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• W4317553697 abstract "Microbial endophytes often play very vital roles in the growth and development of the host-plant and are also found to exhibit the production of biologically active secondary metabolites like alkaloids, flavonoids, quinols, phenols, terpenes, polyketones, steroids, polysaccharides, peptides, etc. A number of such compounds have wide pharmaceutical and therapeutic implementations for having antioxidant, antimicrobial, anti-inflammatory, antilipidemic, antihypertensive, antithrombotic, antiatherogenic, antidiabetic, and anticancer properties. Some endophytes are found to produce the identical secondary metabolites as their host plant. There are instances of bioactive compounds that are coproduced by the plants as well as their respective endophytes like, the anticancer drug camptothecin or the insecticide azadirachtin. Studies showed that the symbiotic relationship between endophytic organisms and their respective host results in the production of diverse and larger quantity of bioactive secondary metabolites in comparison to their close-relatives of other habitats. There are instances of antimicrobial activity of endophytic Penicillium sp. and Fusarium moniliforme against multidrug resistant (MDR) human pathogens like Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Salmonella typhi. Lately, a number of endo-symbiotic actinomycetes were discovered from several mangrove plants which show antibacterial activity against pathogens like Acinetobacter baumannii, Enterococcus faecalis, E. coli, K. pneumoniae, P. aeruginosa, and S. aureus which are resistant to vancomycin, methicillin, and carbapenem antibiotics. With the growing cases of drug resistance in pathogens, there is a persistent urgency to discover novel antibiotics against such MDR organisms. Exploration of such symbiotic microorganisms would assist in the probable isolation and production of novel bioactive compounds." @default.
• W4317553697 created "2023-01-20" @default.
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• W4317553697 date "2023-01-01" @default.
• W4317553697 modified "2023-09-25" @default.
• W4317553697 title "Endophytic microbes: A potential source of bioactive metabolites with therapeutic values" @default.
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• W4317553697 doi "https://doi.org/10.1016/b978-0-323-91245-7.00004-3" @default.
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