Matches in SemOpenAlex for { <https://semopenalex.org/work/W4317503091> ?p ?o ?g. }
- W4317503091 endingPage "374" @default.
- W4317503091 startingPage "374" @default.
- W4317503091 abstract "Glioblastoma (GB) is the most prevalent primary brain cancer and the most aggressive form of glioma because of its poor prognosis and high recurrence. To confirm the importance of epigenetics in glioma, we explored The Cancer Gene Atlas (TCGA) database and we found that several histone/DNA modifications and chromatin remodeling factors were affected at transcriptional and genetic levels in GB compared to lower-grade gliomas. We associated these alterations in our own cohort of study with a significant reduction in the bulk levels of acetylated lysines 9 and 14 of histone H3 in high-grade compared to low-grade tumors. Within GB, we performed an RNA-seq analysis between samples exhibiting the lowest and highest levels of acetylated H3 in the cohort; these results are in general concordance with the transcriptional changes obtained after histone deacetylase (HDAC) inhibition of GB-derived cultures that affected relevant genes in glioma biology and treatment (e.g., A2ML1, CD83, SLC17A7, TNFSF18). Overall, we identified a transcriptional signature linked to histone acetylation that was potentially associated with good prognosis, i.e., high overall survival and low rate of somatic mutations in epigenetically related genes in GB. Our study identifies lysine acetylation as a key defective histone modification in adult high-grade glioma, and offers novel insights regarding the use of HDAC inhibitors in therapy." @default.
- W4317503091 created "2023-01-20" @default.
- W4317503091 creator A5006000641 @default.
- W4317503091 creator A5035466041 @default.
- W4317503091 creator A5063928512 @default.
- W4317503091 creator A5065717529 @default.
- W4317503091 creator A5068186871 @default.
- W4317503091 creator A5078152946 @default.
- W4317503091 creator A5089199190 @default.
- W4317503091 date "2023-01-19" @default.
- W4317503091 modified "2023-10-14" @default.
- W4317503091 title "Defining a Correlative Transcriptional Signature Associated with Bulk Histone H3 Acetylation Levels in Adult Glioblastomas" @default.
- W4317503091 cites W1935102817 @default.
- W4317503091 cites W1970597577 @default.
- W4317503091 cites W1987180785 @default.
- W4317503091 cites W1988756388 @default.
- W4317503091 cites W1993967951 @default.
- W4317503091 cites W1995105508 @default.
- W4317503091 cites W1999260149 @default.
- W4317503091 cites W2035021866 @default.
- W4317503091 cites W2039452421 @default.
- W4317503091 cites W2048575097 @default.
- W4317503091 cites W2052624043 @default.
- W4317503091 cites W2053406012 @default.
- W4317503091 cites W2054507046 @default.
- W4317503091 cites W2063346847 @default.
- W4317503091 cites W2071167433 @default.
- W4317503091 cites W2081758137 @default.
- W4317503091 cites W2090574965 @default.
- W4317503091 cites W2096287682 @default.
- W4317503091 cites W2096670842 @default.
- W4317503091 cites W2097753794 @default.
- W4317503091 cites W2099343472 @default.
- W4317503091 cites W2101870168 @default.
- W4317503091 cites W2102428449 @default.
- W4317503091 cites W2106204137 @default.
- W4317503091 cites W2116743866 @default.
- W4317503091 cites W2131941125 @default.
- W4317503091 cites W2134847995 @default.
- W4317503091 cites W2135891497 @default.
- W4317503091 cites W2146512944 @default.
- W4317503091 cites W2159579377 @default.
- W4317503091 cites W2162794030 @default.
- W4317503091 cites W2166959941 @default.
- W4317503091 cites W2179638825 @default.
- W4317503091 cites W2295872600 @default.
- W4317503091 cites W2348404910 @default.
- W4317503091 cites W2460281529 @default.
- W4317503091 cites W2602832336 @default.
- W4317503091 cites W2603517011 @default.
- W4317503091 cites W2792979573 @default.
- W4317503091 cites W2801311330 @default.
- W4317503091 cites W2808522237 @default.
- W4317503091 cites W2938768180 @default.
- W4317503091 cites W2981090346 @default.
- W4317503091 cites W3034155600 @default.
- W4317503091 cites W3043093285 @default.
- W4317503091 cites W3092551341 @default.
- W4317503091 cites W3108356933 @default.
- W4317503091 cites W3108830602 @default.
- W4317503091 cites W3132701351 @default.
- W4317503091 cites W3138638334 @default.
- W4317503091 cites W3170691288 @default.
- W4317503091 cites W3174246647 @default.
- W4317503091 cites W3185657284 @default.
- W4317503091 cites W3191861431 @default.
- W4317503091 cites W3192683516 @default.
- W4317503091 cites W3204186072 @default.
- W4317503091 cites W3205890783 @default.
- W4317503091 cites W4214773561 @default.
- W4317503091 cites W4220697890 @default.
- W4317503091 cites W4220846698 @default.
- W4317503091 cites W4225984600 @default.
- W4317503091 cites W4281260915 @default.
- W4317503091 doi "https://doi.org/10.3390/cells12030374" @default.
- W4317503091 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36766715" @default.
- W4317503091 hasPublicationYear "2023" @default.
- W4317503091 type Work @default.
- W4317503091 citedByCount "1" @default.
- W4317503091 countsByYear W43175030912023 @default.
- W4317503091 crossrefType "journal-article" @default.
- W4317503091 hasAuthorship W4317503091A5006000641 @default.
- W4317503091 hasAuthorship W4317503091A5035466041 @default.
- W4317503091 hasAuthorship W4317503091A5063928512 @default.
- W4317503091 hasAuthorship W4317503091A5065717529 @default.
- W4317503091 hasAuthorship W4317503091A5068186871 @default.
- W4317503091 hasAuthorship W4317503091A5078152946 @default.
- W4317503091 hasAuthorship W4317503091A5089199190 @default.
- W4317503091 hasBestOaLocation W43175030911 @default.
- W4317503091 hasConcept C104317684 @default.
- W4317503091 hasConcept C114691636 @default.
- W4317503091 hasConcept C119157956 @default.
- W4317503091 hasConcept C150425827 @default.
- W4317503091 hasConcept C2776745794 @default.
- W4317503091 hasConcept C2778227246 @default.
- W4317503091 hasConcept C2778305200 @default.
- W4317503091 hasConcept C41091548 @default.
- W4317503091 hasConcept C502942594 @default.