Matches in SemOpenAlex for { <https://semopenalex.org/work/W4317754300> ?p ?o ?g. }
- W4317754300 endingPage "154336" @default.
- W4317754300 startingPage "154336" @default.
- W4317754300 abstract "BRCA1 and BRCA2 are onco-suppressor genes involved in the DNA repair mechanism. The presence of BRCA1/2 mutations confers a higher risk of developing several cancer types. To date, the FDA approved various PARP inhibitors to treat selected BRCA1/2 mutated oncologic patients. At first, PARP inhibitors were approved for patients with ovarian and breast cancers, and subsequently for metastatic pancreatic adenocarcinoma and metastatic castration-resistant prostate cancer after the treatment with chemotherapy. The current guidelines for BRCA testing are very heterogeneous between the different types of tumors regarding the diagnostic algorithm and the type of sample to analyze, such as the blood for the germline mutations and the tumoral tissue for the somatic mutations. Few data have currently been described regarding the detection of BRCA1/2 somatic mutations in formalin-fixed paraffin-embedded (FFPE) samples. In this review, we propose an overview of the BRCA mutations in FFPE samples of several cancers, including breast, ovarian, fallopian tube, primary peritoneal, prostate, and pancreatic cancer. We summarize the types and the frequency of BRCA mutations, the guidelines approved for the test, the molecular assays used for the detection and the PARP inhibitors approved for each tumor type." @default.
- W4317754300 created "2023-01-23" @default.
- W4317754300 creator A5007917336 @default.
- W4317754300 creator A5008499144 @default.
- W4317754300 creator A5009130863 @default.
- W4317754300 creator A5022725527 @default.
- W4317754300 creator A5028284107 @default.
- W4317754300 creator A5043177546 @default.
- W4317754300 creator A5066976468 @default.
- W4317754300 creator A5067376970 @default.
- W4317754300 creator A5073368809 @default.
- W4317754300 creator A5078951970 @default.
- W4317754300 creator A5081591603 @default.
- W4317754300 date "2023-03-01" @default.
- W4317754300 modified "2023-10-06" @default.
- W4317754300 title "Implementation of BRCA mutations testing in formalin-fixed paraffin-embedded (FFPE) samples of different cancer types" @default.
- W4317754300 cites W1714977269 @default.
- W4317754300 cites W1871202334 @default.
- W4317754300 cites W1954515006 @default.
- W4317754300 cites W1968459259 @default.
- W4317754300 cites W1970383271 @default.
- W4317754300 cites W1979737127 @default.
- W4317754300 cites W1988637626 @default.
- W4317754300 cites W2016760769 @default.
- W4317754300 cites W2024661056 @default.
- W4317754300 cites W2026587982 @default.
- W4317754300 cites W2030093162 @default.
- W4317754300 cites W2032346580 @default.
- W4317754300 cites W2036083043 @default.
- W4317754300 cites W2037812436 @default.
- W4317754300 cites W2043741728 @default.
- W4317754300 cites W2044210218 @default.
- W4317754300 cites W2049127671 @default.
- W4317754300 cites W2051409228 @default.
- W4317754300 cites W2053690532 @default.
- W4317754300 cites W2053766582 @default.
- W4317754300 cites W2056062576 @default.
- W4317754300 cites W2056472796 @default.
- W4317754300 cites W2062568878 @default.
- W4317754300 cites W2064497439 @default.
- W4317754300 cites W2071194784 @default.
- W4317754300 cites W2079932270 @default.
- W4317754300 cites W2081361425 @default.
- W4317754300 cites W2090740451 @default.
- W4317754300 cites W2091961739 @default.
- W4317754300 cites W2106157865 @default.
- W4317754300 cites W2111705409 @default.
- W4317754300 cites W2116284235 @default.
- W4317754300 cites W2118410764 @default.
- W4317754300 cites W2123113463 @default.
- W4317754300 cites W2124092811 @default.
- W4317754300 cites W2130875528 @default.
- W4317754300 cites W2133530320 @default.
- W4317754300 cites W2135914193 @default.
- W4317754300 cites W2137167442 @default.
- W4317754300 cites W2144031018 @default.
- W4317754300 cites W2153579158 @default.
- W4317754300 cites W2160475700 @default.
- W4317754300 cites W2162077547 @default.
- W4317754300 cites W2164324841 @default.
- W4317754300 cites W2164510297 @default.
- W4317754300 cites W2191632272 @default.
- W4317754300 cites W2237354940 @default.
- W4317754300 cites W2299537488 @default.
- W4317754300 cites W2332185934 @default.
- W4317754300 cites W2340335534 @default.
- W4317754300 cites W2462140105 @default.
- W4317754300 cites W2511515271 @default.
- W4317754300 cites W2516150042 @default.
- W4317754300 cites W2522369252 @default.
- W4317754300 cites W2523249025 @default.
- W4317754300 cites W2523859159 @default.
- W4317754300 cites W2527255307 @default.
- W4317754300 cites W2529709253 @default.
- W4317754300 cites W2530761807 @default.
- W4317754300 cites W2535231312 @default.
- W4317754300 cites W2551427875 @default.
- W4317754300 cites W2560322684 @default.
- W4317754300 cites W2627871710 @default.
- W4317754300 cites W2673776326 @default.
- W4317754300 cites W2727056237 @default.
- W4317754300 cites W2755955412 @default.
- W4317754300 cites W2774590220 @default.
- W4317754300 cites W2790920105 @default.
- W4317754300 cites W2792327545 @default.
- W4317754300 cites W2794128499 @default.
- W4317754300 cites W2794255277 @default.
- W4317754300 cites W2804512265 @default.
- W4317754300 cites W2888065522 @default.
- W4317754300 cites W2895036167 @default.
- W4317754300 cites W2945528112 @default.
- W4317754300 cites W2967331293 @default.
- W4317754300 cites W2972166775 @default.
- W4317754300 cites W2975372829 @default.
- W4317754300 cites W2982045840 @default.
- W4317754300 cites W3001210504 @default.
- W4317754300 cites W3010030389 @default.
- W4317754300 cites W3014383023 @default.