FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4317757110> ?p ?o ?g. }

• W4317757110 endingPage "104203" @default.
• W4317757110 startingPage "104203" @default.
• W4317757110 abstract "Berberine chloride (BER) is a benzylisoquinoline alkaloid known for its antihypertensive, antihyperglycemic, antitumor, anti-inflammatory and antioxidant activities. BER has limited absorption from the gastrointestinal tract due to self-aggregation, P-glycoprotein-mediated efflux and hepatobiliary re-excretion; therefore, its oral bioavailability is very low. The aim of this study is to develop BER loaded chitosan nanoparticles (BER-NPs) in order to increase the oral bioavailability and gastrointestinal stability of BER. BER-NPs were prepared by ionotropic gelation method. In order to characterize the formulation, encapsulation efficiency, particle size, polydispersity index and zeta potential were determined. At the end of the analysis the encapsulation efficiency was found to be 31.5 ± 0.4%, the zeta potential 41.6 ± 0.8 mV, the particle size 406 ± 25 nm and the polydispersity index was 0.462 ± 0.105. BER-NPs were also morphologically visualized by transmission electron microscopy (TEM) and characterized by Fourier transform infrared spectroscopy (FT-IR) and differential scanning calorimetry (DSC) analysis. In addition, solubility, dissolution and partition coefficient of BER and BER-NPs were determined and evaluated. In the in vitro drug release study, it was observed that BER was initially released rapidly from the formulation and then the release continued in a controlled manner. Stability studies have shown that BER-NPs increase the stability of BER in simulated gastrointestinal fluids. In addition, long term stability analyses were also performed and it was found that it would be appropriate to store BER-NPs at 5 °C ± 3 °C. The maximum plasma concentration (Cmax) for BER-NPs was found to be 32.7 ± 3.0 ng/mL in in vivo experiments in rats. The relative bioavailability of BER-NPs was calculated as 122.06%." @default.
• W4317757110 created "2023-01-23" @default.
• W4317757110 creator A5008536859 @default.
• W4317757110 creator A5028584347 @default.
• W4317757110 creator A5031104058 @default.
• W4317757110 creator A5085312737 @default.
• W4317757110 date "2023-02-01" @default.
• W4317757110 modified "2023-10-17" @default.
• W4317757110 title "Chitosan nanoparticles as promising tool for berberine delivery: Formulation, characterization and in vivo evaluation" @default.
• W4317757110 cites W1834073155 @default.
• W4317757110 cites W1964348907 @default.
• W4317757110 cites W1971645600 @default.
• W4317757110 cites W1973195425 @default.
• W4317757110 cites W1975530828 @default.
• W4317757110 cites W2026543323 @default.
• W4317757110 cites W2031732745 @default.
• W4317757110 cites W2038231515 @default.
• W4317757110 cites W2042849731 @default.
• W4317757110 cites W2051759959 @default.
• W4317757110 cites W2073299869 @default.
• W4317757110 cites W2085105898 @default.
• W4317757110 cites W2148156003 @default.
• W4317757110 cites W2180467040 @default.
• W4317757110 cites W2266732512 @default.
• W4317757110 cites W2272399875 @default.
• W4317757110 cites W2306267508 @default.
• W4317757110 cites W2466408871 @default.
• W4317757110 cites W2624073866 @default.
• W4317757110 cites W2737772033 @default.
• W4317757110 cites W2777871900 @default.
• W4317757110 cites W2803000067 @default.
• W4317757110 cites W2807920649 @default.
• W4317757110 cites W2898849725 @default.
• W4317757110 cites W2924395156 @default.
• W4317757110 cites W2969931990 @default.
• W4317757110 cites W299190129 @default.
• W4317757110 cites W3093777584 @default.
• W4317757110 cites W3133387003 @default.
• W4317757110 cites W3136919756 @default.
• W4317757110 cites W3150006120 @default.
• W4317757110 cites W3209738867 @default.
• W4317757110 cites W4210533673 @default.
• W4317757110 cites W4210974162 @default.
• W4317757110 doi "https://doi.org/10.1016/j.jddst.2023.104203" @default.
• W4317757110 hasPublicationYear "2023" @default.
• W4317757110 type Work @default.
• W4317757110 citedByCount "1" @default.
• W4317757110 countsByYear W43177571102023 @default.
• W4317757110 crossrefType "journal-article" @default.
• W4317757110 hasAuthorship W4317757110A5008536859 @default.
• W4317757110 hasAuthorship W4317757110A5028584347 @default.
• W4317757110 hasAuthorship W4317757110A5031104058 @default.
• W4317757110 hasAuthorship W4317757110A5085312737 @default.
• W4317757110 hasConcept C11432220 @default.
• W4317757110 hasConcept C121332964 @default.
• W4317757110 hasConcept C13965031 @default.
• W4317757110 hasConcept C147789679 @default.
• W4317757110 hasConcept C155672457 @default.
• W4317757110 hasConcept C171250308 @default.
• W4317757110 hasConcept C178790620 @default.
• W4317757110 hasConcept C181389837 @default.
• W4317757110 hasConcept C185592680 @default.
• W4317757110 hasConcept C187530423 @default.
• W4317757110 hasConcept C192562407 @default.
• W4317757110 hasConcept C2779732960 @default.
• W4317757110 hasConcept C39519442 @default.
• W4317757110 hasConcept C43617362 @default.
• W4317757110 hasConcept C71924100 @default.
• W4317757110 hasConcept C86181022 @default.
• W4317757110 hasConcept C97355855 @default.
• W4317757110 hasConcept C98274493 @default.
• W4317757110 hasConceptScore W4317757110C11432220 @default.
• W4317757110 hasConceptScore W4317757110C121332964 @default.
• W4317757110 hasConceptScore W4317757110C13965031 @default.
• W4317757110 hasConceptScore W4317757110C147789679 @default.
• W4317757110 hasConceptScore W4317757110C155672457 @default.
• W4317757110 hasConceptScore W4317757110C171250308 @default.
• W4317757110 hasConceptScore W4317757110C178790620 @default.
• W4317757110 hasConceptScore W4317757110C181389837 @default.
• W4317757110 hasConceptScore W4317757110C185592680 @default.
• W4317757110 hasConceptScore W4317757110C187530423 @default.
• W4317757110 hasConceptScore W4317757110C192562407 @default.
• W4317757110 hasConceptScore W4317757110C2779732960 @default.
• W4317757110 hasConceptScore W4317757110C39519442 @default.
• W4317757110 hasConceptScore W4317757110C43617362 @default.
• W4317757110 hasConceptScore W4317757110C71924100 @default.
• W4317757110 hasConceptScore W4317757110C86181022 @default.
• W4317757110 hasConceptScore W4317757110C97355855 @default.
• W4317757110 hasConceptScore W4317757110C98274493 @default.
• W4317757110 hasLocation W43177571101 @default.
• W4317757110 hasOpenAccess W4317757110 @default.
• W4317757110 hasPrimaryLocation W43177571101 @default.
• W4317757110 hasRelatedWork W1505739641 @default.
• W4317757110 hasRelatedWork W2046280088 @default.
• W4317757110 hasRelatedWork W2088502203 @default.
• W4317757110 hasRelatedWork W2110192055 @default.
• W4317757110 hasRelatedWork W2154543322 @default.
• W4317757110 hasRelatedWork W2298630361 @default.

• next