Matches in SemOpenAlex for { <https://semopenalex.org/work/W4317734075> ?p ?o ?g. }
- W4317734075 endingPage "360" @default.
- W4317734075 startingPage "360" @default.
- W4317734075 abstract "Glioblastoma multiforme (GBM) is the most common adult primary brain malignancy, with dismal survival rates of ~14.6 months. The current standard-of-care consists of surgical resection and chemoradiotherapy, however the treatment response is limited by factors such as tumour heterogeneity, treatment resistance, the blood–brain barrier, and immunosuppression. Several immunotherapies have undergone clinical development for GBM but demonstrated inadequate efficacy, yet future combinatorial approaches are likely to hold more promise. Olaparib is FDA-approved for BRCA-mutated advanced ovarian and breast cancer, and clinical studies have revealed its utility as a safe and efficacious radio- and chemo-sensitiser in GBM. The ability of Olaparib to enhance natural killer (NK) cell-mediated responses has been reported in prostate, breast, and lung cancer. This study examined its potential combination with NK cell therapies in GBM by firstly investigating the susceptibility of the GBM cell line T98G to NK cells and, secondly, examining whether Olaparib can sensitise T98G cells to NK cell-mediated responses. Here, we characterise the NK receptor ligand profile of T98G cells and demonstrate that Olaparib does not dampen T98G susceptibility to NK cells or elicit immunomodulatory effects on the function of NK cells. This study provides novel insights into the potential combination of Olaparib with NK cell therapies for GBM." @default.
- W4317734075 created "2023-01-23" @default.
- W4317734075 creator A5013584181 @default.
- W4317734075 creator A5016890096 @default.
- W4317734075 creator A5019613582 @default.
- W4317734075 creator A5029498999 @default.
- W4317734075 creator A5061857431 @default.
- W4317734075 creator A5061977572 @default.
- W4317734075 creator A5062786371 @default.
- W4317734075 creator A5067657634 @default.
- W4317734075 creator A5078178094 @default.
- W4317734075 creator A5078708407 @default.
- W4317734075 date "2023-01-20" @default.
- W4317734075 modified "2023-10-01" @default.
- W4317734075 title "Investigating the Effects of Olaparib on the Susceptibility of Glioblastoma Multiforme Tumour Cells to Natural Killer Cell-Mediated Responses" @default.
- W4317734075 cites W1492184352 @default.
- W4317734075 cites W1645098973 @default.
- W4317734075 cites W1748587426 @default.
- W4317734075 cites W1800095175 @default.
- W4317734075 cites W1859347062 @default.
- W4317734075 cites W1863751964 @default.
- W4317734075 cites W1963731169 @default.
- W4317734075 cites W1969464492 @default.
- W4317734075 cites W1970787895 @default.
- W4317734075 cites W1974423029 @default.
- W4317734075 cites W1974757602 @default.
- W4317734075 cites W1977362534 @default.
- W4317734075 cites W1994953238 @default.
- W4317734075 cites W1995733047 @default.
- W4317734075 cites W2009043731 @default.
- W4317734075 cites W2018311806 @default.
- W4317734075 cites W2037379549 @default.
- W4317734075 cites W2046701977 @default.
- W4317734075 cites W2060520161 @default.
- W4317734075 cites W2079767351 @default.
- W4317734075 cites W2080933544 @default.
- W4317734075 cites W2096287682 @default.
- W4317734075 cites W2105003620 @default.
- W4317734075 cites W2114843025 @default.
- W4317734075 cites W2118217096 @default.
- W4317734075 cites W2118401604 @default.
- W4317734075 cites W2120943145 @default.
- W4317734075 cites W2143561528 @default.
- W4317734075 cites W2147068163 @default.
- W4317734075 cites W2149441684 @default.
- W4317734075 cites W2150319141 @default.
- W4317734075 cites W2201929875 @default.
- W4317734075 cites W2572765595 @default.
- W4317734075 cites W2587333476 @default.
- W4317734075 cites W2610318517 @default.
- W4317734075 cites W2753621408 @default.
- W4317734075 cites W2766941260 @default.
- W4317734075 cites W2769630938 @default.
- W4317734075 cites W2790382909 @default.
- W4317734075 cites W2792338464 @default.
- W4317734075 cites W2804813718 @default.
- W4317734075 cites W2884306042 @default.
- W4317734075 cites W2889251157 @default.
- W4317734075 cites W2896521195 @default.
- W4317734075 cites W2899022735 @default.
- W4317734075 cites W2899578763 @default.
- W4317734075 cites W2903079493 @default.
- W4317734075 cites W2904307134 @default.
- W4317734075 cites W2905145431 @default.
- W4317734075 cites W2911943691 @default.
- W4317734075 cites W2921554746 @default.
- W4317734075 cites W2924806376 @default.
- W4317734075 cites W2937730750 @default.
- W4317734075 cites W2945093047 @default.
- W4317734075 cites W2950976842 @default.
- W4317734075 cites W2951280589 @default.
- W4317734075 cites W2958014316 @default.
- W4317734075 cites W2960535277 @default.
- W4317734075 cites W2964190913 @default.
- W4317734075 cites W2979781140 @default.
- W4317734075 cites W2981233955 @default.
- W4317734075 cites W2998493318 @default.
- W4317734075 cites W3001496296 @default.
- W4317734075 cites W3013641691 @default.
- W4317734075 cites W3018583760 @default.
- W4317734075 cites W3020135519 @default.
- W4317734075 cites W3039510521 @default.
- W4317734075 cites W3045946240 @default.
- W4317734075 cites W3046958019 @default.
- W4317734075 cites W3109330936 @default.
- W4317734075 cites W3112438478 @default.
- W4317734075 cites W3126505600 @default.
- W4317734075 cites W3129898554 @default.
- W4317734075 cites W3134920043 @default.
- W4317734075 cites W3168985770 @default.
- W4317734075 cites W3171571522 @default.
- W4317734075 cites W3175416687 @default.
- W4317734075 cites W3198558595 @default.
- W4317734075 cites W3211287456 @default.
- W4317734075 cites W3215593750 @default.
- W4317734075 cites W4214884515 @default.
- W4317734075 cites W4220775362 @default.
- W4317734075 cites W4225356740 @default.