Matches in SemOpenAlex for { <https://semopenalex.org/work/W4317734549> ?p ?o ?g. }
- W4317734549 endingPage "2202" @default.
- W4317734549 startingPage "2202" @default.
- W4317734549 abstract "Src homology-2 containing protein tyrosine phosphatase (SHP2), encoded by PTPN11, has been proven to participate in bone-related diseases, such as Noonan syndrome (NS), metachondromatosis and osteoarthritis. However, the mechanisms of SHP2 in bone remodeling and homeostasis maintenance are complex and undemonstrated. The abnormal expression of SHP2 can influence the differentiation and maturation of osteoblasts, osteoclasts and chondrocytes. Meanwhile, SHP2 mutations can act on the immune system, vasculature and nervous system, which in turn affect bone development and remodeling. Signaling pathways regulated by SHP2, such as mitogen-activated protein kinase (MAPK), Indian hedgehog (IHH) and phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/protein kinase B (AKT), are also involved in the proliferation, differentiation and migration of bone functioning cells. This review summarizes the recent advances of SHP2 on osteogenesis-related cells and niche cells in the bone marrow microenvironment. The phenotypic features of SHP2 conditional knockout mice and underlying mechanisms are discussed. The prospective applications of the current agonists or inhibitors that target SHP2 in bone-related diseases are also described. Full clarification of the role of SHP2 in bone remodeling will shed new light on potential treatment for bone related diseases." @default.
- W4317734549 created "2023-01-23" @default.
- W4317734549 creator A5009981614 @default.
- W4317734549 creator A5025616036 @default.
- W4317734549 creator A5056691974 @default.
- W4317734549 creator A5067417882 @default.
- W4317734549 creator A5073363137 @default.
- W4317734549 date "2023-01-22" @default.
- W4317734549 modified "2023-10-14" @default.
- W4317734549 title "The Cell-Specific Role of SHP2 in Regulating Bone Homeostasis and Regeneration Niches" @default.
- W4317734549 cites W1521920146 @default.
- W4317734549 cites W1547429075 @default.
- W4317734549 cites W1551260331 @default.
- W4317734549 cites W1674292201 @default.
- W4317734549 cites W1840983034 @default.
- W4317734549 cites W1976686436 @default.
- W4317734549 cites W1987159215 @default.
- W4317734549 cites W1995645285 @default.
- W4317734549 cites W1996274092 @default.
- W4317734549 cites W2009260606 @default.
- W4317734549 cites W2011854585 @default.
- W4317734549 cites W2024616219 @default.
- W4317734549 cites W2024932182 @default.
- W4317734549 cites W2036070691 @default.
- W4317734549 cites W2036169358 @default.
- W4317734549 cites W2043625750 @default.
- W4317734549 cites W2049554331 @default.
- W4317734549 cites W2051043424 @default.
- W4317734549 cites W2051560210 @default.
- W4317734549 cites W2058186735 @default.
- W4317734549 cites W2059774540 @default.
- W4317734549 cites W2061122212 @default.
- W4317734549 cites W2066376265 @default.
- W4317734549 cites W2066671159 @default.
- W4317734549 cites W2067955480 @default.
- W4317734549 cites W2069475583 @default.
- W4317734549 cites W2084070846 @default.
- W4317734549 cites W2085017200 @default.
- W4317734549 cites W2089254126 @default.
- W4317734549 cites W2091450174 @default.
- W4317734549 cites W2107556275 @default.
- W4317734549 cites W2108578539 @default.
- W4317734549 cites W2112913947 @default.
- W4317734549 cites W2113177177 @default.
- W4317734549 cites W2127615555 @default.
- W4317734549 cites W2138697615 @default.
- W4317734549 cites W2138895339 @default.
- W4317734549 cites W2143207096 @default.
- W4317734549 cites W2151860737 @default.
- W4317734549 cites W2156803578 @default.
- W4317734549 cites W2158572699 @default.
- W4317734549 cites W2169365832 @default.
- W4317734549 cites W2193505608 @default.
- W4317734549 cites W2290282561 @default.
- W4317734549 cites W2309012093 @default.
- W4317734549 cites W2315744837 @default.
- W4317734549 cites W2349910005 @default.
- W4317734549 cites W2437593330 @default.
- W4317734549 cites W2468923062 @default.
- W4317734549 cites W2491700311 @default.
- W4317734549 cites W2505310355 @default.
- W4317734549 cites W2560367415 @default.
- W4317734549 cites W2562818717 @default.
- W4317734549 cites W2606013561 @default.
- W4317734549 cites W2606199910 @default.
- W4317734549 cites W2663210070 @default.
- W4317734549 cites W2758808877 @default.
- W4317734549 cites W2765304780 @default.
- W4317734549 cites W2766483656 @default.
- W4317734549 cites W2766645907 @default.
- W4317734549 cites W2769631051 @default.
- W4317734549 cites W2775320826 @default.
- W4317734549 cites W2783574387 @default.
- W4317734549 cites W2783585403 @default.
- W4317734549 cites W2783659976 @default.
- W4317734549 cites W2790664419 @default.
- W4317734549 cites W2790973556 @default.
- W4317734549 cites W2796478999 @default.
- W4317734549 cites W2802212080 @default.
- W4317734549 cites W2803293375 @default.
- W4317734549 cites W2803801423 @default.
- W4317734549 cites W2805484014 @default.
- W4317734549 cites W2886805569 @default.
- W4317734549 cites W2892361598 @default.
- W4317734549 cites W2898518698 @default.
- W4317734549 cites W2900923606 @default.
- W4317734549 cites W2945868237 @default.
- W4317734549 cites W2982752074 @default.
- W4317734549 cites W2985596826 @default.
- W4317734549 cites W2986532907 @default.
- W4317734549 cites W3005457250 @default.
- W4317734549 cites W3007068541 @default.
- W4317734549 cites W3022559105 @default.
- W4317734549 cites W3023791694 @default.
- W4317734549 cites W3043645790 @default.
- W4317734549 cites W3083915579 @default.
- W4317734549 cites W3085717162 @default.
- W4317734549 cites W3092589286 @default.