Matches in SemOpenAlex for { <https://semopenalex.org/work/W4317702919> ?p ?o ?g. }
- W4317702919 abstract "Abstract A-to-I RNA editing diversifies human transcriptome to confer its functional effects on the downstream genes or regulations, potentially involving in neurodegenerative pathogenesis. Its variabilities are attributed to multiple regulators, including the key factor of genetic variants. To comprehensively investigate the potentials of neurodegenerative disease-susceptibility variants from the view of A-to-I RNA editing, we analyzed matched genetic and transcriptomic data of 1596 samples across nine brain tissues and whole blood from two large consortiums, Accelerating Medicines Partnership-Alzheimer’s Disease and Parkinson’s Progression Markers Initiative. The large-scale and genome-wide identification of 95 198 RNA editing quantitative trait loci revealed the preferred genetic effects on adjacent editing events. Furthermore, to explore the underlying mechanisms of the genetic controls of A-to-I RNA editing, several top RNA-binding proteins were pointed out, such as EIF4A3, U2AF2, NOP58, FBL, NOP56 and DHX9, since their regulations on multiple RNA-editing events were probably interfered by these genetic variants. Moreover, these variants may also contribute to the variability of other molecular phenotypes associated with RNA editing, including the functions of 3 proteins, expressions of 277 genes and splicing of 449 events. All the analyses results shown in NeuroEdQTL (https://relab.xidian.edu.cn/NeuroEdQTL/) constituted a unique resource for the understanding of neurodegenerative pathogenesis from genotypes to phenotypes related to A-to-I RNA editing." @default.
- W4317702919 created "2023-01-22" @default.
- W4317702919 creator A5014102611 @default.
- W4317702919 creator A5026340829 @default.
- W4317702919 creator A5028218058 @default.
- W4317702919 creator A5030202287 @default.
- W4317702919 creator A5040883232 @default.
- W4317702919 creator A5048858126 @default.
- W4317702919 creator A5069380051 @default.
- W4317702919 date "2023-01-21" @default.
- W4317702919 modified "2023-09-28" @default.
- W4317702919 title "Genetic control of RNA editing in neurodegenerative disease" @default.
- W4317702919 cites W1533942137 @default.
- W4317702919 cites W1552820890 @default.
- W4317702919 cites W1867017208 @default.
- W4317702919 cites W1964895626 @default.
- W4317702919 cites W1986923087 @default.
- W4317702919 cites W1988494453 @default.
- W4317702919 cites W1999574084 @default.
- W4317702919 cites W2007626008 @default.
- W4317702919 cites W2014216846 @default.
- W4317702919 cites W2048612325 @default.
- W4317702919 cites W2063280109 @default.
- W4317702919 cites W2075605386 @default.
- W4317702919 cites W2100697281 @default.
- W4317702919 cites W2109969031 @default.
- W4317702919 cites W2117977572 @default.
- W4317702919 cites W2122358139 @default.
- W4317702919 cites W2126551936 @default.
- W4317702919 cites W2135006644 @default.
- W4317702919 cites W2140307399 @default.
- W4317702919 cites W2153760714 @default.
- W4317702919 cites W2157561436 @default.
- W4317702919 cites W2157752701 @default.
- W4317702919 cites W2161633633 @default.
- W4317702919 cites W2174602966 @default.
- W4317702919 cites W2192293591 @default.
- W4317702919 cites W2193739999 @default.
- W4317702919 cites W2266524792 @default.
- W4317702919 cites W2267092331 @default.
- W4317702919 cites W2280633723 @default.
- W4317702919 cites W2320983896 @default.
- W4317702919 cites W2345356016 @default.
- W4317702919 cites W2512481987 @default.
- W4317702919 cites W2566925032 @default.
- W4317702919 cites W2597894202 @default.
- W4317702919 cites W2604754546 @default.
- W4317702919 cites W2612881983 @default.
- W4317702919 cites W2764209301 @default.
- W4317702919 cites W2767891136 @default.
- W4317702919 cites W2792944991 @default.
- W4317702919 cites W2793509733 @default.
- W4317702919 cites W2802497454 @default.
- W4317702919 cites W2803902474 @default.
- W4317702919 cites W2885010351 @default.
- W4317702919 cites W2888328757 @default.
- W4317702919 cites W2898850833 @default.
- W4317702919 cites W2901303766 @default.
- W4317702919 cites W2909784611 @default.
- W4317702919 cites W2915985519 @default.
- W4317702919 cites W2924192915 @default.
- W4317702919 cites W2948095452 @default.
- W4317702919 cites W2949785910 @default.
- W4317702919 cites W2952686034 @default.
- W4317702919 cites W2965916589 @default.
- W4317702919 cites W2969996790 @default.
- W4317702919 cites W2977367243 @default.
- W4317702919 cites W2977383991 @default.
- W4317702919 cites W2982225121 @default.
- W4317702919 cites W2984302209 @default.
- W4317702919 cites W3000568989 @default.
- W4317702919 cites W3014459671 @default.
- W4317702919 cites W3019552881 @default.
- W4317702919 cites W3020572257 @default.
- W4317702919 cites W3027045752 @default.
- W4317702919 cites W3040220357 @default.
- W4317702919 cites W3098075345 @default.
- W4317702919 cites W3107322429 @default.
- W4317702919 cites W3119475910 @default.
- W4317702919 cites W3135380964 @default.
- W4317702919 cites W3215996938 @default.
- W4317702919 cites W4200077127 @default.
- W4317702919 cites W4200243840 @default.
- W4317702919 cites W4200539498 @default.
- W4317702919 cites W4212801715 @default.
- W4317702919 cites W4212838134 @default.
- W4317702919 cites W4226026001 @default.
- W4317702919 cites W4226119625 @default.
- W4317702919 cites W4281713767 @default.
- W4317702919 doi "https://doi.org/10.1093/bib/bbad007" @default.
- W4317702919 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36681936" @default.
- W4317702919 hasPublicationYear "2023" @default.
- W4317702919 type Work @default.
- W4317702919 citedByCount "1" @default.
- W4317702919 countsByYear W43177029192023 @default.
- W4317702919 crossrefType "journal-article" @default.
- W4317702919 hasAuthorship W4317702919A5014102611 @default.
- W4317702919 hasAuthorship W4317702919A5026340829 @default.
- W4317702919 hasAuthorship W4317702919A5028218058 @default.
- W4317702919 hasAuthorship W4317702919A5030202287 @default.