Matches in SemOpenAlex for { <https://semopenalex.org/work/W4317523280> ?p ?o ?g. }
- W4317523280 endingPage "240" @default.
- W4317523280 startingPage "187" @default.
- W4317523280 abstract "Heme oxygenase-1 (HO-1), an oxidative stress-response gene up-regulated by various physiological and exogenous stimuli, has cytoprotective activities. Ischemic postconditioning (Postcon) can protect an organ from ischemia-reperfusion (I/R) injury. In the present study, we investigated the potential contributions of HO-1 to Postcon-dependent protection against I/R injury in rat liver transplantation models.Adult male Sprague-Dawley rats were randomly divided into four groups: sham group with laparotomy for liver exposure; I/R group with 24-hour cold ischemia of the donor liver; Postcon group with the same treatment as the I/R group plus ischemic Postcon; and zinc protoporphyrin (ZnPP HO-1 inhibitor) + Postcon group treated the same as the Postcon cohort with donors pretreated using ZnPP 24 hours before the I/R injury. We measured liver tissue and peripheral blood samples collected at 6 hours after reperfusion and serum transaminase levels, histopathology, liver tissue malondialdehyde (MDA) content, superoxide dismutase (SOD) activity and HO-1 expression in the liver.Postcon significantly diminished the elevation of serum transaminases levels after I/R injury when compared with I/R and ZnPP+Postcon groups. Postcon treated rats showed significantly lower MDA production and higher SOD activity. HO-1 was induced in rat livers exposed to Postcon; its levels were obviously overexpressed after 6 hours in Postcon rats. Inhibiting the expression of HO-1, negated the protective effects of Postcon.Induction of HO-1 in the Postcon condition played a protective role against hepatic I/R injury and enhanced the early antioxidative activity. The protective effects of Postcon were significantly associated with greater intrahepatic HO-1 expression." @default.
- W4317523280 created "2023-01-20" @default.
- W4317523280 creator A5022963653 @default.
- W4317523280 creator A5081289232 @default.
- W4317523280 date "1990-04-01" @default.
- W4317523280 modified "2023-10-14" @default.
- W4317523280 title "Liver transplantation: A 31-year perspective part III" @default.
- W4317523280 cites W138764853 @default.
- W4317523280 cites W1500363302 @default.
- W4317523280 cites W1521342707 @default.
- W4317523280 cites W1594724806 @default.
- W4317523280 cites W1608215573 @default.
- W4317523280 cites W1613664893 @default.
- W4317523280 cites W1651695215 @default.
- W4317523280 cites W1660798880 @default.
- W4317523280 cites W1738365327 @default.
- W4317523280 cites W1795139088 @default.
- W4317523280 cites W1890293889 @default.
- W4317523280 cites W1965988561 @default.
- W4317523280 cites W1968554411 @default.
- W4317523280 cites W1969090270 @default.
- W4317523280 cites W196981708 @default.
- W4317523280 cites W1971734830 @default.
- W4317523280 cites W1974227041 @default.
- W4317523280 cites W1975994802 @default.
- W4317523280 cites W1978175203 @default.
- W4317523280 cites W1981548394 @default.
- W4317523280 cites W1982638872 @default.
- W4317523280 cites W1983231842 @default.
- W4317523280 cites W1983678584 @default.
- W4317523280 cites W1985670794 @default.
- W4317523280 cites W1986246266 @default.
- W4317523280 cites W1986563833 @default.
- W4317523280 cites W1986752644 @default.
- W4317523280 cites W1986819764 @default.
- W4317523280 cites W1987985804 @default.
- W4317523280 cites W1988216509 @default.
- W4317523280 cites W1989363801 @default.
- W4317523280 cites W1993119677 @default.
- W4317523280 cites W1994519312 @default.
- W4317523280 cites W1994632200 @default.
- W4317523280 cites W2000706457 @default.
- W4317523280 cites W2002208305 @default.
- W4317523280 cites W2003595552 @default.
- W4317523280 cites W2003648076 @default.
- W4317523280 cites W2004798317 @default.
- W4317523280 cites W2006548217 @default.
- W4317523280 cites W2007169413 @default.
- W4317523280 cites W2009844134 @default.
- W4317523280 cites W2011292580 @default.
- W4317523280 cites W2013971858 @default.
- W4317523280 cites W2015659054 @default.
- W4317523280 cites W2015668249 @default.
- W4317523280 cites W2020897440 @default.
- W4317523280 cites W2024428413 @default.
- W4317523280 cites W2025123467 @default.
- W4317523280 cites W2026326314 @default.
- W4317523280 cites W2028174175 @default.
- W4317523280 cites W2028250846 @default.
- W4317523280 cites W2028482709 @default.
- W4317523280 cites W2029844863 @default.
- W4317523280 cites W2033250565 @default.
- W4317523280 cites W2033263018 @default.
- W4317523280 cites W2036432857 @default.
- W4317523280 cites W2038341270 @default.
- W4317523280 cites W2038360824 @default.
- W4317523280 cites W2043241732 @default.
- W4317523280 cites W2043242009 @default.
- W4317523280 cites W2044042406 @default.
- W4317523280 cites W2045309234 @default.
- W4317523280 cites W2046466271 @default.
- W4317523280 cites W2046776956 @default.
- W4317523280 cites W2047711152 @default.
- W4317523280 cites W2048020052 @default.
- W4317523280 cites W2048070434 @default.
- W4317523280 cites W2048400898 @default.
- W4317523280 cites W2051770321 @default.
- W4317523280 cites W2053995238 @default.
- W4317523280 cites W2056464337 @default.
- W4317523280 cites W2060469405 @default.
- W4317523280 cites W2061647139 @default.
- W4317523280 cites W2062228437 @default.
- W4317523280 cites W2063005009 @default.
- W4317523280 cites W2066124462 @default.
- W4317523280 cites W2066507221 @default.
- W4317523280 cites W2066686850 @default.
- W4317523280 cites W2066962401 @default.
- W4317523280 cites W2067869320 @default.
- W4317523280 cites W2069318657 @default.
- W4317523280 cites W2073024657 @default.
- W4317523280 cites W2080113262 @default.
- W4317523280 cites W2082782935 @default.
- W4317523280 cites W2084263035 @default.
- W4317523280 cites W2085668981 @default.
- W4317523280 cites W2089658195 @default.
- W4317523280 cites W2093834364 @default.
- W4317523280 cites W20939962 @default.
- W4317523280 cites W2095497010 @default.