Matches in SemOpenAlex for { <https://semopenalex.org/work/W4317548786> ?p ?o ?g. }
- W4317548786 endingPage "117177" @default.
- W4317548786 startingPage "117177" @default.
- W4317548786 abstract "A series of pyrazole-fused oleanolic acid derivatives were designed and synthesized. The modification of these analogues focused on the substituents screening on the pyrazole ring. The cytotoxicity of these compounds and their anti-inflammatory activities via inhibiting interleukin-1β (IL-1β) production were evaluated in RAW264.7 cells. Most of the derivatives showed significantly improved potency compared with oleanolic acid. Among them, compound 7n exhibited the most potent anti-inflammatory activity on decreasing IL-1β production with low cytotoxicity. Moreover, the further study found 7n could inhibit RANKL-induced osteoclast differentiation on bone marrow-derived macrophages (BMMs). These findings may provide a potential direction for the drug development of osteoarthritis." @default.
- W4317548786 created "2023-01-20" @default.
- W4317548786 creator A5022873764 @default.
- W4317548786 creator A5036915722 @default.
- W4317548786 creator A5039857643 @default.
- W4317548786 creator A5050852997 @default.
- W4317548786 creator A5051170599 @default.
- W4317548786 creator A5072186094 @default.
- W4317548786 creator A5080609124 @default.
- W4317548786 creator A5089554435 @default.
- W4317548786 date "2023-02-01" @default.
- W4317548786 modified "2023-10-16" @default.
- W4317548786 title "Synthesis and biological evaluation of pyrazole-fused oleanolic acid derivatives as novel inhibitors of inflammatory and osteoclast differentiation" @default.
- W4317548786 cites W2028469883 @default.
- W4317548786 cites W2042053670 @default.
- W4317548786 cites W2051886073 @default.
- W4317548786 cites W2085788584 @default.
- W4317548786 cites W2103495251 @default.
- W4317548786 cites W2260980970 @default.
- W4317548786 cites W2317083400 @default.
- W4317548786 cites W2342754223 @default.
- W4317548786 cites W2481203471 @default.
- W4317548786 cites W2595697424 @default.
- W4317548786 cites W2723557402 @default.
- W4317548786 cites W2765570325 @default.
- W4317548786 cites W2769865513 @default.
- W4317548786 cites W2779461820 @default.
- W4317548786 cites W2905013468 @default.
- W4317548786 cites W2944136715 @default.
- W4317548786 cites W3009853031 @default.
- W4317548786 cites W3110294417 @default.
- W4317548786 cites W3193501355 @default.
- W4317548786 cites W3197829241 @default.
- W4317548786 cites W4243722521 @default.
- W4317548786 cites W4317640168 @default.
- W4317548786 doi "https://doi.org/10.1016/j.bmc.2023.117177" @default.
- W4317548786 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36701870" @default.
- W4317548786 hasPublicationYear "2023" @default.
- W4317548786 type Work @default.
- W4317548786 citedByCount "0" @default.
- W4317548786 crossrefType "journal-article" @default.
- W4317548786 hasAuthorship W4317548786A5022873764 @default.
- W4317548786 hasAuthorship W4317548786A5036915722 @default.
- W4317548786 hasAuthorship W4317548786A5039857643 @default.
- W4317548786 hasAuthorship W4317548786A5050852997 @default.
- W4317548786 hasAuthorship W4317548786A5051170599 @default.
- W4317548786 hasAuthorship W4317548786A5072186094 @default.
- W4317548786 hasAuthorship W4317548786A5080609124 @default.
- W4317548786 hasAuthorship W4317548786A5089554435 @default.
- W4317548786 hasConcept C104317684 @default.
- W4317548786 hasConcept C109316439 @default.
- W4317548786 hasConcept C142724271 @default.
- W4317548786 hasConcept C185592680 @default.
- W4317548786 hasConcept C202751555 @default.
- W4317548786 hasConcept C204787440 @default.
- W4317548786 hasConcept C2776033226 @default.
- W4317548786 hasConcept C2777682936 @default.
- W4317548786 hasConcept C2778858181 @default.
- W4317548786 hasConcept C2779428903 @default.
- W4317548786 hasConcept C55493867 @default.
- W4317548786 hasConcept C57992300 @default.
- W4317548786 hasConcept C71240020 @default.
- W4317548786 hasConcept C71924100 @default.
- W4317548786 hasConcept C88045685 @default.
- W4317548786 hasConcept C98274493 @default.
- W4317548786 hasConceptScore W4317548786C104317684 @default.
- W4317548786 hasConceptScore W4317548786C109316439 @default.
- W4317548786 hasConceptScore W4317548786C142724271 @default.
- W4317548786 hasConceptScore W4317548786C185592680 @default.
- W4317548786 hasConceptScore W4317548786C202751555 @default.
- W4317548786 hasConceptScore W4317548786C204787440 @default.
- W4317548786 hasConceptScore W4317548786C2776033226 @default.
- W4317548786 hasConceptScore W4317548786C2777682936 @default.
- W4317548786 hasConceptScore W4317548786C2778858181 @default.
- W4317548786 hasConceptScore W4317548786C2779428903 @default.
- W4317548786 hasConceptScore W4317548786C55493867 @default.
- W4317548786 hasConceptScore W4317548786C57992300 @default.
- W4317548786 hasConceptScore W4317548786C71240020 @default.
- W4317548786 hasConceptScore W4317548786C71924100 @default.
- W4317548786 hasConceptScore W4317548786C88045685 @default.
- W4317548786 hasConceptScore W4317548786C98274493 @default.
- W4317548786 hasLocation W43175487861 @default.
- W4317548786 hasLocation W43175487862 @default.
- W4317548786 hasOpenAccess W4317548786 @default.
- W4317548786 hasPrimaryLocation W43175487861 @default.
- W4317548786 hasRelatedWork W1999468501 @default.
- W4317548786 hasRelatedWork W2002869234 @default.
- W4317548786 hasRelatedWork W2158870866 @default.
- W4317548786 hasRelatedWork W2352162483 @default.
- W4317548786 hasRelatedWork W2373469758 @default.
- W4317548786 hasRelatedWork W2387319543 @default.
- W4317548786 hasRelatedWork W2387808297 @default.
- W4317548786 hasRelatedWork W3004121057 @default.
- W4317548786 hasRelatedWork W3186983543 @default.
- W4317548786 hasRelatedWork W4317548786 @default.
- W4317548786 hasVolume "80" @default.
- W4317548786 isParatext "false" @default.
- W4317548786 isRetracted "false" @default.