Matches in SemOpenAlex for { <https://semopenalex.org/work/W4317753404> ?p ?o ?g. }
- W4317753404 abstract "Abstract The issue of delayed wound healing or nonhealing in diabetic patients presents a challenge for modern medicine. A number of attempts have been made to understand the mechanisms behind diabetic wound. In a hyperglycemic environment, increased intracellular reactive oxygen species (ROS) disturb the balance between oxidation and antioxidant, causing the wound environment to deteriorate. It has been established that the nuclear factor E2-related factor 2 (Nrf2) and nuclear factor-kappa B (NF-κB) pathways play an important role in regulating inflammation and oxidative stress. Several potential treatment strategies involving Nrf2 and/or NF-κB pathways have been explored in previous studies. Hence, we analyzed mechanisms and changes in Nrf2 and NF-κB pathways in response to oxidative stress and inflammation in diabetic environment. Additionally, we reviewed potential treatment strategies from the past five years for diabetic wound by Nrf2 and/or NF-κB pathways, including receptor agonists, vitamins, hormones, exosomes, drugs, plants, and biomaterials. It may be useful to develop drugs to promote diabetic wound healing." @default.
- W4317753404 created "2023-01-23" @default.
- W4317753404 creator A5031831437 @default.
- W4317753404 creator A5062372916 @default.
- W4317753404 creator A5068045022 @default.
- W4317753404 creator A5065114898 @default.
- W4317753404 date "2023-01-23" @default.
- W4317753404 modified "2023-10-18" @default.
- W4317753404 title "Mechanisms of Nrf2 and NF-κB pathways in diabetic wound and potential treatment strategies" @default.
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