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- W4317746722 endingPage "176" @default.
- W4317746722 startingPage "176" @default.
- W4317746722 abstract "T helper 22 (Th22) cells, a newly defined CD4+ T-cell lineage, are characterized by their distinct cytokine profile, which primarily consists of IL-13, IL-22 and TNF-α. Th22 cells express a wide spectrum of chemokine receptors, such as CCR4, CCR6 and CCR10. The main effector molecule secreted by Th22 cells is IL-22, a member of the IL-10 family, which acts by binding to IL-22R and triggering a complex downstream signaling system. Th22 cells and IL-22 have been found to play variable roles in human immunity. In preventing the progression of infections such as HIV and influenza, Th22/IL-22 exhibited protective anti-inflammatory characteristics, and their deleterious proinflammatory activities have been demonstrated to exacerbate other illnesses, including hepatitis B and Helicobacter pylori infection. Herein, we review the current understanding of Th22 cells, including their definition, differentiation and mechanisms, and the effect of Th22/IL-22 on human infectious diseases. According to studies on Th22 cells, Th22/IL-22 may be a promising therapeutic target and an effective treatment strategy for various infections." @default.
- W4317746722 created "2023-01-23" @default.
- W4317746722 creator A5000726024 @default.
- W4317746722 creator A5010738468 @default.
- W4317746722 creator A5030551898 @default.
- W4317746722 creator A5083553643 @default.
- W4317746722 creator A5086062422 @default.
- W4317746722 date "2023-01-23" @default.
- W4317746722 modified "2023-10-14" @default.
- W4317746722 title "Current Knowledge of Th22 Cell and IL-22 Functions in Infectious Diseases" @default.
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