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• W4317539132 abstract "Dysphagia is a major cause of stroke infection and death, and identification of structural and functional brain area changes associated with post-stroke dysphagia (PSD) can help in early screening and clinical intervention. Studies on PSD have reported numerous structural lesions and functional abnormalities in brain regions, and a systematic review is lacking. We aimed to integrate several neuroimaging studies to summarize the empirical evidence of neurological changes leading to PSD.We conducted a systematic review of studies that used structural neuroimaging and functional neuroimaging approaches to explore structural and functional brain regions associated with swallowing after stroke, with additional evidence using a live activation likelihood estimation (ALE) approach.A total of 35 studies were included, including 20 studies with structural neuroimaging analysis, 14 studies with functional neuroimaging analysis and one study reporting results for both. The overall results suggest that structural lesions and functional abnormalities in the sensorimotor cortex, insula, cerebellum, cingulate gyrus, thalamus, basal ganglia, and associated white matter connections in individuals with stroke may contribute to dysphagia, and the ALE analysis provides additional evidence for structural lesions in the right lentiform nucleus and right thalamus and functional abnormalities in the left thalamus.Our findings suggest that PSD is associated with neurological changes in brain regions such as sensorimotor cortex, insula, cerebellum, cingulate gyrus, thalamus, basal ganglia, and associated white matter connections. Adequate understanding of the mechanisms of neural changes in the post-stroke swallowing network may assist in clinical diagnosis and provide ideas for the development of new interventions in clinical practice." @default.
• W4317539132 created "2023-01-20" @default.
• W4317539132 creator A5005322009 @default.
• W4317539132 creator A5048145081 @default.
• W4317539132 creator A5070235634 @default.
• W4317539132 creator A5077819234 @default.
• W4317539132 date "2023-01-20" @default.
• W4317539132 modified "2023-10-14" @default.
• W4317539132 title "Neural basis of dysphagia in stroke: A systematic review and meta-analysis" @default.
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• W4317539132 doi "https://doi.org/10.3389/fnhum.2023.1077234" @default.
• W4317539132 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36742358" @default.

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