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• W4317743485 abstract "Agitation is a commonly encountered stress for enzymes during all stages of production and application, but investigations that aim to improve their tolerance using topological engineering have yet to be reported. Here, the plastic-degrading enzyme IsPETase was cyclized in a range of topologies including a cyclic monomer, cyclic dimer and catenane using SpyTag/SpyCatcher technologies, and their tolerance towards different stresses including mechanical agitation was investigated. The cyclic dimer and catenane topologies were less susceptible to agitation-induced inactivation resulting in enhancement of polyethylene terephthalate (PET) degradation. While contrary to conventional belief, cyclic topologies did not improve tolerance of IsPETase towards heat or proteolytic treatment, the close proximity of active sites in the dimeric and catenane variants was found to enhance PET conversion into small soluble products. Together, these findings illustrate that it is worthwhile to explore the topology engineering of enzymes used in heterogeneous catalysis as it improves factors that are often overlooked in homogeneous catalysis studies." @default.
• W4317743485 created "2023-01-23" @default.
• W4317743485 creator A5006455134 @default.
• W4317743485 creator A5055511501 @default.
• W4317743485 date "2023-01-23" @default.
• W4317743485 modified "2023-09-25" @default.
• W4317743485 title "Investigating the effects of cyclic topology on the performance of a plastic degrading enzyme for polyethylene terephthalate degradation" @default.
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• W4317743485 doi "https://doi.org/10.1038/s41598-023-27780-4" @default.
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• W4317743485 hasPublicationYear "2023" @default.
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