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- W4317582173 abstract "Abstract Dopamine axons are the only axons known to grow during adolescence. Here, using rodent models, we examined how two proteins, Netrin-1 and its receptor, UNC5C, guide dopamine axons towards the prefrontal cortex and shape behaviour. We demonstrate in mice ( Mus musculus ) that dopamine axons reach the cortex through a transient gradient of Netrin-1 expressing cells – disrupting this gradient reroutes axons away from their target. Using a seasonal model (Siberian hamsters; Phodopus sungorus ) we find that mesocortical dopamine development can be regulated by a natural environmental cue (daylength) in a sexually dimorphic manner – delayed in males, but advanced in females. The timings of dopamine axon growth and UNC5C expression are always phase-locked. Adolescence is an ill-defined, transitional period; we pinpoint neurodevelopmental markers underlying this period." @default.
- W4317582173 created "2023-01-21" @default.
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- W4317582173 date "2023-01-20" @default.
- W4317582173 modified "2023-09-27" @default.
- W4317582173 title "The scheduling of adolescence with Netrin-1 and UNC5C" @default.
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- W4317582173 doi "https://doi.org/10.1101/2023.01.19.521267" @default.
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