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- W4317508619 endingPage "162" @default.
- W4317508619 startingPage "162" @default.
- W4317508619 abstract "Endogenous retroviruses (ERVs), or LTR retrotransposons, are a class of transposable elements that are highly represented in mammalian genomes. Human ERVs (HERVs) make up roughly 8.3% of the genome and over the course of evolution, HERV elements underwent positive selection and accrued mutations that rendered them non-infectious; thereby, the genome could co-opt them into constructive roles with important biological functions. In the past two decades, with the help of advances in sequencing technology, ERVs are increasingly considered to be important components of the innate immune response. While typically silenced, expression of HERVs can be induced in response to traumatic, toxic, or infection-related stress, leading to a buildup of viral transcripts and under certain circumstances, proteins, including functionally active reverse transcriptase and viral envelopes. The biological activity of HERVs in the context of the innate immune response can be based on the functional effect of four major viral components: (1) HERV LTRs, (2) HERV-derived RNAs, (3) HERV-derived RNA:DNA duplexes and cDNA, and (4) HERV-derived proteins and ribonucleoprotein complexes. In this review, we will discuss the implications of HERVs in all four contexts in relation to innate immunity and their association with various pathological disease states." @default.
- W4317508619 created "2023-01-20" @default.
- W4317508619 creator A5015673472 @default.
- W4317508619 creator A5066916338 @default.
- W4317508619 date "2023-01-19" @default.
- W4317508619 modified "2023-10-09" @default.
- W4317508619 title "Endogenous Retroviruses as Modulators of Innate Immunity" @default.
- W4317508619 cites W1482190741 @default.
- W4317508619 cites W1491910236 @default.
- W4317508619 cites W1543402161 @default.
- W4317508619 cites W1595314594 @default.
- W4317508619 cites W1784857457 @default.
- W4317508619 cites W1892383201 @default.
- W4317508619 cites W1905278501 @default.
- W4317508619 cites W1951507118 @default.
- W4317508619 cites W1953890763 @default.
- W4317508619 cites W1966104640 @default.
- W4317508619 cites W1969072247 @default.
- W4317508619 cites W1977365752 @default.
- W4317508619 cites W1982718713 @default.
- W4317508619 cites W1984004239 @default.
- W4317508619 cites W1985581386 @default.
- W4317508619 cites W1994440387 @default.
- W4317508619 cites W2009858080 @default.
- W4317508619 cites W2017749542 @default.
- W4317508619 cites W2018262098 @default.
- W4317508619 cites W2018513930 @default.
- W4317508619 cites W2022182007 @default.
- W4317508619 cites W2022936129 @default.
- W4317508619 cites W2023142724 @default.
- W4317508619 cites W2023455251 @default.
- W4317508619 cites W2026880497 @default.
- W4317508619 cites W2027835215 @default.
- W4317508619 cites W2028575270 @default.
- W4317508619 cites W2028917545 @default.
- W4317508619 cites W2032070270 @default.
- W4317508619 cites W2032966566 @default.
- W4317508619 cites W2040891039 @default.
- W4317508619 cites W2042086471 @default.
- W4317508619 cites W2042816890 @default.
- W4317508619 cites W2042992404 @default.
- W4317508619 cites W2044258993 @default.
- W4317508619 cites W2045302592 @default.
- W4317508619 cites W2049989206 @default.
- W4317508619 cites W2054446204 @default.
- W4317508619 cites W2057660488 @default.
- W4317508619 cites W2057931534 @default.
- W4317508619 cites W2059919630 @default.
- W4317508619 cites W2060915836 @default.
- W4317508619 cites W2061715434 @default.
- W4317508619 cites W2061840698 @default.
- W4317508619 cites W2061867473 @default.
- W4317508619 cites W2063310200 @default.
- W4317508619 cites W2075697713 @default.
- W4317508619 cites W2084590775 @default.
- W4317508619 cites W2090546484 @default.
- W4317508619 cites W2092413767 @default.
- W4317508619 cites W2101766820 @default.
- W4317508619 cites W2103327619 @default.
- W4317508619 cites W2108794690 @default.
- W4317508619 cites W2109491705 @default.
- W4317508619 cites W2109715808 @default.
- W4317508619 cites W2111801210 @default.
- W4317508619 cites W2114546997 @default.
- W4317508619 cites W2116710635 @default.
- W4317508619 cites W2117171675 @default.
- W4317508619 cites W2118092662 @default.
- W4317508619 cites W2119655850 @default.
- W4317508619 cites W2121264550 @default.
- W4317508619 cites W2123930160 @default.
- W4317508619 cites W2125040797 @default.
- W4317508619 cites W2129649737 @default.
- W4317508619 cites W2132001965 @default.
- W4317508619 cites W2133003848 @default.
- W4317508619 cites W2136329789 @default.
- W4317508619 cites W2138677670 @default.
- W4317508619 cites W2138753535 @default.
- W4317508619 cites W2141488802 @default.
- W4317508619 cites W2145578294 @default.
- W4317508619 cites W2146671969 @default.
- W4317508619 cites W2148214390 @default.
- W4317508619 cites W2149613931 @default.
- W4317508619 cites W2152656267 @default.
- W4317508619 cites W2153342952 @default.
- W4317508619 cites W2157571263 @default.
- W4317508619 cites W2161355626 @default.
- W4317508619 cites W2161376188 @default.
- W4317508619 cites W2162877758 @default.
- W4317508619 cites W2162895870 @default.
- W4317508619 cites W2165549831 @default.
- W4317508619 cites W2167438636 @default.
- W4317508619 cites W2168909179 @default.
- W4317508619 cites W2171727559 @default.
- W4317508619 cites W2290849670 @default.
- W4317508619 cites W2296543788 @default.
- W4317508619 cites W2305132501 @default.
- W4317508619 cites W2479703093 @default.
- W4317508619 cites W2544859297 @default.