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- W4317639293 abstract "An unusual case of a patient with Goodpasture’s disease presenting with hemoptysis, severe iron deficiency anemia and microscopic hematuria and proteinuria is described. Both circulating and tissue anti-glomerular basement membrane (GBM) antibodies were present, and renal function remained normal throughout. Immunosuppressive therapy was given for subclinical pulmonary hemorrhage with successful resolution of anemia and disappearance of the circulating anti-GBM antibody. Nine months after presentation he developed nephrotic range proteinuria and a repeat renal biopsy revealed membranous glomerulonephdtis with no evidence of his original disease. Both the Goodpasture’s associated HLA-DR2 and the membranous associated HLA-DR3 class 11 antigens were present. The association of antibody mediated and immune complex glomerulonephritis is discussed. The simultaneous presence of HLA-DR2 and HLA-DR3 may predispose to this association. An unusual case of a patient with Goodpasture’s disease presenting with hemoptysis, severe iron deficiency anemia and microscopic hematuria and proteinuria is described. Both circulating and tissue anti-glomerular basement membrane (GBM) antibodies were present, and renal function remained normal throughout. Immunosuppressive therapy was given for subclinical pulmonary hemorrhage with successful resolution of anemia and disappearance of the circulating anti-GBM antibody. Nine months after presentation he developed nephrotic range proteinuria and a repeat renal biopsy revealed membranous glomerulonephdtis with no evidence of his original disease. Both the Goodpasture’s associated HLA-DR2 and the membranous associated HLA-DR3 class 11 antigens were present. The association of antibody mediated and immune complex glomerulonephritis is discussed. The simultaneous presence of HLA-DR2 and HLA-DR3 may predispose to this association." @default.
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- W4317639293 date "1995-01-01" @default.
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- W4317639293 title "Progression from Goodpasture’s disease to membranous glomerulonephritis" @default.
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- W4317639293 doi "https://doi.org/10.1080/00313029500169043" @default.
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