FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4317725823> ?p ?o ?g. }

• W4317725823 endingPage "140" @default.
• W4317725823 startingPage "140" @default.
• W4317725823 abstract "Antisolvent crystallization is commonly used in the formation of heat-sensitive compounds as it is the case for most active pharmaceutical ingredients. Membranes have the ability to control the antisolvent mass transfer to the reaction medium, providing excellent mixing that inhibits the formation of local supersaturations responsible for the undesired properties of the resulting crystals. Still, optimization of the operating conditions is required. This work investigates the impact of solution velocity, the effect of antisolvent composition, the temperature and gravity, using glycine-water-ethanol as a model crystallization system, and polypropylene flat sheet membranes. Results proved that in any condition, membranes were consistent in providing a narrow crystal size distribution (CSD) with coefficient of variation (CV) in the range of 0.5–0.6 as opposed to 0.7 obtained by batch and drop-by-drop crystallization. The prism-like shape of glycine crystals was maintained as well, but slightly altered when operating at a temperature of 35 °C with the appearance of smoother crystal edges. Finally, the mean crystal size was within 23 to 40 µm and did not necessarily follow a clear correlation with the solution velocities or antisolvent composition, but increased with the application of higher temperature or gravity resistance. Besides, the monoclinic form of α-glycine was perfectly maintained in all conditions. The results at each condition correlated directly with the antisolvent transmembrane flux that ranged between 0.0002 and 0.001 kg/m2. s. In conclusion, membrane antisolvent crystallization is a robust solution offering consistent crystal properties under optimal operating conditions." @default.
• W4317725823 created "2023-01-23" @default.
• W4317725823 creator A5029086563 @default.
• W4317725823 creator A5054134347 @default.
• W4317725823 creator A5078003594 @default.
• W4317725823 creator A5088895298 @default.
• W4317725823 date "2023-01-21" @default.
• W4317725823 modified "2023-09-27" @default.
• W4317725823 title "Key Parameters Impacting the Crystal Formation in Antisolvent Membrane-Assisted Crystallization" @default.
• W4317725823 cites W1974425653 @default.
• W4317725823 cites W2002719464 @default.
• W4317725823 cites W2020175320 @default.
• W4317725823 cites W2054882945 @default.
• W4317725823 cites W2081212134 @default.
• W4317725823 cites W2115756453 @default.
• W4317725823 cites W2139417013 @default.
• W4317725823 cites W2153629451 @default.
• W4317725823 cites W2156528189 @default.
• W4317725823 cites W2306155769 @default.
• W4317725823 cites W2328912296 @default.
• W4317725823 cites W2516700614 @default.
• W4317725823 cites W2537582526 @default.
• W4317725823 cites W2582342372 @default.
• W4317725823 cites W2591624183 @default.
• W4317725823 cites W2791234080 @default.
• W4317725823 cites W2897647273 @default.
• W4317725823 cites W2922421495 @default.
• W4317725823 cites W3004466736 @default.
• W4317725823 cites W3011706875 @default.
• W4317725823 cites W3021778498 @default.
• W4317725823 cites W3037548822 @default.
• W4317725823 cites W3044532042 @default.
• W4317725823 cites W3082187554 @default.
• W4317725823 cites W3088699008 @default.
• W4317725823 cites W3093024890 @default.
• W4317725823 cites W3111003162 @default.
• W4317725823 cites W3126832077 @default.
• W4317725823 cites W4200562036 @default.
• W4317725823 cites W4224217783 @default.
• W4317725823 cites W4224272310 @default.
• W4317725823 cites W4246765948 @default.
• W4317725823 cites W4296015783 @default.
• W4317725823 cites W4310438817 @default.
• W4317725823 doi "https://doi.org/10.3390/membranes13020140" @default.
• W4317725823 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36837643" @default.
• W4317725823 hasPublicationYear "2023" @default.
• W4317725823 type Work @default.
• W4317725823 citedByCount "1" @default.
• W4317725823 countsByYear W43177258232023 @default.
• W4317725823 crossrefType "journal-article" @default.
• W4317725823 hasAuthorship W4317725823A5029086563 @default.
• W4317725823 hasAuthorship W4317725823A5054134347 @default.
• W4317725823 hasAuthorship W4317725823A5078003594 @default.
• W4317725823 hasAuthorship W4317725823A5088895298 @default.
• W4317725823 hasBestOaLocation W43177258231 @default.
• W4317725823 hasConcept C115624301 @default.
• W4317725823 hasConcept C127413603 @default.
• W4317725823 hasConcept C185592680 @default.
• W4317725823 hasConcept C192562407 @default.
• W4317725823 hasConcept C199360897 @default.
• W4317725823 hasConcept C203036418 @default.
• W4317725823 hasConcept C26456737 @default.
• W4317725823 hasConcept C2781285689 @default.
• W4317725823 hasConcept C2781345722 @default.
• W4317725823 hasConcept C41008148 @default.
• W4317725823 hasConcept C41625074 @default.
• W4317725823 hasConcept C42360764 @default.
• W4317725823 hasConcept C43617362 @default.
• W4317725823 hasConcept C55493867 @default.
• W4317725823 hasConcept C61276311 @default.
• W4317725823 hasConcept C76155785 @default.
• W4317725823 hasConcept C8010536 @default.
• W4317725823 hasConceptScore W4317725823C115624301 @default.
• W4317725823 hasConceptScore W4317725823C127413603 @default.
• W4317725823 hasConceptScore W4317725823C185592680 @default.
• W4317725823 hasConceptScore W4317725823C192562407 @default.
• W4317725823 hasConceptScore W4317725823C199360897 @default.
• W4317725823 hasConceptScore W4317725823C203036418 @default.
• W4317725823 hasConceptScore W4317725823C26456737 @default.
• W4317725823 hasConceptScore W4317725823C2781285689 @default.
• W4317725823 hasConceptScore W4317725823C2781345722 @default.
• W4317725823 hasConceptScore W4317725823C41008148 @default.
• W4317725823 hasConceptScore W4317725823C41625074 @default.
• W4317725823 hasConceptScore W4317725823C42360764 @default.
• W4317725823 hasConceptScore W4317725823C43617362 @default.
• W4317725823 hasConceptScore W4317725823C55493867 @default.
• W4317725823 hasConceptScore W4317725823C61276311 @default.
• W4317725823 hasConceptScore W4317725823C76155785 @default.
• W4317725823 hasConceptScore W4317725823C8010536 @default.
• W4317725823 hasIssue "2" @default.
• W4317725823 hasLocation W43177258231 @default.
• W4317725823 hasLocation W43177258232 @default.
• W4317725823 hasLocation W43177258233 @default.
• W4317725823 hasOpenAccess W4317725823 @default.
• W4317725823 hasPrimaryLocation W43177258231 @default.
• W4317725823 hasRelatedWork W1538103397 @default.
• W4317725823 hasRelatedWork W1988195810 @default.
• W4317725823 hasRelatedWork W2002806631 @default.

• next