W180946569 @default.
• W4317494997 cites W1955943376 @default.
• W4317494997 cites W1993123529 @default.
• W4317494997 cites W2008614129 @default.
• W4317494997 cites W2021400723 @default.
• W4317494997 cites W2024594848 @default.
• W4317494997 cites W2044773944 @default.
• W4317494997 cites W2052265065 @default.
• W4317494997 cites W2056976690 @default.
• W4317494997 cites W2064898327 @default.
• W4317494997 cites W2069893575 @default.
• W4317494997 cites W2074187263 @default.
• W4317494997 cites W2078428843 @default.
• W4317494997 cites W2105940680 @default.
• W4317494997 cites W2113832063 @default.
• W4317494997 cites W2157466080 @default.
• W4317494997 cites W2337855427 @default.
• W4317494997 cites W2469805673 @default.
• W4317494997 cites W2522381157 @default.
• W4317494997 cites W2528583551 @default.
• W4317494997 cites W2585608783 @default.
• W4317494997 cites W2615684303 @default.
• W4317494997 cites W2780715796 @default.
• W4317494997 cites W2796291251 @default.
• W4317494997 cites W2807518326 @default.
• W4317494997 cites W2972986412 @default.
• W4317494997 cites W3001952709 @default.
• W4317494997 cites W3024339709 @default.
• W4317494997 cites W3035051154 @default.
• W4317494997 cites W3046613505 @default.
• W4317494997 cites W3081015617 @default.
• W4317494997 cites W3104092741 @default.
• W4317494997 cites W3127767345 @default.
• W4317494997 cites W4210974969 @default.
• W4317494997 cites W4211203343 @default.
• W4317494997 doi "https://doi.org/10.21203/rs.3.rs-2482526/v1" @default.
• W4317494997 hasPublicationYear "2023" @default.
• W4317494997 type Work @default.
• W4317494997 citedByCount "0" @default.
• W4317494997 crossrefType "posted-content" @default.
• W4317494997 hasAuthorship W4317494997A5015846991 @default.
• W4317494997 hasAuthorship W4317494997A5020141437 @default.
• W4317494997 hasAuthorship W4317494997A5026216541 @default.
• W4317494997 hasAuthorship W4317494997A5035908453 @default.
• W4317494997 hasAuthorship W4317494997A5037760893 @default.
• W4317494997 hasAuthorship W4317494997A5040464998 @default.
• W4317494997 hasAuthorship W4317494997A5041792310 @default.
• W4317494997 hasAuthorship W4317494997A5043598281 @default.
• W4317494997 hasAuthorship W4317494997A5051212046 @default.
• W4317494997 hasAuthorship W4317494997A5063577300 @default.
• W4317494997 hasBestOaLocation W43174949971 @default.
• W4317494997 hasConcept C126322002 @default.
• W4317494997 hasConcept C134018914 @default.
• W4317494997 hasConcept C137061746 @default.
• W4317494997 hasConcept C170033053 @default.
• W4317494997 hasConcept C170493617 @default.
• W4317494997 hasConcept C185592680 @default.
• W4317494997 hasConcept C198710026 @default.
• W4317494997 hasConcept C201750760 @default.
• W4317494997 hasConcept C202751555 @default.
• W4317494997 hasConcept C27016395 @default.
• W4317494997 hasConcept C2776033226 @default.
• W4317494997 hasConcept C2778260815 @default.
• W4317494997 hasConcept C2780007613 @default.
• W4317494997 hasConcept C2780942790 @default.
• W4317494997 hasConcept C28328180 @default.
• W4317494997 hasConcept C55493867 @default.
• W4317494997 hasConcept C71924100 @default.
• W4317494997 hasConcept C84393581 @default.
• W4317494997 hasConcept C86803240 @default.
• W4317494997 hasConcept C95444343 @default.
• W4317494997 hasConcept C98274493 @default.
• W4317494997 hasConceptScore W4317494997C126322002 @default.
• W4317494997 hasConceptScore W4317494997C134018914 @default.
• W4317494997 hasConceptScore W4317494997C137061746 @default.
• W4317494997 hasConceptScore W4317494997C170033053 @default.
• W4317494997 hasConceptScore W4317494997C170493617 @default.
• W4317494997 hasConceptScore W4317494997C185592680 @default.
• W4317494997 hasConceptScore W4317494997C198710026 @default.
• W4317494997 hasConceptScore W4317494997C201750760 @default.
• W4317494997 hasConceptScore W4317494997C202751555 @default.

• next