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- W4317757467 endingPage "2006" @default.
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- W4317757467 abstract "Herein, we present a generalizable and versatile strategy to engineer synthetic DNA ligand-binding devices that can be programmed to load and release a specific ligand at a defined temperature. We do so by re-engineering two model DNA-based receptors: a triplex-forming bivalent DNA-based receptor that recognizes a specific DNA sequence and an ATP-binding aptamer. The temperature at which these receptors load/release their ligands can be finely modulated by controlling the entropy associated with the linker connecting the two ligand-binding domains. The availability of a set of receptors with tunable and reversible temperature dependence allows achieving complex load/release behavior such as sustained ligand release over a wide temperature range. Similar programmable thermo-responsive synthetic ligand-binding devices can be of utility in applications such as drug delivery and production of smart materials." @default.
- W4317757467 created "2023-01-23" @default.
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- W4317757467 date "2023-01-23" @default.
- W4317757467 modified "2023-09-26" @default.
- W4317757467 title "Thermo-Programmed Synthetic DNA-Based Receptors" @default.
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- W4317757467 doi "https://doi.org/10.1021/acsnano.2c07039" @default.
- W4317757467 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36689298" @default.
- W4317757467 hasPublicationYear "2023" @default.
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