Matches in SemOpenAlex for { <https://semopenalex.org/work/W4317640150> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W4317640150 endingPage "843???851" @default.
- W4317640150 startingPage "843???851" @default.
- W4317640150 abstract "Tolerance develops to caffeine-induced stimulation of both locomotor activity and rotational behavior. The role of dopamine in tolerance to the locomotor stimulant effects of caffeine has been documented. However, the role of dopamine in caffeine-induced turning behavior remains to be elucidated. Therefore, the present sturdy determined the role of dopamine receptors in tolerance to caffeine-induced rotational behavior. Rats with a unilateral lesion of the nigrostriatal tract, induced by 6-hydroxydopamine (6-OHDA), were treated chronically with either caffeine (1.0 mg/ml) or with drug-free tap water, by a method of scheduled access. Agonists with and without selectivity for dopamine receptor sub-types were tested in both groups of rats (nonselective: apomorphine, d-amphetamine; D1 selective: SKF-38393, SKF-77434; D2 selective: R(−)-propylnor-apomorphine (NPA), quinpirole). All drugs produced dose-dependent increases in turning that, with the exception of quinpirole, were comparable in both groups. Quinpirole produced a smaller effect in rats treated with caffeine than in control rats. Thus, there was significant cross-tolerance only to the effects of quinpirole. The concurrent administration of SKF-38393 with NPA produced a synergistic interaction on rotational behavior in control rats, to which cross-tolerance did not develop in caffeine-treated rats. In contrast to what occurs with locomotor activity, in control rats the selective D1 dopamine receptor antagonist SCH 23390 completely blocked SKF-38393-induced turning behavior and the selective D2 dopamine receptor antagonist eticlopride partially attenuated this effect. NPA-induced turning behavior was blocked only by eticlopride; SCH 23390 was without effect. Both SCH 23390 and eticlopride blocked d-amphetamine-induced rotational behavior. The results of this study suggest that D1 dopamine receptors are not involved in tolerance to caffeine-induced rotational behavior. The role of D2 dopamine receptors in this effect is unresolved. Results obtained from rotational behavior studies generally do not parallel those obtained from locomotor activity studies, suggesting that different mechanisms underlie the effects of caffeine on these two behaviors." @default.
- W4317640150 created "2023-01-21" @default.
- W4317640150 creator A5017191970 @default.
- W4317640150 creator A5058790605 @default.
- W4317640150 date "1995-12-01" @default.
- W4317640150 modified "2023-09-26" @default.
- W4317640150 title "The effects of dopamine agonists on rotational behavior in non-tolerant and caffeine-tolerant rats" @default.
- W4317640150 doi "https://doi.org/10.1097/00008877-199512000-00011" @default.
- W4317640150 hasPublicationYear "1995" @default.
- W4317640150 type Work @default.
- W4317640150 citedByCount "9" @default.
- W4317640150 countsByYear W43176401502015 @default.
- W4317640150 countsByYear W43176401502016 @default.
- W4317640150 crossrefType "journal-article" @default.
- W4317640150 hasAuthorship W4317640150A5017191970 @default.
- W4317640150 hasAuthorship W4317640150A5058790605 @default.
- W4317640150 hasConcept C120069818 @default.
- W4317640150 hasConcept C120750228 @default.
- W4317640150 hasConcept C126322002 @default.
- W4317640150 hasConcept C134018914 @default.
- W4317640150 hasConcept C137183658 @default.
- W4317640150 hasConcept C170493617 @default.
- W4317640150 hasConcept C185592680 @default.
- W4317640150 hasConcept C2776885963 @default.
- W4317640150 hasConcept C2777193897 @default.
- W4317640150 hasConcept C2777525119 @default.
- W4317640150 hasConcept C2778125517 @default.
- W4317640150 hasConcept C2778296116 @default.
- W4317640150 hasConcept C2778500429 @default.
- W4317640150 hasConcept C2778938600 @default.
- W4317640150 hasConcept C2779917531 @default.
- W4317640150 hasConcept C513476851 @default.
- W4317640150 hasConcept C55493867 @default.
- W4317640150 hasConcept C71924100 @default.
- W4317640150 hasConcept C98274493 @default.
- W4317640150 hasConceptScore W4317640150C120069818 @default.
- W4317640150 hasConceptScore W4317640150C120750228 @default.
- W4317640150 hasConceptScore W4317640150C126322002 @default.
- W4317640150 hasConceptScore W4317640150C134018914 @default.
- W4317640150 hasConceptScore W4317640150C137183658 @default.
- W4317640150 hasConceptScore W4317640150C170493617 @default.
- W4317640150 hasConceptScore W4317640150C185592680 @default.
- W4317640150 hasConceptScore W4317640150C2776885963 @default.
- W4317640150 hasConceptScore W4317640150C2777193897 @default.
- W4317640150 hasConceptScore W4317640150C2777525119 @default.
- W4317640150 hasConceptScore W4317640150C2778125517 @default.
- W4317640150 hasConceptScore W4317640150C2778296116 @default.
- W4317640150 hasConceptScore W4317640150C2778500429 @default.
- W4317640150 hasConceptScore W4317640150C2778938600 @default.
- W4317640150 hasConceptScore W4317640150C2779917531 @default.
- W4317640150 hasConceptScore W4317640150C513476851 @default.
- W4317640150 hasConceptScore W4317640150C55493867 @default.
- W4317640150 hasConceptScore W4317640150C71924100 @default.
- W4317640150 hasConceptScore W4317640150C98274493 @default.
- W4317640150 hasIssue "8" @default.
- W4317640150 hasLocation W43176401501 @default.
- W4317640150 hasOpenAccess W4317640150 @default.
- W4317640150 hasPrimaryLocation W43176401501 @default.
- W4317640150 hasRelatedWork W1541356587 @default.
- W4317640150 hasRelatedWork W1996048142 @default.
- W4317640150 hasRelatedWork W2009579516 @default.
- W4317640150 hasRelatedWork W2061834596 @default.
- W4317640150 hasRelatedWork W2065522211 @default.
- W4317640150 hasRelatedWork W2083948707 @default.
- W4317640150 hasRelatedWork W2141226507 @default.
- W4317640150 hasRelatedWork W2803831545 @default.
- W4317640150 hasRelatedWork W4252121113 @default.
- W4317640150 hasRelatedWork W2019654948 @default.
- W4317640150 hasVolume "6" @default.
- W4317640150 isParatext "false" @default.
- W4317640150 isRetracted "false" @default.
- W4317640150 workType "article" @default.