FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4317506875> ?p ?o ?g. }

• W4317506875 endingPage "1096" @default.
• W4317506875 startingPage "1089" @default.
• W4317506875 abstract "Abstract Objective To explore whether deintensification of adjuvant therapy reduces ototoxicity among patients with human papillomavirus (HPV)‐related oropharyngeal squamous cell carcinoma (OPSCC). Study Design Retrospective cohort study. Setting Single academic center. Methods The ototoxicity rate among adult patients with HPV‐related OPSCC enrolled in the Minimalist Trial (MINT), a prospective phase 2 trial of surgery followed by risk‐adjusted deintensified adjuvant therapy (42 Gy radiation given alone or with a single 100 mg/m 2 dose of cisplatin), was compared to that among a historical cohort treated with standard adjuvant therapy (60‐66 Gy radiation with up to three 100 mg/m 2 doses of cisplatin). Ototoxicity was defined as Common Terminology Criteria for Adverse Events v5.0 ≥ Grade 2. Mixed model analysis was performed to investigate the association between deintensified adjuvant therapy and treatment‐related hearing loss. Results A total of 29 patients (58 ears) were analyzed in the MINT cohort, and 27 patients (54 ears) in the historical cohort. The ototoxicity rate was 5% (n = 3/58 ears) in the MINT cohort and 46% (n = 25/54 ears) in the historical cohort (difference, 41%; 95% confidence interval [CI] = 27%‐56%). Patients in the MINT cohort demonstrated a 95% decrease in risk of ototoxicity compared to those in the historical cohort (adjusted odds ratio: 0.05, 95% CI = 0.01‐0.31). Differences in estimated marginal mean threshold shifts were statistically and clinically significant at frequencies ≥ 3 kHz. Conclusion The deintensified adjuvant therapy given in MINT led to less ototoxicity than standard adjuvant therapy among patients with HPV‐related OPSCC." @default.
• W4317506875 created "2023-01-20" @default.
• W4317506875 creator A5005956102 @default.
• W4317506875 creator A5006851320 @default.
• W4317506875 creator A5014241636 @default.
• W4317506875 creator A5024663065 @default.
• W4317506875 creator A5027605173 @default.
• W4317506875 creator A5028104092 @default.
• W4317506875 creator A5046944161 @default.
• W4317506875 creator A5064319129 @default.
• W4317506875 creator A5070756569 @default.
• W4317506875 creator A5072448404 @default.
• W4317506875 creator A5082167220 @default.
• W4317506875 date "2023-01-19" @default.
• W4317506875 modified "2023-10-02" @default.
• W4317506875 title "Hearing Outcomes in a Deintensification Trial of Adjuvant Therapy for HPV‐Related Oropharyngeal Squamous Cell Carcinoma" @default.
• W4317506875 cites W1571358543 @default.
• W4317506875 cites W1924127536 @default.
• W4317506875 cites W1996440955 @default.
• W4317506875 cites W2017673775 @default.
• W4317506875 cites W2029328961 @default.
• W4317506875 cites W2052592452 @default.
• W4317506875 cites W2070669025 @default.
• W4317506875 cites W2089244804 @default.
• W4317506875 cites W2110664940 @default.
• W4317506875 cites W2111442242 @default.
• W4317506875 cites W2513060759 @default.
• W4317506875 cites W2564530713 @default.
• W4317506875 cites W2737968823 @default.
• W4317506875 cites W2768737575 @default.
• W4317506875 cites W2889843738 @default.
• W4317506875 cites W2898016980 @default.
• W4317506875 cites W2901385432 @default.
• W4317506875 cites W2906068694 @default.
• W4317506875 cites W2941607499 @default.
• W4317506875 cites W2990308328 @default.
• W4317506875 cites W3005918986 @default.
• W4317506875 cites W3111258920 @default.
• W4317506875 cites W3119648282 @default.
• W4317506875 cites W3186296540 @default.
• W4317506875 cites W3212253346 @default.
• W4317506875 cites W4220921075 @default.
• W4317506875 cites W4233062233 @default.
• W4317506875 doi "https://doi.org/10.1002/ohn.182" @default.
• W4317506875 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36939390" @default.
• W4317506875 hasPublicationYear "2023" @default.
• W4317506875 type Work @default.
• W4317506875 citedByCount "0" @default.
• W4317506875 crossrefType "journal-article" @default.
• W4317506875 hasAuthorship W4317506875A5005956102 @default.
• W4317506875 hasAuthorship W4317506875A5006851320 @default.
• W4317506875 hasAuthorship W4317506875A5014241636 @default.
• W4317506875 hasAuthorship W4317506875A5024663065 @default.
• W4317506875 hasAuthorship W4317506875A5027605173 @default.
• W4317506875 hasAuthorship W4317506875A5028104092 @default.
• W4317506875 hasAuthorship W4317506875A5046944161 @default.
• W4317506875 hasAuthorship W4317506875A5064319129 @default.
• W4317506875 hasAuthorship W4317506875A5070756569 @default.
• W4317506875 hasAuthorship W4317506875A5072448404 @default.
• W4317506875 hasAuthorship W4317506875A5082167220 @default.
• W4317506875 hasConcept C121608353 @default.
• W4317506875 hasConcept C126322002 @default.
• W4317506875 hasConcept C141071460 @default.
• W4317506875 hasConcept C143998085 @default.
• W4317506875 hasConcept C156957248 @default.
• W4317506875 hasConcept C167135981 @default.
• W4317506875 hasConcept C197934379 @default.
• W4317506875 hasConcept C201903717 @default.
• W4317506875 hasConcept C2776694085 @default.
• W4317506875 hasConcept C2777793932 @default.
• W4317506875 hasConcept C2777982462 @default.
• W4317506875 hasConcept C2778239845 @default.
• W4317506875 hasConcept C2778534666 @default.
• W4317506875 hasConcept C44249647 @default.
• W4317506875 hasConcept C509974204 @default.
• W4317506875 hasConcept C71924100 @default.
• W4317506875 hasConcept C72563966 @default.
• W4317506875 hasConceptScore W4317506875C121608353 @default.
• W4317506875 hasConceptScore W4317506875C126322002 @default.
• W4317506875 hasConceptScore W4317506875C141071460 @default.
• W4317506875 hasConceptScore W4317506875C143998085 @default.
• W4317506875 hasConceptScore W4317506875C156957248 @default.
• W4317506875 hasConceptScore W4317506875C167135981 @default.
• W4317506875 hasConceptScore W4317506875C197934379 @default.
• W4317506875 hasConceptScore W4317506875C201903717 @default.
• W4317506875 hasConceptScore W4317506875C2776694085 @default.
• W4317506875 hasConceptScore W4317506875C2777793932 @default.
• W4317506875 hasConceptScore W4317506875C2777982462 @default.
• W4317506875 hasConceptScore W4317506875C2778239845 @default.
• W4317506875 hasConceptScore W4317506875C2778534666 @default.
• W4317506875 hasConceptScore W4317506875C44249647 @default.
• W4317506875 hasConceptScore W4317506875C509974204 @default.
• W4317506875 hasConceptScore W4317506875C71924100 @default.
• W4317506875 hasConceptScore W4317506875C72563966 @default.
• W4317506875 hasIssue "5" @default.
• W4317506875 hasLocation W43175068751 @default.
• W4317506875 hasLocation W43175068752 @default.
• W4317506875 hasOpenAccess W4317506875 @default.

• next