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• W4317631254 abstract "Background: Single nucleotide polymorphisms provide information on individuals’ potential reactions to environmental factors, infections, diseases, as well as various therapies. A study on SNPs that influence SARS-CoV-2 susceptibility and severity may provide a predictive tool for COVID-19 outcomes and improve the customized coronavirus treatment. Aim: To evaluate the role of human leukocyte antigens DP/DQ and IFNλ4 polymorphisms on COVID-19 outcomes among Egyptian patients. Participants and Methods: The study involved 80 patients with severe COVID-19, 80 patients with mild COVID-19, and 80 non-infected healthy volunteers. Genotyping and allelic discrimination of HLA-DPrs3077 (G/A), HLA-DQrs7453920 (A/G), and IFNλ4 rs73555604 (C/T) SNPs were performed using real-time PCR. Results: Ages were 47.9 ± 8, 44.1 ± 12.1, and 45.8 ± 10 years in severe, mild and non-infected persons. There was a statistically significant association between severe COVID-19 and male gender ( p = 0.002). A statistically significant increase in the frequency of HLA-DPrs3077G, HLA-DQrs7453920A, and IFNλ4rs73555604C alleles among severe COVID-19 patients when compared with other groups ( p &lt; 0.001). Coexistence of these alleles in the same individual increases the susceptibility to severe COVID-19 by many folds ( p &lt; 0.001). Univariate and multivariate logistic regression analysis for the studied parameters showed that old age, male gender, non-vaccination, HLA-DQ rs7453920AG+AA, HLA-DPrs3077GA+GG, and IFNλ4rs73555604CT+CC genotypes are independent risk factors for severe COVID-19 among Egyptian patients. Conclusion : HLA-DQ rs7453920A, HLA-DPrs3077G, and IFNλ4rs73555604C alleles could be used as markers of COVID-19 severity." @default.
• W4317631254 created "2023-01-21" @default.
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• W4317631254 date "2023-01-20" @default.
• W4317631254 modified "2023-09-26" @default.
• W4317631254 title "Relevance of HLA-DP/DQ and INF-λ4 Polymorphisms to COVID-19 Outcomes" @default.
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• W4317631254 doi "https://doi.org/10.3389/bjbs.2023.11044" @default.
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• W4317631254 hasPublicationYear "2023" @default.
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