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- W4317602004 abstract "Undoubtedly, genetic factors play an important role in susceptibility and resistance to COVID-19. In this study, we conducted the GWAS analysis. Out of 15,489,173 SNPs, we identified 18,191 significant SNPs for severe and 11,799 SNPs for resistant phenotype, showing that a great number of loci were significant in different COVID-19 representations. The majority of variants were synonymous (60.56% for severe, 58.46% for resistant phenotype) or located in introns (55.77% for severe, 59.83% for resistant phenotype). We identified the most significant SNPs for a severe outcome (in AJAP1 intron) and for COVID resistance (in FIG4 intron). We found no missense variants with a potential causal function on resistance to COVID-19; however, two missense variants were determined as significant a severe phenotype (in PM20D1 and LRP4 exons). None of the aforementioned SNPs and missense variants found in this study have been previously associated with COVID-19." @default.
- W4317602004 created "2023-01-21" @default.
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- W4317602004 date "2023-01-20" @default.
- W4317602004 modified "2023-09-25" @default.
- W4317602004 title "Better safe than sorry—Whole-genome sequencing indicates that missense variants are significant in susceptibility to COVID-19" @default.
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- W4317602004 doi "https://doi.org/10.1371/journal.pone.0279356" @default.
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