Matches in SemOpenAlex for { <https://semopenalex.org/work/W4317498051> ?p ?o ?g. }
- W4317498051 endingPage "118" @default.
- W4317498051 startingPage "89" @default.
- W4317498051 abstract "Inhibition of mTORC1 (mechanistic Target Of Rapamycin Complex 1) signaling promotes health and longevity in diverse model organisms. Over the past decade, excitement has built over the possibility that treatment with the mTORC1 inhibitor rapamycin can be utilized to treat or prevent age-related diseases in humans. However, concerns over the side effects of rapamycin on immunity and metabolism have precluded its routine use as a geroprotective therapy. Here, we discuss the evidence that these negative side effects of rapamycin are largely mediated by off-target inhibition of a second mTOR Complex (mTORC2). Further, we discuss how intermittent treatment with rapamycin, specific dietary regimens, and new molecules may provide routes to the safer and more selective inhibition of mTORC1. We conclude that the time is ripe for developing therapies based on the safe and selective inhibition of mTORC1 for the treatment or prevention of diseases of aging." @default.
- W4317498051 created "2023-01-20" @default.
- W4317498051 creator A5027295664 @default.
- W4317498051 date "2023-01-01" @default.
- W4317498051 modified "2023-09-25" @default.
- W4317498051 title "Rapamycin and rapalogs" @default.
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