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- W4317548424 abstract "A series of 1H-benzo[f]chromene moieties (4a-z) were synthesised under Ultrasonic irradiation and confirmed with spectral analyses. Derivative 4i solely possessed an X-ray single crystal. The anti-proliferative efficacy of the desired molecules has been explored against three cancer cells: MCF-7, HCT-116, and HepG-2 with the cytotoxically active derivatives screened against MCF-7/ADR and normal cells HFL-1 and WI-38. Furthermore, compounds 4b-d, 4k, 4n, 4q, and 4w, which possessed good potency against MCF-7/ADR, were tested as permeability glycoprotein (P-glycoprotein [P-gp]) expression inhibitors. The attained data confirmed that 4b-d, 4q, and 4w exhibited strong expression inhibition against the P-gp alongside its cytotoxic effect on MCF-7/ADR. The western blot results and Rho123 accumulation assays showed that compounds 4b-d, 4q, and 4w effectively inhibited the P-gp expression and efflux function. Meanwhile, 4b-d, 4q, and 4w induced apoptosis and accumulation of the treated MCF-7/ADR cells in the G1 phase and 4k and 4n in the S phase of the cell cycle." @default.
- W4317548424 created "2023-01-20" @default.
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- W4317548424 date "2023-01-20" @default.
- W4317548424 modified "2023-10-14" @default.
- W4317548424 title "Discovery of benzochromene derivatives first example with dual cytotoxic activity against the resistant cancer cell MCF-7/ADR and inhibitory effect of the <i>P</i>-glycoprotein expression levels" @default.
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- W4317548424 doi "https://doi.org/10.1080/14756366.2022.2155814" @default.
- W4317548424 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36662632" @default.
- W4317548424 hasPublicationYear "2023" @default.
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