FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4317614462> ?p ?o ?g. }

• W4317614462 abstract "Abstract Background To predict and validate the potential mechanism by which Gynura divaricata (GD) functions in the treatment of diabetic foot (DF). Methods The main chemical constituents of GD were identified by reviewing the literature, the traditional Chinese medicine database platform (TCMIP) and the BATMAN-TCM platform. DF disease targets were identified with the GeneCards database, and the compound-target network was constructed by using the intersection of drugs and disease. The STRING platform was used to construct the protein–protein interaction (PPI) network, and Cytoscape 3.7.2 software was used to visualize the results. Moreover, the Metascape database was used for Gene Ontology (GO) enrichment analyses and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses. Molecular docking of the active ingredients of GD and core protein targets of DF was performed using AutoDock software. Finally, the predicted results were preliminarily verified with experiments. Results A total of 140 potential targets of GD were identified and associated with DF. According to the PPI network analysis, GD accelerated DF wound healing, and the mechanism may be related to proteins such as AKT1, TP53, IL6, CASP3, TNF, and VEGFA. GO and KEGG enrichment analyses indicated that GD may play a role in the treatment of diabetic foot by affecting various signaling pathways. Molecular docking results showed that the proteins AKT1, TP53, IL6, CASP3, TNF, and VEGFA were closely associated with the components of GD. The animal experiments showed that GD reduced the levels of IL-6 and TNF-α and increased the mRNA and protein expression of VEGFA in rats with DF. Conclusions GD regulates multiple targets and multiple pathways to promote wound healing in DF." @default.
• W4317614462 created "2023-01-21" @default.
• W4317614462 creator A5004779717 @default.
• W4317614462 creator A5033684035 @default.
• W4317614462 creator A5046372467 @default.
• W4317614462 creator A5057465940 @default.
• W4317614462 creator A5063773713 @default.
• W4317614462 date "2023-01-20" @default.
• W4317614462 modified "2023-10-18" @default.
• W4317614462 title "Exploring the mechanism by which aqueous Gynura divaricata inhibits diabetic foot based on network pharmacology, molecular docking and experimental verification" @default.
• W4317614462 cites W1080273216 @default.
• W4317614462 cites W1973343864 @default.
• W4317614462 cites W2000054651 @default.
• W4317614462 cites W2021376393 @default.
• W4317614462 cites W2039762060 @default.
• W4317614462 cites W2060497286 @default.
• W4317614462 cites W2071764534 @default.
• W4317614462 cites W21269893 @default.
• W4317614462 cites W2159675211 @default.
• W4317614462 cites W2217355468 @default.
• W4317614462 cites W2341062931 @default.
• W4317614462 cites W2368011348 @default.
• W4317614462 cites W2561727131 @default.
• W4317614462 cites W2592515852 @default.
• W4317614462 cites W2785417003 @default.
• W4317614462 cites W2900569176 @default.
• W4317614462 cites W2928665623 @default.
• W4317614462 cites W2975412751 @default.
• W4317614462 cites W2983012744 @default.
• W4317614462 cites W2990451863 @default.
• W4317614462 cites W3005722875 @default.
• W4317614462 cites W3040813760 @default.
• W4317614462 cites W3049054905 @default.
• W4317614462 cites W3067485602 @default.
• W4317614462 cites W3097657996 @default.
• W4317614462 cites W3109618534 @default.
• W4317614462 cites W3126655217 @default.
• W4317614462 cites W3134123890 @default.
• W4317614462 cites W3158360048 @default.
• W4317614462 cites W3162329380 @default.
• W4317614462 cites W3165061718 @default.
• W4317614462 cites W3190978774 @default.
• W4317614462 cites W4200483069 @default.
• W4317614462 cites W4206429440 @default.
• W4317614462 cites W4229526190 @default.
• W4317614462 doi "https://doi.org/10.1186/s10020-023-00605-w" @default.
• W4317614462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36670362" @default.
• W4317614462 hasPublicationYear "2023" @default.
• W4317614462 type Work @default.
• W4317614462 citedByCount "0" @default.
• W4317614462 crossrefType "journal-article" @default.
• W4317614462 hasAuthorship W4317614462A5004779717 @default.
• W4317614462 hasAuthorship W4317614462A5033684035 @default.
• W4317614462 hasAuthorship W4317614462A5046372467 @default.
• W4317614462 hasAuthorship W4317614462A5057465940 @default.
• W4317614462 hasAuthorship W4317614462A5063773713 @default.
• W4317614462 hasBestOaLocation W43176144621 @default.
• W4317614462 hasConcept C104317684 @default.
• W4317614462 hasConcept C121332964 @default.
• W4317614462 hasConcept C150194340 @default.
• W4317614462 hasConcept C152724338 @default.
• W4317614462 hasConcept C154137905 @default.
• W4317614462 hasConcept C159110408 @default.
• W4317614462 hasConcept C185592680 @default.
• W4317614462 hasConcept C2779446555 @default.
• W4317614462 hasConcept C2780035454 @default.
• W4317614462 hasConcept C2987395477 @default.
• W4317614462 hasConcept C41685203 @default.
• W4317614462 hasConcept C55493867 @default.
• W4317614462 hasConcept C60644358 @default.
• W4317614462 hasConcept C62478195 @default.
• W4317614462 hasConcept C62520636 @default.
• W4317614462 hasConcept C70721500 @default.
• W4317614462 hasConcept C71924100 @default.
• W4317614462 hasConcept C86554907 @default.
• W4317614462 hasConcept C86803240 @default.
• W4317614462 hasConcept C89611455 @default.
• W4317614462 hasConcept C98274493 @default.
• W4317614462 hasConceptScore W4317614462C104317684 @default.
• W4317614462 hasConceptScore W4317614462C121332964 @default.
• W4317614462 hasConceptScore W4317614462C150194340 @default.
• W4317614462 hasConceptScore W4317614462C152724338 @default.
• W4317614462 hasConceptScore W4317614462C154137905 @default.
• W4317614462 hasConceptScore W4317614462C159110408 @default.
• W4317614462 hasConceptScore W4317614462C185592680 @default.
• W4317614462 hasConceptScore W4317614462C2779446555 @default.
• W4317614462 hasConceptScore W4317614462C2780035454 @default.
• W4317614462 hasConceptScore W4317614462C2987395477 @default.
• W4317614462 hasConceptScore W4317614462C41685203 @default.
• W4317614462 hasConceptScore W4317614462C55493867 @default.
• W4317614462 hasConceptScore W4317614462C60644358 @default.
• W4317614462 hasConceptScore W4317614462C62478195 @default.
• W4317614462 hasConceptScore W4317614462C62520636 @default.
• W4317614462 hasConceptScore W4317614462C70721500 @default.
• W4317614462 hasConceptScore W4317614462C71924100 @default.
• W4317614462 hasConceptScore W4317614462C86554907 @default.
• W4317614462 hasConceptScore W4317614462C86803240 @default.
• W4317614462 hasConceptScore W4317614462C89611455 @default.
• W4317614462 hasConceptScore W4317614462C98274493 @default.
• W4317614462 hasFunder F4320321550 @default.

• next