Matches in SemOpenAlex for { <https://semopenalex.org/work/W4317717485> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W4317717485 endingPage "809" @default.
- W4317717485 startingPage "801" @default.
- W4317717485 abstract "KW-6356 is an adenosine A2A receptor-selective antagonist and inverse agonist. We conducted 2 studies: study 6356-001 (no NCT number), a randomized, double-blind, placebo-controlled phase 1 trial of single ascending (1, 3, 10 mg) and multiple (6 mg once daily) oral doses of KW-6356 in healthy Japanese subjects; and study 6356-004 (NCT03830528), including a randomized, double-blind, placebo-controlled phase 1 trial of single ascending (21, 42, 60 mg) and multiple (24 mg once daily) oral doses of KW-6356, and a phase 1 open-label trial of multiple oral doses (6 mg once daily) of KW-6356 in healthy Japanese and White subjects, to evaluate the safety, tolerability, and pharmacokinetics of KW-6356. KW-6356 was well tolerated after administration of single doses of up to 60 mg and multiple doses of up to 24 mg once daily for 14 days. The pharmacokinetics of KW-6356 were linear after a single dose of up to 60 mg KW-6356. The mean terminal elimination half-life of KW-6356 ranged from 18.4 to 43.1 hours following administration of single doses of 1-60 mg. There was no clear difference in the safety or pharmacokinetics of KW-6356 between healthy Japanese and White subjects." @default.
- W4317717485 created "2023-01-23" @default.
- W4317717485 creator A5022261258 @default.
- W4317717485 creator A5033615279 @default.
- W4317717485 creator A5039273638 @default.
- W4317717485 creator A5051525632 @default.
- W4317717485 creator A5053218019 @default.
- W4317717485 creator A5076566239 @default.
- W4317717485 creator A5080224702 @default.
- W4317717485 creator A5080799931 @default.
- W4317717485 date "2023-01-22" @default.
- W4317717485 modified "2023-10-16" @default.
- W4317717485 title "Safety, Tolerability, and Pharmacokinetics of the Novel Adenosine A<sub>2A</sub> Antagonist/Inverse Agonist KW‐6356 Following Single and Multiple Oral Administration in Healthy Volunteers" @default.
- W4317717485 cites W1973621564 @default.
- W4317717485 cites W1986174590 @default.
- W4317717485 cites W2014583561 @default.
- W4317717485 cites W2056362627 @default.
- W4317717485 cites W2077109037 @default.
- W4317717485 cites W2094888594 @default.
- W4317717485 cites W2145954079 @default.
- W4317717485 cites W2157049173 @default.
- W4317717485 cites W2166211493 @default.
- W4317717485 cites W2591243125 @default.
- W4317717485 doi "https://doi.org/10.1002/cpdd.1222" @default.
- W4317717485 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36683291" @default.
- W4317717485 hasPublicationYear "2023" @default.
- W4317717485 type Work @default.
- W4317717485 citedByCount "1" @default.
- W4317717485 countsByYear W43177174852023 @default.
- W4317717485 crossrefType "journal-article" @default.
- W4317717485 hasAuthorship W4317717485A5022261258 @default.
- W4317717485 hasAuthorship W4317717485A5033615279 @default.
- W4317717485 hasAuthorship W4317717485A5039273638 @default.
- W4317717485 hasAuthorship W4317717485A5051525632 @default.
- W4317717485 hasAuthorship W4317717485A5053218019 @default.
- W4317717485 hasAuthorship W4317717485A5076566239 @default.
- W4317717485 hasAuthorship W4317717485A5080224702 @default.
- W4317717485 hasAuthorship W4317717485A5080799931 @default.
- W4317717485 hasConcept C112705442 @default.
- W4317717485 hasConcept C126322002 @default.
- W4317717485 hasConcept C142724271 @default.
- W4317717485 hasConcept C170493617 @default.
- W4317717485 hasConcept C197934379 @default.
- W4317717485 hasConcept C204787440 @default.
- W4317717485 hasConcept C27081682 @default.
- W4317717485 hasConcept C2776885963 @default.
- W4317717485 hasConcept C2777056448 @default.
- W4317717485 hasConcept C2778375690 @default.
- W4317717485 hasConcept C2778938600 @default.
- W4317717485 hasConcept C42219234 @default.
- W4317717485 hasConcept C71924100 @default.
- W4317717485 hasConcept C98274493 @default.
- W4317717485 hasConceptScore W4317717485C112705442 @default.
- W4317717485 hasConceptScore W4317717485C126322002 @default.
- W4317717485 hasConceptScore W4317717485C142724271 @default.
- W4317717485 hasConceptScore W4317717485C170493617 @default.
- W4317717485 hasConceptScore W4317717485C197934379 @default.
- W4317717485 hasConceptScore W4317717485C204787440 @default.
- W4317717485 hasConceptScore W4317717485C27081682 @default.
- W4317717485 hasConceptScore W4317717485C2776885963 @default.
- W4317717485 hasConceptScore W4317717485C2777056448 @default.
- W4317717485 hasConceptScore W4317717485C2778375690 @default.
- W4317717485 hasConceptScore W4317717485C2778938600 @default.
- W4317717485 hasConceptScore W4317717485C42219234 @default.
- W4317717485 hasConceptScore W4317717485C71924100 @default.
- W4317717485 hasConceptScore W4317717485C98274493 @default.
- W4317717485 hasIssue "8" @default.
- W4317717485 hasLocation W43177174851 @default.
- W4317717485 hasLocation W43177174852 @default.
- W4317717485 hasOpenAccess W4317717485 @default.
- W4317717485 hasPrimaryLocation W43177174851 @default.
- W4317717485 hasRelatedWork W1830687917 @default.
- W4317717485 hasRelatedWork W1966047811 @default.
- W4317717485 hasRelatedWork W2003042623 @default.
- W4317717485 hasRelatedWork W202460821 @default.
- W4317717485 hasRelatedWork W2030348591 @default.
- W4317717485 hasRelatedWork W2068849886 @default.
- W4317717485 hasRelatedWork W2074207917 @default.
- W4317717485 hasRelatedWork W2147606462 @default.
- W4317717485 hasRelatedWork W2329478898 @default.
- W4317717485 hasRelatedWork W4366822339 @default.
- W4317717485 hasVolume "12" @default.
- W4317717485 isParatext "false" @default.
- W4317717485 isRetracted "false" @default.
- W4317717485 workType "article" @default.