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- W4317497429 abstract "HomeCirculation ResearchVol. 132, No. 2Finding Needles in the Gut Microbiota’s Haystack No AccessEditorialRequest AccessFull TextAboutView Full TextView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toNo AccessEditorialRequest AccessFull TextFinding Needles in the Gut Microbiota’s Haystack Michael Aljadah and Michael E. Widlansky Michael AljadahMichael Aljadah Division of Cardiovascular Medicine, Departments of Medicine and Pharmacology, Medical College of Wisconsin, Milwaukee. Search for more papers by this author and Michael E. WidlanskyMichael E. Widlansky Correspondence to: Michael E. Widlansky, MD, MPH, Medical College of Wisconsin, Hub for Collaborative Medicine, 5th Floor, 8701 W Watertown Plank Rd, Milwaukee, WI 53226. Email E-mail Address: [email protected] https://orcid.org/0000-0002-1461-9707 Division of Cardiovascular Medicine, Departments of Medicine and Pharmacology, Medical College of Wisconsin, Milwaukee. Search for more papers by this author Originally published19 Jan 2023https://doi.org/10.1161/CIRCRESAHA.122.322354Circulation Research. 2023;132:182–184This article is a commentary on the followingFlavonifractor plautii Protects Against Elevated Arterial StiffnessFootnotesFor Disclosures, see page 184.The opinions expressed in this article are not necessarily those of the editors or of the American Heart Association.Correspondence to: Michael E. Widlansky, MD, MPH, Medical College of Wisconsin, Hub for Collaborative Medicine, 5th Floor, 8701 W Watertown Plank Rd, Milwaukee, WI 53226. Email [email protected].eduReferences1. Metchnikoff E. Lactic acid as inhibiting intestinal putrefaction.Sons GPPs, ed. In: The prolongation of life. Optimistic studies. New York, London, G.P. Putnam’s Sons; 1908:161–183.Google Scholar2. Tissier H. Treatment of intestinal infections using bacterial flora of the intestine [in French].Crit Rev Soc Biol. 1906; 60:359–361.Google Scholar3. Schirmer M, Smeekens SP, Vlamakis H, Jaeger M, Oosting M, Franzosa EA, Ter Horst R, Jansen T, Jacobs L, Bonder MJ, et al. Linking the human gut microbiome to inflammatory cytokine production capacity.Cell. 2016; 167:1125–1136 e1128. doi: 10.1016/j.cell.2016.10.020CrossrefMedlineGoogle Scholar4. Brunt VE, Gioscia-Ryan RA, Casso AG, VanDongen NS, Ziemba BP, Sapinsley ZJ, Richey JJ, Zigler MC, Neilson AP, Davy KP, et al. Trimethylamine-N-oxide promotes age-related vascular oxidative stress and endothelial dysfunction in mice and healthy humans.Hypertension. 2020; 76:101–112. doi: 10.1161/hypertensionaha.120.14759LinkGoogle Scholar5. Ke Y, Li D, Zhao M, Liu C, Liu J, Zeng A, Shi X, Cheng S, Pan B, Zheng L, et al. Gut flora-dependent metabolite Trimethylamine-N-oxide accelerates endothelial cell senescence and vascular aging through oxidative stress.Free Radic Biol Med. 2018; 116:88–100. doi: 10.1016/j.freeradbiomed.2018.01.007CrossrefMedlineGoogle Scholar6. Brandsma E, Kloosterhuis NJ, Koster M, Dekker DC, Gijbels MJJ, van der Velden S, Rios-Morales M, van Faassen MJR, Loreti MG, de Bruin A, et al. A proinflammatory gut microbiota increases systemic inflammation and accelerates stherosclerosis.Circ Res. 2019; 124:94–100. doi: 10.1161/CIRCRESAHA.118.313234LinkGoogle Scholar7. Geva-Zatorsky N, Sefik E, Kua L, Pasman L, Tan TG, Ortiz-Lopez A, Yanortsang TB, Yang L, Jupp R, Mathis D, et al. Mining the human gut microbiota for immunomodulatory organisms.Cell. 2017; 168:928–943.e11. doi: 10.1016/j.cell.2017.01.022CrossrefMedlineGoogle Scholar8. Sharma R, Padwad Y. Probiotic bacteria as modulators of cellular senescence: emerging concepts and opportunities.Gut Microbes. 2020; 11:335–349. doi: 10.1080/19490976.2019.1697148CrossrefMedlineGoogle Scholar9. Luckey TD. Introduction to intestinal microecology.Am J Clin Nutr. 1972; 25:1292–1294. doi: 10.1093/ajcn/25.12.1292CrossrefMedlineGoogle Scholar10. Leviatan S, Shoer S, Rothschild D, Gorodetski M, Segal E. An expanded reference map of the human gut microbiome reveals hundreds of previously unknown species.Nat Commun. 2022; 13:3863. doi: 10.1038/s41467-022-31502-1CrossrefMedlineGoogle Scholar11. Luo SZ, Zhu S, Liu L, Cheng K, Ye B, Han Y, Fan J, Xia M. Flavonifractor plautii maintains vascular elastic network and protects against arterial stiffness.Circ Res. 2023. in pressGoogle Scholar12. Wilkinson IB, MacCallum H, Cockcroft JR, Webb DJ. Inhibition of basal nitric oxide synthesis increases aortic augmentation index and pulse wave velocity in vivo.Br J Clin Pharmacol. 2002; 53:189–192. doi: 10.1046/j.1365-2125.2002.1528adoc.xCrossrefMedlineGoogle Scholar13. Berger FK, Schwab N, Glanemann M, Bohle RM, Gartner B, Groesdonk HV. Flavonifractor (Eubacterium) plautii bloodstream infection following acute cholecystitis.IDCases. 2018; 14:e00461. doi: 10.1016/j.idcr.2018.e00461CrossrefMedlineGoogle Scholar eLetters(0)eLetters should relate to an article recently published in the journal and are not a forum for providing unpublished data. Comments are reviewed for appropriate use of tone and language. Comments are not peer-reviewed. Acceptable comments are posted to the journal website only. Comments are not published in an issue and are not indexed in PubMed. Comments should be no longer than 500 words and will only be posted online. References are limited to 10. Authors of the article cited in the comment will be invited to reply, as appropriate.Comments and feedback on AHA/ASA Scientific Statements and Guidelines should be directed to the AHA/ASA Manuscript Oversight Committee via its Correspondence page.Sign In to Submit a Response to This Article Previous Back to top Next FiguresReferencesRelatedDetailsRelated articlesFlavonifractor plautii Protects Against Elevated Arterial StiffnessShiyun Luo, et al. Circulation Research. 2023;132:167-181 January 20, 2023Vol 132, Issue 2 Advertisement Article InformationMetrics © 2023 American Heart Association, Inc.https://doi.org/10.1161/CIRCRESAHA.122.322354PMID: 36656969 Originally publishedJanuary 19, 2023 PDF download Advertisement" @default.
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