Matches in SemOpenAlex for { <https://semopenalex.org/work/W4317630247> ?p ?o ?g. }
- W4317630247 abstract "The HIV-1 reservoirs harbor the latent proviruses that are integrated into the host genome. It is a challenging task to eradicate the proviruses in order to achieve an HIV cure. We have described a strategy for the clearance of HIV-1 infection through selective elimination of host cells harboring replication-competent HIV (SECH), by inhibition of autophagy and promotion of apoptosis during viral re-activation. HIV-1 can infect various CD4 + T cell subsets, but it is not known whether the SECH approach is equally effective in targeting HIV-1 reservoirs in these different subsets in vivo . In a humanized mouse model, we found that treatments of HIV-1 infection by suppressive antiretroviral therapy (ART) led to the establishment of latent HIV reservoirs in naïve, central memory and effector memory T cells. Moreover, SECH treatments could clear latent HIV-1 reservoirs in these different T cell subsets of humanized mice. Co-culture studies showed that T cell subsets latently infected by HIV-1, but not uninfected bystander cells, were susceptible to cell death induced by SECH treatments. Our study suggests that the SECH strategy is effective for specific targeting of latent HIV-1 reservoirs in different T cell subsets." @default.
- W4317630247 created "2023-01-21" @default.
- W4317630247 creator A5012718640 @default.
- W4317630247 creator A5015565662 @default.
- W4317630247 creator A5042817178 @default.
- W4317630247 creator A5052024256 @default.
- W4317630247 date "2023-01-20" @default.
- W4317630247 modified "2023-10-17" @default.
- W4317630247 title "Targeting HIV-1 reservoirs in T cell subsets" @default.
- W4317630247 cites W1812170084 @default.
- W4317630247 cites W1937243106 @default.
- W4317630247 cites W1975783419 @default.
- W4317630247 cites W1981080347 @default.
- W4317630247 cites W1989114743 @default.
- W4317630247 cites W1989183132 @default.
- W4317630247 cites W1992036920 @default.
- W4317630247 cites W1996295511 @default.
- W4317630247 cites W2034632639 @default.
- W4317630247 cites W2044273929 @default.
- W4317630247 cites W2046172596 @default.
- W4317630247 cites W2049653440 @default.
- W4317630247 cites W2052618262 @default.
- W4317630247 cites W2052922936 @default.
- W4317630247 cites W2060829964 @default.
- W4317630247 cites W2069644313 @default.
- W4317630247 cites W2076436994 @default.
- W4317630247 cites W2090646713 @default.
- W4317630247 cites W2092991947 @default.
- W4317630247 cites W2094434723 @default.
- W4317630247 cites W2097821680 @default.
- W4317630247 cites W2102698854 @default.
- W4317630247 cites W2105495668 @default.
- W4317630247 cites W2113206573 @default.
- W4317630247 cites W2122310985 @default.
- W4317630247 cites W2124114936 @default.
- W4317630247 cites W2131638827 @default.
- W4317630247 cites W2131924915 @default.
- W4317630247 cites W2136500130 @default.
- W4317630247 cites W2139250164 @default.
- W4317630247 cites W2145254159 @default.
- W4317630247 cites W2157887699 @default.
- W4317630247 cites W2168632005 @default.
- W4317630247 cites W2169033726 @default.
- W4317630247 cites W2171105241 @default.
- W4317630247 cites W2312533919 @default.
- W4317630247 cites W2320010059 @default.
- W4317630247 cites W2402644849 @default.
- W4317630247 cites W2598871150 @default.
- W4317630247 cites W2602545542 @default.
- W4317630247 cites W2766409016 @default.
- W4317630247 cites W2766543637 @default.
- W4317630247 cites W2789029405 @default.
- W4317630247 cites W2806432542 @default.
- W4317630247 cites W2807438673 @default.
- W4317630247 cites W2902374219 @default.
- W4317630247 cites W2903822207 @default.
- W4317630247 cites W2908210986 @default.
- W4317630247 cites W2948810228 @default.
- W4317630247 cites W2985355380 @default.
- W4317630247 cites W2994951996 @default.
- W4317630247 cites W3003221987 @default.
- W4317630247 cites W3048319352 @default.
- W4317630247 cites W3048391265 @default.
- W4317630247 cites W3089079155 @default.
- W4317630247 cites W3134979671 @default.
- W4317630247 cites W3216073603 @default.
- W4317630247 cites W4226328621 @default.
- W4317630247 cites W4236714219 @default.
- W4317630247 doi "https://doi.org/10.3389/fimmu.2023.1087923" @default.
- W4317630247 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36742330" @default.
- W4317630247 hasPublicationYear "2023" @default.
- W4317630247 type Work @default.
- W4317630247 citedByCount "0" @default.
- W4317630247 crossrefType "journal-article" @default.
- W4317630247 hasAuthorship W4317630247A5012718640 @default.
- W4317630247 hasAuthorship W4317630247A5015565662 @default.
- W4317630247 hasAuthorship W4317630247A5042817178 @default.
- W4317630247 hasAuthorship W4317630247A5052024256 @default.
- W4317630247 hasBestOaLocation W43176302471 @default.
- W4317630247 hasConcept C140704245 @default.
- W4317630247 hasConcept C1491633281 @default.
- W4317630247 hasConcept C159047783 @default.
- W4317630247 hasConcept C190283241 @default.
- W4317630247 hasConcept C19106626 @default.
- W4317630247 hasConcept C203014093 @default.
- W4317630247 hasConcept C207001950 @default.
- W4317630247 hasConcept C2522874641 @default.
- W4317630247 hasConcept C26291073 @default.
- W4317630247 hasConcept C2776090121 @default.
- W4317630247 hasConcept C2776156784 @default.
- W4317630247 hasConcept C2779690655 @default.
- W4317630247 hasConcept C2780727368 @default.
- W4317630247 hasConcept C3013748606 @default.
- W4317630247 hasConcept C51785407 @default.
- W4317630247 hasConcept C54355233 @default.
- W4317630247 hasConcept C86803240 @default.
- W4317630247 hasConcept C8891405 @default.
- W4317630247 hasConceptScore W4317630247C140704245 @default.
- W4317630247 hasConceptScore W4317630247C1491633281 @default.
- W4317630247 hasConceptScore W4317630247C159047783 @default.