FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4317556596> ?p ?o ?g. }

• W4317556596 abstract "Abstract Real-time multi-channel measurements of tonic serotonin (5-hydroxytryptamine, 5-HT) concentrations across different brain regions are of utmost importance to the understanding of 5-HT’s role in anxiety, depression, and impulse control disorders, which will improve the diagnosis and treatment of these neuropsychiatric illnesses. Chronic sampling of 5-HT is critical in tracking disease development as well as the time course of pharmacological treatments. Despite their value, in vivo chronic multi-site measurements of 5-HT have not been reported. To fill this technological gap, we batch fabricated implantable glassy carbon (GC) microelectrode arrays (MEAs) on a flexible SU-8 substrate to provide an electrochemically stable and biocompatible device/tissue interface. Then, to achieve multi-site detection of tonic 5-HT concentrations, we incorporated the poly(3,4-ethylenedioxythiophene)/functionalized carbon nanotube (PEDOT/CNT) coating on the GC microelectrodes in combination with a new square wave voltammetry (SWV) approach, optimized for selective 5-HT measurement. In vitro , the PEDOT/CNT coated GC microelectrodes achieved high sensitivity towards 5-HT, good fouling resistance in the presence of 5-HT, and excellent selectivity towards the most common neurochemical interferents. In vivo , our PEDOT/CNT-coated GC MEAs were able to successfully detect basal 5-HT concentrations at different locations of the CA2 hippocampal region of mice in both anesthetized and awake head-fixed conditions. Furthermore, the implanted PEDOT/CNT-coated MEA achieved stable detection of tonic 5-HT concentrations for one week. Finally, histology data in the hippocampus shows reduced tissue damage and inflammatory responses compared to stiff silicon probes. To the best of our knowledge, this PEDOT/CNT-coated GC MEA is the first implantable flexible multisite sensor capable of chronic in vivo multi-site sensing of tonic 5-HT. This implantable MEA can be custom-designed according to specific brain region of interests and research questions, with the potential to combine electrophysiology recording and multiple analyte sensing to maximize our understanding of neurochemistry. Highlights PEDOT/CNT-coated GC microelectrodes enabled sensitive and selective tonic detection of serotonin (5-HT) using a new square wave voltammetry (SWV) approach PEDOT/CNT-coated GC MEAs achieved multi-site in vivo 5-HT tonic detection for one week. Flexible MEAs lead to reduced tissue damage and inflammation compared to stiff silicon probes." @default.
• W4317556596 created "2023-01-20" @default.
• W4317556596 creator A5004989371 @default.
• W4317556596 creator A5028921090 @default.
• W4317556596 creator A5030462307 @default.
• W4317556596 creator A5054547780 @default.
• W4317556596 creator A5065445717 @default.
• W4317556596 creator A5073799773 @default.
• W4317556596 creator A5084264585 @default.
• W4317556596 date "2023-01-20" @default.
• W4317556596 modified "2023-09-27" @default.
• W4317556596 title "Implantable flexible multielectrode arrays for multi-site sensing of serotonin tonic levels" @default.
• W4317556596 cites W1484549127 @default.
• W4317556596 cites W1864522064 @default.
• W4317556596 cites W1904102679 @default.
• W4317556596 cites W1968920506 @default.
• W4317556596 cites W1972336848 @default.
• W4317556596 cites W1972966292 @default.
• W4317556596 cites W1986634819 @default.
• W4317556596 cites W1986698038 @default.
• W4317556596 cites W1991920290 @default.
• W4317556596 cites W1993348868 @default.
• W4317556596 cites W2008663231 @default.
• W4317556596 cites W2009827658 @default.
• W4317556596 cites W2015370536 @default.
• W4317556596 cites W2015898149 @default.
• W4317556596 cites W2016485258 @default.
• W4317556596 cites W2020215984 @default.
• W4317556596 cites W2020879608 @default.
• W4317556596 cites W2021060120 @default.
• W4317556596 cites W2030046699 @default.
• W4317556596 cites W2031775832 @default.
• W4317556596 cites W2031930458 @default.
• W4317556596 cites W2048767020 @default.
• W4317556596 cites W2049227843 @default.
• W4317556596 cites W2049856234 @default.
• W4317556596 cites W2051376367 @default.
• W4317556596 cites W2052710610 @default.
• W4317556596 cites W2061680435 @default.
• W4317556596 cites W2068419155 @default.
• W4317556596 cites W2072038209 @default.
• W4317556596 cites W2074880343 @default.
• W4317556596 cites W2076950982 @default.
• W4317556596 cites W2079402691 @default.
• W4317556596 cites W2090157379 @default.
• W4317556596 cites W2101656718 @default.
• W4317556596 cites W2103303614 @default.
• W4317556596 cites W2120968628 @default.
• W4317556596 cites W2123023667 @default.
• W4317556596 cites W2124984580 @default.
• W4317556596 cites W2127493422 @default.
• W4317556596 cites W2127567317 @default.
• W4317556596 cites W2143287453 @default.
• W4317556596 cites W2149942134 @default.
• W4317556596 cites W2220017603 @default.
• W4317556596 cites W2323210774 @default.
• W4317556596 cites W2327475182 @default.
• W4317556596 cites W2487723089 @default.
• W4317556596 cites W2515934579 @default.
• W4317556596 cites W2538076117 @default.
• W4317556596 cites W2561661981 @default.
• W4317556596 cites W2571419752 @default.
• W4317556596 cites W2584939606 @default.
• W4317556596 cites W2588766868 @default.
• W4317556596 cites W2619143829 @default.
• W4317556596 cites W2727117825 @default.
• W4317556596 cites W2735381496 @default.
• W4317556596 cites W2744428892 @default.
• W4317556596 cites W2757396115 @default.
• W4317556596 cites W2794013297 @default.
• W4317556596 cites W2883506190 @default.
• W4317556596 cites W2911873702 @default.
• W4317556596 cites W2927001375 @default.
• W4317556596 cites W2940465020 @default.
• W4317556596 cites W2944969693 @default.
• W4317556596 cites W2946386151 @default.
• W4317556596 cites W2952727694 @default.
• W4317556596 cites W2969853012 @default.
• W4317556596 cites W2972687412 @default.
• W4317556596 cites W2979791455 @default.
• W4317556596 cites W2988179174 @default.
• W4317556596 cites W2997601619 @default.
• W4317556596 cites W3005893828 @default.
• W4317556596 cites W3008141868 @default.
• W4317556596 cites W3009445823 @default.
• W4317556596 cites W3023008267 @default.
• W4317556596 cites W3033491777 @default.
• W4317556596 cites W3042822015 @default.
• W4317556596 cites W3095192094 @default.
• W4317556596 cites W3110405104 @default.
• W4317556596 cites W3163437875 @default.
• W4317556596 cites W3172307071 @default.
• W4317556596 cites W3195388948 @default.
• W4317556596 cites W3216364984 @default.
• W4317556596 cites W323642578 @default.
• W4317556596 cites W4206051586 @default.
• W4317556596 cites W4233054149 @default.
• W4317556596 cites W4281640683 @default.
• W4317556596 cites W4282836849 @default.
• W4317556596 cites W4285803389 @default.

• next