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- W4317743670 abstract "Treatment discontinuation is a major challenge in routine clinical settings. Despite poor adherence to antipsychotic medication, long acting injectable (LAI) formulations are an underutilized option in psychotic disorders. Recently, an earlier and broader use of LAIs has been emphasized. However, few studies have evaluated the factors associated with LAI antipsychotic discontinuation in ordinary clinical practice. The main purpose of the present study was, therefore, to identify the factors associated with LAI discontinuation in a real-world setting. Patients in treatment with LAI antipsychotics were recruited. A Cox regression analysis was applied considering a 12-month follow-up period. Moreover, a Kaplan-Meier survival analysis was applied to compare the single treatment LAI antipsychotic groups in terms of time to discontinuation. Our analysis showed an LAI discontinuation rate at 12 months, corresponding to 28.8%, with olanzapine and aripiprazole having a longer time to discontinuation compared to zuclopenthixol. The results of the present study can help clinicians with their choice of LAI antipsychotic according to patients’ characteristics and in a context of precision medicine. Increasing knowledge about factors affecting discontinuation of LAI antipsychotics can improve the prescribing practices of these compounds. Individualized approaches may ameliorate long-term patients’ treatment adherence, thus preventing the long-term disability caused by psychotic disorders." @default.
- W4317743670 created "2023-01-23" @default.
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- W4317743670 date "2023-01-22" @default.
- W4317743670 modified "2023-10-12" @default.
- W4317743670 title "High Rate of Discontinuation during Long-Acting Injectable Antipsychotic Treatment in Patients with Psychotic Disorders" @default.
- W4317743670 cites W1565231669 @default.
- W4317743670 cites W1573330233 @default.
- W4317743670 cites W1890298184 @default.
- W4317743670 cites W1995566889 @default.
- W4317743670 cites W2004252407 @default.
- W4317743670 cites W2008463165 @default.
- W4317743670 cites W2009832071 @default.
- W4317743670 cites W2012479321 @default.
- W4317743670 cites W2028902836 @default.
- W4317743670 cites W2033552074 @default.
- W4317743670 cites W2041474698 @default.
- W4317743670 cites W2046199879 @default.
- W4317743670 cites W2057464084 @default.
- W4317743670 cites W2062567955 @default.
- W4317743670 cites W2092173202 @default.
- W4317743670 cites W2101207510 @default.
- W4317743670 cites W2106655295 @default.
- W4317743670 cites W2124646619 @default.
- W4317743670 cites W2134675761 @default.
- W4317743670 cites W2143285031 @default.
- W4317743670 cites W2152259889 @default.
- W4317743670 cites W2153827064 @default.
- W4317743670 cites W2167451596 @default.
- W4317743670 cites W2294975593 @default.
- W4317743670 cites W2421854174 @default.
- W4317743670 cites W2476725984 @default.
- W4317743670 cites W2508582388 @default.
- W4317743670 cites W2509998784 @default.
- W4317743670 cites W2527103551 @default.
- W4317743670 cites W2588868824 @default.
- W4317743670 cites W2589762405 @default.
- W4317743670 cites W2592490726 @default.
- W4317743670 cites W2594212608 @default.
- W4317743670 cites W2604955719 @default.
- W4317743670 cites W2623053349 @default.
- W4317743670 cites W2736017503 @default.
- W4317743670 cites W2756227090 @default.
- W4317743670 cites W2778613387 @default.
- W4317743670 cites W2801804534 @default.
- W4317743670 cites W2809223684 @default.
- W4317743670 cites W2885040384 @default.
- W4317743670 cites W2887742515 @default.
- W4317743670 cites W2892043316 @default.
- W4317743670 cites W2892753330 @default.
- W4317743670 cites W2897341379 @default.
- W4317743670 cites W2906391346 @default.
- W4317743670 cites W2914982106 @default.
- W4317743670 cites W2937646155 @default.
- W4317743670 cites W2940332174 @default.
- W4317743670 cites W2965659331 @default.
- W4317743670 cites W2968948701 @default.
- W4317743670 cites W2983122039 @default.
- W4317743670 cites W2991489461 @default.
- W4317743670 cites W2993292446 @default.
- W4317743670 cites W3004899445 @default.
- W4317743670 cites W3009127448 @default.
- W4317743670 cites W3019591675 @default.
- W4317743670 cites W3029731088 @default.
- W4317743670 cites W3046669787 @default.
- W4317743670 cites W3048452840 @default.
- W4317743670 cites W3092763989 @default.
- W4317743670 cites W3092952627 @default.
- W4317743670 cites W3112869235 @default.
- W4317743670 cites W3116783343 @default.
- W4317743670 cites W3125120603 @default.
- W4317743670 cites W3127005125 @default.
- W4317743670 cites W3130350057 @default.
- W4317743670 cites W3141109455 @default.
- W4317743670 cites W3149233635 @default.
- W4317743670 cites W3158683193 @default.
- W4317743670 cites W3186113567 @default.
- W4317743670 cites W3197225468 @default.
- W4317743670 cites W4200040027 @default.
- W4317743670 cites W4220691202 @default.
- W4317743670 cites W4221099920 @default.
- W4317743670 cites W4224861393 @default.
- W4317743670 cites W4226334291 @default.
- W4317743670 cites W4229026417 @default.
- W4317743670 cites W4232880596 @default.
- W4317743670 cites W4247665917 @default.
- W4317743670 cites W4289711142 @default.
- W4317743670 cites W4295845721 @default.
- W4317743670 cites W4306253754 @default.
- W4317743670 doi "https://doi.org/10.3390/biomedicines11020314" @default.
- W4317743670 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36830850" @default.