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- W4317565593 abstract "Abstract Background: The percentage of positive cores (PPC) is increasingly recognized as a prognostic factor in prostate cancer. However, the usefulness of PPC for patients undergoing androgen deprivation therapy (ADT) and high-risk group has not been adequately studied. Methods: A retrospective analysis was conducted of 255 patients who underwent prostate biopsy (all-case group). We examined the efficacy of PPC as a prognostic biomarker. Results: Eighty-nine patients were treated with ADT alone (ADT group), and 107 patients were classified as high-risk (high-risk group). The median duration of follow-up was 112.4 months, 85.3 months, and 110.0 months for the all-case group, ADT group, and high-risk group, respectively. Patients with PPC >60% had significantly shorter prostate cancer-specific survival (CSS) and castration-resistant prostate cancer-free survival (CFS) in the all-case group and ADT group. In high-risk group, patients with PPC >60% had shorter CFS but no difference in CSS. Multivariate analysis showed that significant independent predictors of prostate CSS were the presence of metastasis at diagnosis and PPC >60% in the all-case group and ADT group. Conclusions: This study demonstrates that PPC may be a prognostic factor in ADT treatment and high-risk patients." @default.
- W4317565593 created "2023-01-21" @default.
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- W4317565593 date "2023-01-20" @default.
- W4317565593 modified "2023-10-17" @default.
- W4317565593 title "Role of positive biopsy core ratio in prostate cancer patients" @default.
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- W4317565593 doi "https://doi.org/10.21203/rs.3.rs-2486096/v1" @default.
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