Matches in SemOpenAlex for { <https://semopenalex.org/work/W4317751977> ?p ?o ?g. }
- W4317751977 abstract "Antimicrobial resistance was investigated in 2,341 nontyphoidal Salmonella (NTS) isolates recovered from humans in Taiwan from 2017 to 2018 using antimicrobial susceptibility testing. Azithromycin resistance determinants were detected in 175 selected isolates using PCR and confirmed in 81 selected isolates using whole-genome sequencing. Multidrug resistance was found in 47.3% of total isolates and 96.2% of Salmonella enterica serovar Anatum and 81.7% of S. enterica serovar Typhimurium isolates. Resistance to the conventional first-line drugs (ampicillin, chloramphenicol, and cotrimoxazole), cefotaxime and ceftazidime, and ciprofloxacin was found in 32.5 to 49.0%, 20.3 to 20.4%, and 3.2% of isolates, respectively. A total of 76 (3.1%) isolates were resistant to azithromycin, which was associated with mph(A), erm(42), erm(B), and possibly the enhanced expression of efflux pump(s) due to ramAp or defective ramR. mph(A) was found in 53% of the 76 azithromycin-resistant isolates from 11 serovars and located in an IS26-mph(A)-mrx(A)-mphR(A)-IS6100 unit in various incompatibility plasmids and the chromosomes. erm(42) in S. enterica serovar Albany was carried by an integrative and conjugative element, ICE_erm42, and in S. enterica serovar Enteritidis and S. Typhimurium was located in IS26 composite transposons in the chromosomes. erm(B) was carried by IncI1-I(α) plasmids in S. Enteritidis and S. Typhimurium. ramAp was a plasmid-borne ramA, a regulatory activator of efflux pump(s), found in only S. enterica serovar Goldcoast. Since the azithromycin resistance determinants are primarily carried on mobile genetic elements, they could easily be disseminated among human bacterial pathogens. The ramAp-carrying S. Goldcoast isolates displayed azithromycin MICs of 16 to 32 mg/L. Thus, the epidemiological cutoff value of ≤16 mg/L of azithromycin proposed for wild-type NTS should be reconsidered. IMPORTANCE Antimicrobial resistance in NTS isolates is a major public health concern in Taiwan, and the mechanisms of azithromycin resistance are rarely investigated. Azithromycin and carbapenems are the last resort for the treatment of invasive salmonellosis caused by multidrug-resistant (MDR) and extensively drug-resistant Salmonella strains. Our study reports the epidemiological trend of resistance in NTS in Taiwan and the genetic determinants involved in azithromycin resistance. We point out that nearly half of NTS isolates from 2017 to 2018 are MDR, and 20% are resistant to third-generation cephalosporins. The azithromycin resistance rate (3.1%) for the NTS isolates from Taiwan is much higher than those for the NTS isolates from the United States and Europe. Our study also indicates that azithromycin resistance is primarily mediated by mph(A), erm(42), erm(B), and ramAp, which are frequently carried on mobile genetic elements. Thus, the azithromycin resistance determinants could be expected to be disseminated among diverse bacterial pathogens." @default.
- W4317751977 created "2023-01-23" @default.
- W4317751977 creator A5011942756 @default.
- W4317751977 creator A5034479102 @default.
- W4317751977 creator A5037107863 @default.
- W4317751977 creator A5061993317 @default.
- W4317751977 creator A5067253876 @default.
- W4317751977 creator A5068578108 @default.
- W4317751977 creator A5072803763 @default.
- W4317751977 date "2023-02-14" @default.
- W4317751977 modified "2023-10-18" @default.
- W4317751977 title "Antimicrobial Resistance and Mechanisms of Azithromycin Resistance in Nontyphoidal Salmonella Isolates in Taiwan, 2017 to 2018" @default.
- W4317751977 cites W1553459312 @default.
- W4317751977 cites W1570691327 @default.
- W4317751977 cites W1910972311 @default.
- W4317751977 cites W1964509770 @default.
- W4317751977 cites W1967620589 @default.
- W4317751977 cites W1968520116 @default.
- W4317751977 cites W1983824101 @default.
- W4317751977 cites W1998159860 @default.
- W4317751977 cites W2001970448 @default.
- W4317751977 cites W2008359948 @default.
- W4317751977 cites W2014550970 @default.
- W4317751977 cites W2033558409 @default.
- W4317751977 cites W2046131957 @default.
- W4317751977 cites W2058550226 @default.
- W4317751977 cites W2097955745 @default.
- W4317751977 cites W2100034360 @default.
- W4317751977 cites W2101997581 @default.
- W4317751977 cites W2102898060 @default.
- W4317751977 cites W2114047144 @default.
- W4317751977 cites W2114796784 @default.
- W4317751977 cites W2114853012 @default.
- W4317751977 cites W2119845188 @default.
- W4317751977 cites W2122344148 @default.
- W4317751977 cites W2125882863 @default.
- W4317751977 cites W2127600795 @default.
- W4317751977 cites W2128066741 @default.
- W4317751977 cites W2128591134 @default.
- W4317751977 cites W2137941568 @default.
- W4317751977 cites W2142428670 @default.
- W4317751977 cites W2148074107 @default.
- W4317751977 cites W2151329247 @default.
- W4317751977 cites W2171076011 @default.
- W4317751977 cites W2172097617 @default.
- W4317751977 cites W2508752697 @default.
- W4317751977 cites W2539617131 @default.
- W4317751977 cites W2545359414 @default.
- W4317751977 cites W2621049936 @default.
- W4317751977 cites W2742345113 @default.
- W4317751977 cites W2792400256 @default.
- W4317751977 cites W2802475821 @default.
- W4317751977 cites W2902771940 @default.
- W4317751977 cites W2940090207 @default.
- W4317751977 cites W2950904154 @default.
- W4317751977 cites W2952167528 @default.
- W4317751977 cites W2966604140 @default.
- W4317751977 cites W2975535544 @default.
- W4317751977 cites W2985326047 @default.
- W4317751977 cites W3014037805 @default.
- W4317751977 cites W3037791019 @default.
- W4317751977 cites W3042408010 @default.
- W4317751977 cites W3048765603 @default.
- W4317751977 cites W3100227291 @default.
- W4317751977 cites W3131197084 @default.
- W4317751977 cites W3134896087 @default.
- W4317751977 cites W3136475225 @default.
- W4317751977 cites W3210126759 @default.
- W4317751977 cites W3216056331 @default.
- W4317751977 cites W4200435672 @default.
- W4317751977 cites W4205968867 @default.
- W4317751977 cites W4220660387 @default.
- W4317751977 cites W4220660916 @default.
- W4317751977 cites W4223533324 @default.
- W4317751977 cites W4226092504 @default.
- W4317751977 cites W4226176526 @default.
- W4317751977 cites W4229020888 @default.
- W4317751977 cites W4232096031 @default.
- W4317751977 cites W874637225 @default.
- W4317751977 doi "https://doi.org/10.1128/spectrum.03364-22" @default.
- W4317751977 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36688703" @default.
- W4317751977 hasPublicationYear "2023" @default.
- W4317751977 type Work @default.
- W4317751977 citedByCount "5" @default.
- W4317751977 countsByYear W43177519772023 @default.
- W4317751977 crossrefType "journal-article" @default.
- W4317751977 hasAuthorship W4317751977A5011942756 @default.
- W4317751977 hasAuthorship W4317751977A5034479102 @default.
- W4317751977 hasAuthorship W4317751977A5037107863 @default.
- W4317751977 hasAuthorship W4317751977A5061993317 @default.
- W4317751977 hasAuthorship W4317751977A5067253876 @default.
- W4317751977 hasAuthorship W4317751977A5068578108 @default.
- W4317751977 hasAuthorship W4317751977A5072803763 @default.
- W4317751977 hasBestOaLocation W43177519771 @default.
- W4317751977 hasConcept C10389963 @default.
- W4317751977 hasConcept C104317684 @default.
- W4317751977 hasConcept C114851261 @default.
- W4317751977 hasConcept C133936738 @default.
- W4317751977 hasConcept C159047783 @default.
- W4317751977 hasConcept C200082930 @default.