FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4317680959> ?p ?o ?g. }

• W4317680959 endingPage "106661" @default.
• W4317680959 startingPage "106661" @default.
• W4317680959 abstract "Hepatocellular carcinoma (HCC) is one of the leading causes of death, which deserves further study to reveal the underlying molecular mechanisms. Studies have shown that miR-9 in associated with poor prognosis in HCC patients. However, the mechanisms of transcriptional activation regulation of miR-9 and its role in the malignant progression of HCC have been rarely investigated. Some transcriptional coactivators can form phase-separated condensates at super-enhancers that compartmentalize and concentrate the transcription apparatus to drive robust gene expression. Here, we demonstrate that Twist1 and YY1 could form a transcriptional complex with p300, creating local high-concentration phase-separated interaction hubs at the super-enhancers of miR-9 and activate its expression to promote the malignant progression of HCC by stimulating the migration and invasion of hepatocellular carcinoma cells. Twist1-YY1-p300 phase-separated condensates were disrupted by metformin (Met) and thus reduce miR-9 expression, thereby inhibiting the malignant progression of HCC. Our study demonstrates that the Twist1 transcriptional factor complex involved in the malignant progression of HCC can form phase separation condensates at super-enhancers of miR-9 to promote the expression of oncogenes in HCC cells. It provides a potential target for the therapy of HCC and offers insights into the mechanism of Met in HCC inhibition." @default.
• W4317680959 created "2023-01-22" @default.
• W4317680959 creator A5008080020 @default.
• W4317680959 creator A5013811376 @default.
• W4317680959 creator A5017379979 @default.
• W4317680959 creator A5024778679 @default.
• W4317680959 creator A5025656038 @default.
• W4317680959 creator A5028960226 @default.
• W4317680959 creator A5037377007 @default.
• W4317680959 creator A5062277357 @default.
• W4317680959 creator A5068431389 @default.
• W4317680959 creator A5068715943 @default.
• W4317680959 creator A5069921704 @default.
• W4317680959 creator A5090932841 @default.
• W4317680959 date "2023-02-01" @default.
• W4317680959 modified "2023-10-18" @default.
• W4317680959 title "Twist1-YY1-p300 complex promotes the malignant progression of HCC through activation of miR-9 by forming phase-separated condensates at super-enhancers and relieved by metformin" @default.
• W4317680959 cites W1531821806 @default.
• W4317680959 cites W1648301895 @default.
• W4317680959 cites W1854281301 @default.
• W4317680959 cites W1900657670 @default.
• W4317680959 cites W1942239823 @default.
• W4317680959 cites W1966227037 @default.
• W4317680959 cites W1969466735 @default.
• W4317680959 cites W1986586739 @default.
• W4317680959 cites W2002395443 @default.
• W4317680959 cites W2015182899 @default.
• W4317680959 cites W2016360721 @default.
• W4317680959 cites W2036619779 @default.
• W4317680959 cites W2039309132 @default.
• W4317680959 cites W2045362835 @default.
• W4317680959 cites W2045813899 @default.
• W4317680959 cites W2050804976 @default.
• W4317680959 cites W2051463024 @default.
• W4317680959 cites W2056022574 @default.
• W4317680959 cites W2060484997 @default.
• W4317680959 cites W2067067252 @default.
• W4317680959 cites W2082414039 @default.
• W4317680959 cites W2085978470 @default.
• W4317680959 cites W2102707911 @default.
• W4317680959 cites W2120156669 @default.
• W4317680959 cites W2129265683 @default.
• W4317680959 cites W2151754128 @default.
• W4317680959 cites W2168602111 @default.
• W4317680959 cites W2170846478 @default.
• W4317680959 cites W2395905799 @default.
• W4317680959 cites W2402820423 @default.
• W4317680959 cites W2469912802 @default.
• W4317680959 cites W2494187022 @default.
• W4317680959 cites W2590568317 @default.
• W4317680959 cites W2603000633 @default.
• W4317680959 cites W2615607456 @default.
• W4317680959 cites W2756821926 @default.
• W4317680959 cites W2783489663 @default.
• W4317680959 cites W2788827529 @default.
• W4317680959 cites W2803801991 @default.
• W4317680959 cites W2806486243 @default.
• W4317680959 cites W2809057270 @default.
• W4317680959 cites W2809265915 @default.
• W4317680959 cites W2885811648 @default.
• W4317680959 cites W2888330909 @default.
• W4317680959 cites W2888538492 @default.
• W4317680959 cites W2897039855 @default.
• W4317680959 cites W2901209536 @default.
• W4317680959 cites W2903264039 @default.
• W4317680959 cites W2914544406 @default.
• W4317680959 cites W2914775587 @default.
• W4317680959 cites W2914907359 @default.
• W4317680959 cites W2919859489 @default.
• W4317680959 cites W2945648932 @default.
• W4317680959 cites W3044625941 @default.
• W4317680959 cites W3198688401 @default.
• W4317680959 cites W4210847638 @default.
• W4317680959 cites W4213057770 @default.
• W4317680959 cites W4292801236 @default.
• W4317680959 doi "https://doi.org/10.1016/j.phrs.2023.106661" @default.
• W4317680959 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36669583" @default.
• W4317680959 hasPublicationYear "2023" @default.
• W4317680959 type Work @default.
• W4317680959 citedByCount "4" @default.
• W4317680959 countsByYear W43176809592023 @default.
• W4317680959 crossrefType "journal-article" @default.
• W4317680959 hasAuthorship W4317680959A5008080020 @default.
• W4317680959 hasAuthorship W4317680959A5013811376 @default.
• W4317680959 hasAuthorship W4317680959A5017379979 @default.
• W4317680959 hasAuthorship W4317680959A5024778679 @default.
• W4317680959 hasAuthorship W4317680959A5025656038 @default.
• W4317680959 hasAuthorship W4317680959A5028960226 @default.
• W4317680959 hasAuthorship W4317680959A5037377007 @default.
• W4317680959 hasAuthorship W4317680959A5062277357 @default.
• W4317680959 hasAuthorship W4317680959A5068431389 @default.
• W4317680959 hasAuthorship W4317680959A5068715943 @default.
• W4317680959 hasAuthorship W4317680959A5069921704 @default.
• W4317680959 hasAuthorship W4317680959A5090932841 @default.
• W4317680959 hasBestOaLocation W43176809591 @default.
• W4317680959 hasConcept C101762097 @default.
• W4317680959 hasConcept C104317684 @default.
• W4317680959 hasConcept C111936080 @default.

• next