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- W4317584510 abstract "Abstract The early detection of anti‐asparaginase biomarker can facilitate timely modification of asparaginase chemotherapy, thereby avoiding serious complications. Herein we describe the preparation of a novel electrochemical biosensing interface for rapid detection of anti‐asparaginase in the picomolar range (1–10 000 pM). Coimmobilization of ferrocene and asparaginase on a carbon interface (via diazonium grafting) facilitates transduction through attenuation of the surface‐bound ferrocene redox couple. The limit of detection of 0.8 pM for this point‐of‐care applicable method compares favourably to that of traditional faradaic assaying (2.0 pM) where transduction occurs by the target blocking the diffusion of the solution redox probe [Fe(CN) 6 ] 3−/4− ." @default.
- W4317584510 created "2023-01-21" @default.
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- W4317584510 date "2023-02-10" @default.
- W4317584510 modified "2023-10-14" @default.
- W4317584510 title "Electrochemical detection of asparaginase antibodies using bifunctionalized carbon interfaces" @default.
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- W4317584510 doi "https://doi.org/10.1002/elan.202200456" @default.
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