FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4317759499> ?p ?o ?g. }

• W4317759499 endingPage "e0280551" @default.
• W4317759499 startingPage "e0280551" @default.
• W4317759499 abstract "The CC genotype of the IFNL4 gene is known to be associated with increased Hepatitis C (HCV) cure rates with interferon-based therapy and may contribute to cure with direct acting antivirals. The Genedrive® IFNL4 is a CE marked Point of Care (PoC) molecular diagnostic test, designed for in vitro diagnostic use to provide rapid, real-time detection of IFNL4 genotype status for SNP rs12979860.120 Participants were consented to a substudy comparing IFNL4 genotyping results from a buccal swab analysed on the Genedrive® platform with results generated using the Affymetix UK Biobank array considered to be the gold standard.Buccal swabs were taken from 120 participants for PoC IFNL4 testing and a whole blood sample for genetic sequencing. Whole blood genotyping vs. buccal swab PoC testing identified 40 (33%), 65 (54%), and 15 (13%) had CC, CT and TT IFNL4 genotype respectively. The Buccal swab PoC identified 38 (32%) CC, 64 (53%) CT and 18 (15%) TT IFNL4 genotype respectively. The sensitivity and specificity of the buccal swab test to detect CC vs non-CC was 90% (95% CI 76-97%) and 98% (95% CI 91-100%) respectively.The buccal swab test was better at correctly identifying non-CC genotypes than CC genotypes. The high specificity of the Genedrive® assay prevents CT/TT genotypes being mistaken for CC, and could avoid patients being identified as potentially 'good responders' to interferon-based therapy." @default.
• W4317759499 created "2023-01-23" @default.
• W4317759499 creator A5001331694 @default.
• W4317759499 creator A5004138845 @default.
• W4317759499 creator A5007804720 @default.
• W4317759499 creator A5010873271 @default.
• W4317759499 creator A5021125833 @default.
• W4317759499 creator A5021731943 @default.
• W4317759499 creator A5026912922 @default.
• W4317759499 creator A5034416451 @default.
• W4317759499 creator A5036981869 @default.
• W4317759499 creator A5038465484 @default.
• W4317759499 creator A5047370734 @default.
• W4317759499 creator A5048256586 @default.
• W4317759499 creator A5056409369 @default.
• W4317759499 creator A5057195076 @default.
• W4317759499 creator A5065221186 @default.
• W4317759499 creator A5072310535 @default.
• W4317759499 creator A5073460580 @default.
• W4317759499 creator A5078318283 @default.
• W4317759499 creator A5088166199 @default.
• W4317759499 creator A5091276903 @default.
• W4317759499 date "2023-01-23" @default.
• W4317759499 modified "2023-09-27" @default.
• W4317759499 title "Utility of a buccal swab point-of-care test for the IFNL4 genotype in the era of direct acting antivirals for hepatitis C virus" @default.
• W4317759499 cites W1561942429 @default.
• W4317759499 cites W2021857044 @default.
• W4317759499 cites W2022687771 @default.
• W4317759499 cites W2063285149 @default.
• W4317759499 cites W2142298409 @default.
• W4317759499 cites W2577711539 @default.
• W4317759499 cites W2602069236 @default.
• W4317759499 cites W2753159425 @default.
• W4317759499 cites W2765847689 @default.
• W4317759499 cites W2772398344 @default.
• W4317759499 cites W3027689934 @default.
• W4317759499 cites W3121794507 @default.
• W4317759499 cites W4211243282 @default.
• W4317759499 doi "https://doi.org/10.1371/journal.pone.0280551" @default.
• W4317759499 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36689413" @default.
• W4317759499 hasPublicationYear "2023" @default.
• W4317759499 type Work @default.
• W4317759499 citedByCount "0" @default.
• W4317759499 crossrefType "journal-article" @default.
• W4317759499 hasAuthorship W4317759499A5001331694 @default.
• W4317759499 hasAuthorship W4317759499A5004138845 @default.
• W4317759499 hasAuthorship W4317759499A5007804720 @default.
• W4317759499 hasAuthorship W4317759499A5010873271 @default.
• W4317759499 hasAuthorship W4317759499A5021125833 @default.
• W4317759499 hasAuthorship W4317759499A5021731943 @default.
• W4317759499 hasAuthorship W4317759499A5026912922 @default.
• W4317759499 hasAuthorship W4317759499A5034416451 @default.
• W4317759499 hasAuthorship W4317759499A5036981869 @default.
• W4317759499 hasAuthorship W4317759499A5038465484 @default.
• W4317759499 hasAuthorship W4317759499A5047370734 @default.
• W4317759499 hasAuthorship W4317759499A5048256586 @default.
• W4317759499 hasAuthorship W4317759499A5056409369 @default.
• W4317759499 hasAuthorship W4317759499A5057195076 @default.
• W4317759499 hasAuthorship W4317759499A5065221186 @default.
• W4317759499 hasAuthorship W4317759499A5072310535 @default.
• W4317759499 hasAuthorship W4317759499A5073460580 @default.
• W4317759499 hasAuthorship W4317759499A5078318283 @default.
• W4317759499 hasAuthorship W4317759499A5088166199 @default.
• W4317759499 hasAuthorship W4317759499A5091276903 @default.
• W4317759499 hasBestOaLocation W43177594991 @default.
• W4317759499 hasConcept C104317684 @default.
• W4317759499 hasConcept C126322002 @default.
• W4317759499 hasConcept C135763542 @default.
• W4317759499 hasConcept C159047783 @default.
• W4317759499 hasConcept C167871757 @default.
• W4317759499 hasConcept C195735259 @default.
• W4317759499 hasConcept C31467283 @default.
• W4317759499 hasConcept C54355233 @default.
• W4317759499 hasConcept C71924100 @default.
• W4317759499 hasConcept C86803240 @default.
• W4317759499 hasConcept C90924648 @default.
• W4317759499 hasConcept C98274493 @default.
• W4317759499 hasConceptScore W4317759499C104317684 @default.
• W4317759499 hasConceptScore W4317759499C126322002 @default.
• W4317759499 hasConceptScore W4317759499C135763542 @default.
• W4317759499 hasConceptScore W4317759499C159047783 @default.
• W4317759499 hasConceptScore W4317759499C167871757 @default.
• W4317759499 hasConceptScore W4317759499C195735259 @default.
• W4317759499 hasConceptScore W4317759499C31467283 @default.
• W4317759499 hasConceptScore W4317759499C54355233 @default.
• W4317759499 hasConceptScore W4317759499C71924100 @default.
• W4317759499 hasConceptScore W4317759499C86803240 @default.
• W4317759499 hasConceptScore W4317759499C90924648 @default.
• W4317759499 hasConceptScore W4317759499C98274493 @default.
• W4317759499 hasFunder F4320311904 @default.
• W4317759499 hasFunder F4320334626 @default.
• W4317759499 hasFunder F4320334783 @default.
• W4317759499 hasFunder F4320336039 @default.
• W4317759499 hasIssue "1" @default.
• W4317759499 hasLocation W43177594991 @default.
• W4317759499 hasLocation W43177594992 @default.
• W4317759499 hasLocation W43177594993 @default.
• W4317759499 hasLocation W43177594994 @default.

• next