Matches in SemOpenAlex for { <https://semopenalex.org/work/W4317503060> ?p ?o ?g. }
- W4317503060 abstract "Ubiquitin-fold modifier 1 (UFM1) is a ubiquitin-like molecule (UBL) discovered almost two decades ago, but our knowledge about the cellular and molecular mechanisms of this novel protein post-translational modification is still very fragmentary. In this review, we first summarize the core enzymes and factors involved in the UFMylation cascade, which, similar to ubiquitin, is consecutively catalyzed by UFM1-activating enzyme 5 (UBA5), UFM1-conjugating enzyme 1 (UFC1) and UFM1-specific ligase 1 (UFL1). Inspired by the substantial implications of UFM1 machinery in the secretory pathway, we next concentrate on the puzzling role of UFMylation in maintaining ER protein homeostasis, intending to illustrate the underlying mechanisms and future perspectives. At last, given a robust ER network is a hallmark of healthy endocrine secretory cells, we emphasize the function of UFM1 modification in physiology and pathology in the context of endocrine glands pancreas and female ovaries, aiming to provide precise insight into other internal glands of the endocrine system." @default.
- W4317503060 created "2023-01-20" @default.
- W4317503060 creator A5008185944 @default.
- W4317503060 creator A5019073332 @default.
- W4317503060 creator A5025502521 @default.
- W4317503060 creator A5076699095 @default.
- W4317503060 date "2023-01-19" @default.
- W4317503060 modified "2023-10-14" @default.
- W4317503060 title "Emerging role of UFMylation in secretory cells involved in the endocrine system by maintaining ER proteostasis" @default.
- W4317503060 cites W1523693806 @default.
- W4317503060 cites W1669458375 @default.
- W4317503060 cites W1965843055 @default.
- W4317503060 cites W1966159041 @default.
- W4317503060 cites W1968271902 @default.
- W4317503060 cites W1971945811 @default.
- W4317503060 cites W1977880312 @default.
- W4317503060 cites W1979408355 @default.
- W4317503060 cites W1981515291 @default.
- W4317503060 cites W1982844430 @default.
- W4317503060 cites W1983374699 @default.
- W4317503060 cites W1986737010 @default.
- W4317503060 cites W1990035740 @default.
- W4317503060 cites W1990588070 @default.
- W4317503060 cites W1991469184 @default.
- W4317503060 cites W1993908556 @default.
- W4317503060 cites W1994823455 @default.
- W4317503060 cites W2002439304 @default.
- W4317503060 cites W2005729589 @default.
- W4317503060 cites W2006058363 @default.
- W4317503060 cites W2015250025 @default.
- W4317503060 cites W2019263782 @default.
- W4317503060 cites W2021152920 @default.
- W4317503060 cites W2025518316 @default.
- W4317503060 cites W2029751037 @default.
- W4317503060 cites W2029969565 @default.
- W4317503060 cites W2029988348 @default.
- W4317503060 cites W2032053493 @default.
- W4317503060 cites W2033839927 @default.
- W4317503060 cites W2038626045 @default.
- W4317503060 cites W2040523398 @default.
- W4317503060 cites W2046880458 @default.
- W4317503060 cites W2057453807 @default.
- W4317503060 cites W2061154016 @default.
- W4317503060 cites W2067038570 @default.
- W4317503060 cites W2075075485 @default.
- W4317503060 cites W2080972425 @default.
- W4317503060 cites W2093284095 @default.
- W4317503060 cites W2097681320 @default.
- W4317503060 cites W2101362991 @default.
- W4317503060 cites W2115205812 @default.
- W4317503060 cites W2127848114 @default.
- W4317503060 cites W2127906377 @default.
- W4317503060 cites W2133077402 @default.
- W4317503060 cites W2147917253 @default.
- W4317503060 cites W2157926318 @default.
- W4317503060 cites W2163323666 @default.
- W4317503060 cites W2163725144 @default.
- W4317503060 cites W2182395638 @default.
- W4317503060 cites W2192080449 @default.
- W4317503060 cites W2325820673 @default.
- W4317503060 cites W2398321173 @default.
- W4317503060 cites W2403007879 @default.
- W4317503060 cites W2419598250 @default.
- W4317503060 cites W2510747145 @default.
- W4317503060 cites W2531272661 @default.
- W4317503060 cites W2575764651 @default.
- W4317503060 cites W2577458368 @default.
- W4317503060 cites W2582858424 @default.
- W4317503060 cites W2590813565 @default.
- W4317503060 cites W2617253519 @default.
- W4317503060 cites W2729448110 @default.
- W4317503060 cites W2732516376 @default.
- W4317503060 cites W2734684852 @default.
- W4317503060 cites W2766900039 @default.
- W4317503060 cites W2767179042 @default.
- W4317503060 cites W2800971173 @default.
- W4317503060 cites W2884034668 @default.
- W4317503060 cites W2885875075 @default.
- W4317503060 cites W2904223696 @default.
- W4317503060 cites W2909326124 @default.
- W4317503060 cites W2909869524 @default.
- W4317503060 cites W2912177893 @default.
- W4317503060 cites W2916517216 @default.
- W4317503060 cites W2918631811 @default.
- W4317503060 cites W2921490676 @default.
- W4317503060 cites W2955039280 @default.
- W4317503060 cites W2979414255 @default.
- W4317503060 cites W2980453182 @default.
- W4317503060 cites W2983831270 @default.
- W4317503060 cites W3005077697 @default.
- W4317503060 cites W3006678040 @default.
- W4317503060 cites W3010852509 @default.
- W4317503060 cites W3011086273 @default.
- W4317503060 cites W3030834164 @default.
- W4317503060 cites W3049399239 @default.
- W4317503060 cites W3080457712 @default.
- W4317503060 cites W3082406428 @default.
- W4317503060 cites W3088118726 @default.
- W4317503060 cites W3090484466 @default.
- W4317503060 cites W3102647357 @default.