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- W4317509934 endingPage "1919" @default.
- W4317509934 startingPage "1919" @default.
- W4317509934 abstract "The circadian clock is a regulatory system, with a periodicity of approximately 24 h, that generates rhythmic changes in many physiological processes. Increasing evidence links chronodisruption with aberrant functionality in clock gene expression, resulting in multiple diseases, including cancer. In this context, tumor cells have an altered circadian machinery compared to normal cells, which deregulates the cell cycle, repair mechanisms, energy metabolism and other processes. Melatonin is the main hormone produced by the pineal gland, whose production and secretion oscillates in accordance with the light:dark cycle. In addition, melatonin regulates the expression of clock genes, including those in cancer cells, which could play a key role in the numerous oncostatic effects of this hormone. This review aims to describe and clarify the role of clock genes in cancer, as well as the possible mechanisms of the action of melatonin through which it regulates the expression of the tumor’s circadian machinery, in order to propose future anti-neoplastic clinical treatments." @default.
- W4317509934 created "2023-01-20" @default.
- W4317509934 creator A5007383535 @default.
- W4317509934 creator A5015361452 @default.
- W4317509934 creator A5064048303 @default.
- W4317509934 creator A5072168650 @default.
- W4317509934 creator A5076629574 @default.
- W4317509934 creator A5090157656 @default.
- W4317509934 date "2023-01-18" @default.
- W4317509934 modified "2023-10-18" @default.
- W4317509934 title "Role of Melatonin in Cancer: Effect on Clock Genes" @default.
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