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- W4317605830 abstract "The excitatory/inhibitory (E/I) imbalance hypothesis posits that imbalance between excitatory (glutamatergic) and inhibitory (GABAergic) mechanisms underlies the behavioral characteristics of autism. However, how E/I imbalance arises and how it may differ across autism symptomatology and brain regions is not well understood. We used innovative analysis methods-combining competitive gene-set analysis and gene-expression profiles in relation to cortical thickness (CT) to investigate relationships between genetic variance, brain structure and autism symptomatology of participants from the AIMS-2-TRIALS LEAP cohort (autism = 359, male/female = 258/101; neurotypical control participants = 279, male/female = 178/101) aged 6-30 years. Using competitive gene-set analyses, we investigated whether aggregated genetic variation in glutamate and GABA gene-sets could be associated with behavioral measures of autism symptoms and brain structural variation. Further, using the same gene-sets, we corelated expression profiles throughout the cortex with differences in CT between autistic and neurotypical control participants, as well as in separate sensory subgroups. The glutamate gene-set was associated with all autism symptom severity scores on the Autism Diagnostic Observation Schedule-2 (ADOS-2) and the Autism Diagnostic Interview-Revised (ADI-R) within the autistic group. In adolescents and adults, brain regions with greater gene-expression of glutamate and GABA genes showed greater differences in CT between autistic and neurotypical control participants although in opposing directions. Additionally, the gene expression profiles were associated with CT profiles in separate sensory subgroups. Our results suggest complex relationships between E/I related genetics and autism symptom profiles as well as brain structure alterations, where there may be differential roles for glutamate and GABA." @default.
- W4317605830 created "2023-01-21" @default.
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- W4317605830 date "2023-01-21" @default.
- W4317605830 modified "2023-10-17" @default.
- W4317605830 title "Excitatory/inhibitory imbalance in autism: the role of glutamate and GABA gene-sets in symptoms and cortical brain structure" @default.
- W4317605830 cites W1541267199 @default.
- W4317605830 cites W1577082455 @default.
- W4317605830 cites W1613369435 @default.
- W4317605830 cites W1806618908 @default.
- W4317605830 cites W1841346055 @default.
- W4317605830 cites W1979041721 @default.
- W4317605830 cites W2040268226 @default.
- W4317605830 cites W2044186109 @default.
- W4317605830 cites W2049577872 @default.
- W4317605830 cites W2051314902 @default.
- W4317605830 cites W2055655674 @default.
- W4317605830 cites W2056802956 @default.
- W4317605830 cites W2077755020 @default.
- W4317605830 cites W2083934986 @default.
- W4317605830 cites W2101135654 @default.
- W4317605830 cites W2105467005 @default.
- W4317605830 cites W2107555020 @default.
- W4317605830 cites W2110437310 @default.
- W4317605830 cites W2111613011 @default.
- W4317605830 cites W2117547538 @default.
- W4317605830 cites W2123523993 @default.
- W4317605830 cites W2129032286 @default.
- W4317605830 cites W2139852368 @default.
- W4317605830 cites W2144446993 @default.
- W4317605830 cites W2147450423 @default.
- W4317605830 cites W2151721316 @default.
- W4317605830 cites W2152849583 @default.
- W4317605830 cites W2155856343 @default.
- W4317605830 cites W2157270343 @default.
- W4317605830 cites W2167868121 @default.
- W4317605830 cites W2299693096 @default.
- W4317605830 cites W2320983896 @default.
- W4317605830 cites W2341504574 @default.
- W4317605830 cites W2510973425 @default.
- W4317605830 cites W2520088250 @default.
- W4317605830 cites W2560217233 @default.
- W4317605830 cites W2570496985 @default.
- W4317605830 cites W2599116301 @default.
- W4317605830 cites W2616029603 @default.
- W4317605830 cites W2616752168 @default.
- W4317605830 cites W2617984397 @default.
- W4317605830 cites W2623899914 @default.
- W4317605830 cites W2625516444 @default.
- W4317605830 cites W2732740969 @default.
- W4317605830 cites W2742494644 @default.
- W4317605830 cites W2758053316 @default.
- W4317605830 cites W2768745187 @default.
- W4317605830 cites W2804295544 @default.
- W4317605830 cites W2805439175 @default.
- W4317605830 cites W2889179699 @default.
- W4317605830 cites W2891652723 @default.
- W4317605830 cites W2894721371 @default.
- W4317605830 cites W2913959566 @default.
- W4317605830 cites W2914482125 @default.
- W4317605830 cites W2950447704 @default.
- W4317605830 cites W2955503846 @default.
- W4317605830 cites W2970058996 @default.
- W4317605830 cites W2990424445 @default.
- W4317605830 cites W2998725968 @default.
- W4317605830 cites W3000694673 @default.
- W4317605830 cites W3011266331 @default.
- W4317605830 cites W3025763447 @default.
- W4317605830 cites W3028433604 @default.
- W4317605830 cites W3080158422 @default.
- W4317605830 cites W3082052672 @default.
- W4317605830 cites W3112375597 @default.
- W4317605830 cites W3169126825 @default.
- W4317605830 cites W4205105949 @default.
- W4317605830 cites W4206405722 @default.
- W4317605830 cites W4241074797 @default.
- W4317605830 cites W4243204593 @default.