Matches in SemOpenAlex for { <https://semopenalex.org/work/W4317542844> ?p ?o ?g. }
- W4317542844 abstract "Abstract Laboratory surveillance of Streptococcus pneumoniae serotypes is crucial for the successful implementation of vaccines to prevent invasive pneumococcal diseases. The reference method of serotyping is the Quellung reaction, which is labor-intensive and expensive. In the last few years, the introduction of MALDI-TOF MS into the microbiology laboratory has been revolutionary. In brief, this new technology compares protein profiles by generating spectra based on the m/z ratio. We evaluated the performance of MALDI-TOF MS for typing serotypes of S. pneumoniae isolates included in the PCV13 vaccine using a machine learning approach. We challenged our classification algorithms in “real time” with a total of new 100 isolates of S. pneumoniae from Argentinian nationwide surveillance. Our best approach could correctly identify the isolates with a sensitivity of 58.33% ([95%IC 40.7–71.7]); specificity of 81.48% ([95%IC 53.6–79.7]); accuracy of 63.0% ([95%IC 61.9–93.7]); PPV of 80.77% ([95%IC 64.5–90.6]) and NPV of 59.46% ([95%IC 48.9–69.2]). In this work, it was possible to demonstrate that the combination of MALDI-TOF mass spectrometry and multivariate analysis allows the development of new strategies for the identification and characterization of Spn isolates of clinical importance." @default.
- W4317542844 created "2023-01-20" @default.
- W4317542844 creator A5011941747 @default.
- W4317542844 creator A5035625255 @default.
- W4317542844 creator A5042831116 @default.
- W4317542844 creator A5045890733 @default.
- W4317542844 creator A5068004877 @default.
- W4317542844 creator A5080676097 @default.
- W4317542844 creator A5087341372 @default.
- W4317542844 date "2023-01-20" @default.
- W4317542844 modified "2023-09-27" @default.
- W4317542844 title "À la carte, Streptococcus pneumoniae capsular typing: using MALDI-TOF mass spectrometry and machine-learning algorithms as complementary tools for the determination of PCV13 serotypes and the most prevalent NON PCV13 serotypes according to Argentina’s epidemiology" @default.
- W4317542844 cites W1142453714 @default.
- W4317542844 cites W1565128354 @default.
- W4317542844 cites W1867952113 @default.
- W4317542844 cites W1869307899 @default.
- W4317542844 cites W1895102180 @default.
- W4317542844 cites W1963985157 @default.
- W4317542844 cites W1964697646 @default.
- W4317542844 cites W2006068181 @default.
- W4317542844 cites W2008673943 @default.
- W4317542844 cites W2010514663 @default.
- W4317542844 cites W2026560502 @default.
- W4317542844 cites W2050018214 @default.
- W4317542844 cites W2053889461 @default.
- W4317542844 cites W2062567419 @default.
- W4317542844 cites W2064618548 @default.
- W4317542844 cites W2070218734 @default.
- W4317542844 cites W2075145458 @default.
- W4317542844 cites W2090482417 @default.
- W4317542844 cites W2101342342 @default.
- W4317542844 cites W2105267960 @default.
- W4317542844 cites W2131970571 @default.
- W4317542844 cites W2135225892 @default.
- W4317542844 cites W2145435157 @default.
- W4317542844 cites W2149560880 @default.
- W4317542844 cites W2158296236 @default.
- W4317542844 cites W2164768742 @default.
- W4317542844 cites W2164777277 @default.
- W4317542844 cites W2174465621 @default.
- W4317542844 cites W2266618839 @default.
- W4317542844 cites W2575795480 @default.
- W4317542844 cites W2608209613 @default.
- W4317542844 cites W2899716264 @default.
- W4317542844 cites W2914376563 @default.
- W4317542844 cites W2932613184 @default.
- W4317542844 cites W2951982740 @default.
- W4317542844 cites W2995977069 @default.
- W4317542844 cites W3028254348 @default.
- W4317542844 cites W3092552393 @default.
- W4317542844 cites W3094519139 @default.
- W4317542844 cites W3117538016 @default.
- W4317542844 cites W3138566178 @default.
- W4317542844 cites W3160605001 @default.
- W4317542844 cites W3214714065 @default.
- W4317542844 doi "https://doi.org/10.21203/rs.3.rs-2483976/v1" @default.
- W4317542844 hasPublicationYear "2023" @default.
- W4317542844 type Work @default.
- W4317542844 citedByCount "0" @default.
- W4317542844 crossrefType "posted-content" @default.
- W4317542844 hasAuthorship W4317542844A5011941747 @default.
- W4317542844 hasAuthorship W4317542844A5035625255 @default.
- W4317542844 hasAuthorship W4317542844A5042831116 @default.
- W4317542844 hasAuthorship W4317542844A5045890733 @default.
- W4317542844 hasAuthorship W4317542844A5068004877 @default.
- W4317542844 hasAuthorship W4317542844A5080676097 @default.
- W4317542844 hasAuthorship W4317542844A5087341372 @default.
- W4317542844 hasBestOaLocation W43175428441 @default.
- W4317542844 hasConcept C10389963 @default.
- W4317542844 hasConcept C11413529 @default.
- W4317542844 hasConcept C162356407 @default.
- W4317542844 hasConcept C185592680 @default.
- W4317542844 hasConcept C2781209916 @default.
- W4317542844 hasConcept C2781253189 @default.
- W4317542844 hasConcept C2992965680 @default.
- W4317542844 hasConcept C41008148 @default.
- W4317542844 hasConcept C43617362 @default.
- W4317542844 hasConcept C501593827 @default.
- W4317542844 hasConcept C71924100 @default.
- W4317542844 hasConcept C86803240 @default.
- W4317542844 hasConcept C89423630 @default.
- W4317542844 hasConceptScore W4317542844C10389963 @default.
- W4317542844 hasConceptScore W4317542844C11413529 @default.
- W4317542844 hasConceptScore W4317542844C162356407 @default.
- W4317542844 hasConceptScore W4317542844C185592680 @default.
- W4317542844 hasConceptScore W4317542844C2781209916 @default.
- W4317542844 hasConceptScore W4317542844C2781253189 @default.
- W4317542844 hasConceptScore W4317542844C2992965680 @default.
- W4317542844 hasConceptScore W4317542844C41008148 @default.
- W4317542844 hasConceptScore W4317542844C43617362 @default.
- W4317542844 hasConceptScore W4317542844C501593827 @default.
- W4317542844 hasConceptScore W4317542844C71924100 @default.
- W4317542844 hasConceptScore W4317542844C86803240 @default.
- W4317542844 hasConceptScore W4317542844C89423630 @default.
- W4317542844 hasLocation W43175428441 @default.
- W4317542844 hasLocation W43175428442 @default.
- W4317542844 hasOpenAccess W4317542844 @default.
- W4317542844 hasPrimaryLocation W43175428441 @default.
- W4317542844 hasRelatedWork W2033031080 @default.
- W4317542844 hasRelatedWork W2079583890 @default.