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- W4317508873 endingPage "1930" @default.
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- W4317508873 abstract "The COVID-19 pandemic has required extensive research on the new coronavirus SARS-CoV-2 and the creation of new highly effective vaccines. The presence of T-cells in the body that respond to virus antigens suggests adequate antiviral immunity. We investigated T-cell immunity in individuals who recovered from mild and moderate COVID-19 and in individuals vaccinated with the Gam-COVID-Vac combined vector vaccine. The ELISPOT method was used to determine the number of T-cells responding with IFN-γ synthesis to stimulation by peptides containing epitopes of the S-protein or N-, M-, ORF3, and ORF7 proteins, using peripheral blood mononuclear cells (PBMCs). At the same time, the multiplex method was used to determine the accumulation of IFN-γ and other cytokines in the culture medium. According to the data obtained, the proportion of positive conclusions about the T-cell immune response to SARS-CoV-2 antigens in control, recovered, and vaccinated individuals was 12%, 70%, and 52%, respectively. At the same time, more than half of the vaccinated individuals with a T-cell response were sensitized to the antigens of N-, M-, ORF3, and ORF7 proteins not produced by Gam-COVID-Vac, indicating a high likelihood of asymptomatic SARS-CoV-2 infection. Increased IFN-γ release by single sensitized T-cells in response to specific stimulation in recovered and vaccinated individuals did not result in the accumulation of this and other cytokines in the culture medium. These findings suggest a balance between cytokine production and utilization by immunocompetent cells as a prerequisite for providing a controlled cytokine signal and avoiding a “cytokine storm”." @default.
- W4317508873 created "2023-01-20" @default.
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- W4317508873 date "2023-01-18" @default.
- W4317508873 modified "2023-09-27" @default.
- W4317508873 title "T-Cell Immunity in COVID-19-Recovered Individuals and Individuals Vaccinated with the Combined Vector Vaccine Gam-COVID-Vac" @default.
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- W4317508873 cites W3164223157 @default.
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- W4317508873 cites W3176668337 @default.
- W4317508873 cites W3186042928 @default.
- W4317508873 cites W3190228787 @default.
- W4317508873 cites W3196516725 @default.
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- W4317508873 cites W4213072876 @default.
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- W4317508873 doi "https://doi.org/10.3390/ijms24031930" @default.
- W4317508873 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36768254" @default.
- W4317508873 hasPublicationYear "2023" @default.
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