Matches in SemOpenAlex for { <https://semopenalex.org/work/W4317567399> ?p ?o ?g. }
- W4317567399 endingPage "481" @default.
- W4317567399 startingPage "471" @default.
- W4317567399 abstract "Fibrosis describes a dysregulated tissue remodelling response to persistent cellular injury and is the final pathological consequence of many chronic diseases that affect the liver, kidney and lung. Nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase (NOX) enzymes produce reactive oxygen species (ROS) as their primary function. ROS derived from NOX1 and NOX4 are key mediators of liver, kidney and lung fibrosis. Setanaxib (GKT137831) is a first-in-class, dual inhibitor of NOX1/4 and is the first NOX inhibitor to progress to clinical trial investigation. The anti-fibrotic effects of setanaxib in liver, kidney and lung fibrosis are supported by multiple lines of pre-clinical evidence. However, despite advances in our understanding, the precise roles of NOX1/4 in fibrosis require further investigation. Additionally, there is a translational gap between the pre-clinical observations of setanaxib to date and the applicability of these to human patients within a clinical setting. This narrative review critically examines the role of NOX1/4 in liver, kidney and lung fibrosis, alongside the available evidence investigating setanaxib as a therapeutic agent in pre-clinical models of disease. We discuss the potential clinical translatability of this pre-clinical evidence, which provides rationale to explore NOX1/4 inhibition by setanaxib across various fibrotic pathologies in clinical trials involving human patients." @default.
- W4317567399 created "2023-01-21" @default.
- W4317567399 creator A5012603472 @default.
- W4317567399 creator A5018173206 @default.
- W4317567399 creator A5037869894 @default.
- W4317567399 creator A5081550304 @default.
- W4317567399 date "2023-01-19" @default.
- W4317567399 modified "2023-09-30" @default.
- W4317567399 title "<scp>Pre‐clinical</scp> evidence of a dual <scp>NADPH</scp> oxidase 1/4 inhibitor (setanaxib) in liver, kidney and lung fibrosis" @default.
- W4317567399 cites W185233189 @default.
- W4317567399 cites W1867325796 @default.
- W4317567399 cites W1905740399 @default.
- W4317567399 cites W1915485606 @default.
- W4317567399 cites W1966672647 @default.
- W4317567399 cites W1980325398 @default.
- W4317567399 cites W1990038383 @default.
- W4317567399 cites W1990377623 @default.
- W4317567399 cites W2024340931 @default.
- W4317567399 cites W2028658650 @default.
- W4317567399 cites W2033147946 @default.
- W4317567399 cites W2045142779 @default.
- W4317567399 cites W2045307635 @default.
- W4317567399 cites W2056269088 @default.
- W4317567399 cites W2064307892 @default.
- W4317567399 cites W2067673857 @default.
- W4317567399 cites W2077006626 @default.
- W4317567399 cites W2079723429 @default.
- W4317567399 cites W2081975963 @default.
- W4317567399 cites W2085128107 @default.
- W4317567399 cites W2085548242 @default.
- W4317567399 cites W2087467372 @default.
- W4317567399 cites W2098414680 @default.
- W4317567399 cites W2102619095 @default.
- W4317567399 cites W2105099973 @default.
- W4317567399 cites W2114785705 @default.
- W4317567399 cites W2117261670 @default.
- W4317567399 cites W2124445444 @default.
- W4317567399 cites W2127400388 @default.
- W4317567399 cites W2169794895 @default.
- W4317567399 cites W2207348770 @default.
- W4317567399 cites W2344653992 @default.
- W4317567399 cites W2414686680 @default.
- W4317567399 cites W2462113069 @default.
- W4317567399 cites W2463961540 @default.
- W4317567399 cites W2584650121 @default.
- W4317567399 cites W2739471295 @default.
- W4317567399 cites W2760932249 @default.
- W4317567399 cites W2777958821 @default.
- W4317567399 cites W2782893368 @default.
- W4317567399 cites W2783685618 @default.
- W4317567399 cites W2899724159 @default.
- W4317567399 cites W2905740763 @default.
- W4317567399 cites W2943334785 @default.
- W4317567399 cites W2956481235 @default.
- W4317567399 cites W2963234714 @default.
- W4317567399 cites W2983451112 @default.
- W4317567399 cites W2997839314 @default.
- W4317567399 cites W3006379039 @default.
- W4317567399 cites W3009594152 @default.
- W4317567399 cites W3012022276 @default.
- W4317567399 cites W3028868818 @default.
- W4317567399 cites W3041591452 @default.
- W4317567399 cites W3109793392 @default.
- W4317567399 cites W3113455426 @default.
- W4317567399 cites W3169276191 @default.
- W4317567399 cites W3197357594 @default.
- W4317567399 cites W3201043780 @default.
- W4317567399 cites W4255712601 @default.
- W4317567399 cites W4282971572 @default.
- W4317567399 cites W4293722646 @default.
- W4317567399 cites W4317567399 @default.
- W4317567399 cites W985842495 @default.
- W4317567399 doi "https://doi.org/10.1111/jcmm.17649" @default.
- W4317567399 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36658776" @default.
- W4317567399 hasPublicationYear "2023" @default.
- W4317567399 type Work @default.
- W4317567399 citedByCount "5" @default.
- W4317567399 countsByYear W43175673992023 @default.
- W4317567399 crossrefType "journal-article" @default.
- W4317567399 hasAuthorship W4317567399A5012603472 @default.
- W4317567399 hasAuthorship W4317567399A5018173206 @default.
- W4317567399 hasAuthorship W4317567399A5037869894 @default.
- W4317567399 hasAuthorship W4317567399A5081550304 @default.
- W4317567399 hasBestOaLocation W43175673991 @default.
- W4317567399 hasConcept C126322002 @default.
- W4317567399 hasConcept C142724271 @default.
- W4317567399 hasConcept C181199279 @default.
- W4317567399 hasConcept C2776061955 @default.
- W4317567399 hasConcept C2776151105 @default.
- W4317567399 hasConcept C2777714996 @default.
- W4317567399 hasConcept C2777989768 @default.
- W4317567399 hasConcept C2778653478 @default.
- W4317567399 hasConcept C2779719074 @default.
- W4317567399 hasConcept C2779765511 @default.
- W4317567399 hasConcept C2780091579 @default.
- W4317567399 hasConcept C2780559512 @default.
- W4317567399 hasConcept C38485361 @default.
- W4317567399 hasConcept C55493867 @default.