Matches in SemOpenAlex for { <https://semopenalex.org/work/W4317762427> ?p ?o ?g. }
- W4317762427 abstract "Abstract The heterogeneity of colorectal cancer (CRC) contributes to substantial differences in patient response to standard therapies. The consensus molecular subtypes (CMS) of CRC is the most widely-used gene expression-based classification and has contributed to a better understanding of disease heterogeneity and prognosis. Nevertheless, CMS intratumoral heterogeneity restricts its clinical application, stressing the necessity of further characterizing the composition and architecture of CRC. Here, we used Spatial Transcriptomics (ST) in combination with single-cell RNA sequencing (scRNA-seq) to decipher the spatially resolved cellular and molecular composition of CRC. In addition to mapping the intratumoral heterogeneity of CMS and their microenvironment, we identified cell communication events in the tumor-stroma interface of CMS2 carcinomas. This includes tumor growth-inhibiting as well as -activating signatures, such as the potential regulation of the ETV4 transcriptional activity by DCN or the PLAU-PLAUR ligand-receptor interaction. Our data show the power of ST to bring the CMS-based classification of CRC to another level and thereby gain useful molecular insights for personalized therapy." @default.
- W4317762427 created "2023-01-23" @default.
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- W4317762427 date "2023-01-23" @default.
- W4317762427 modified "2023-10-01" @default.
- W4317762427 title "Charting the Heterogeneity of Colorectal Cancer Consensus Molecular Subtypes using Spatial Transcriptomics" @default.
- W4317762427 cites W1525899559 @default.
- W4317762427 cites W1904677861 @default.
- W4317762427 cites W1934094702 @default.
- W4317762427 cites W2033751993 @default.
- W4317762427 cites W2067253161 @default.
- W4317762427 cites W2071359561 @default.
- W4317762427 cites W2073723168 @default.
- W4317762427 cites W2090789702 @default.
- W4317762427 cites W2094176300 @default.
- W4317762427 cites W2095351055 @default.
- W4317762427 cites W2096045656 @default.
- W4317762427 cites W2107212237 @default.
- W4317762427 cites W210743834 @default.
- W4317762427 cites W2111188487 @default.
- W4317762427 cites W2114104545 @default.
- W4317762427 cites W2146511318 @default.
- W4317762427 cites W2157699260 @default.
- W4317762427 cites W2159675211 @default.
- W4317762427 cites W2166178545 @default.
- W4317762427 cites W2167978765 @default.
- W4317762427 cites W2214074259 @default.
- W4317762427 cites W2312281573 @default.
- W4317762427 cites W2345744951 @default.
- W4317762427 cites W2361876374 @default.
- W4317762427 cites W2398235143 @default.
- W4317762427 cites W2472255748 @default.
- W4317762427 cites W2586691160 @default.
- W4317762427 cites W2617865703 @default.
- W4317762427 cites W2788593837 @default.
- W4317762427 cites W2796691218 @default.
- W4317762427 cites W2800392236 @default.
- W4317762427 cites W2801015037 @default.
- W4317762427 cites W2803164733 @default.
- W4317762427 cites W2883814466 @default.
- W4317762427 cites W2889916101 @default.
- W4317762427 cites W2897044695 @default.
- W4317762427 cites W2899292206 @default.
- W4317762427 cites W2900531731 @default.
- W4317762427 cites W2908906089 @default.
- W4317762427 cites W2916297485 @default.
- W4317762427 cites W2925322596 @default.
- W4317762427 cites W2945784542 @default.
- W4317762427 cites W2946663348 @default.
- W4317762427 cites W2951158909 @default.
- W4317762427 cites W2952391626 @default.
- W4317762427 cites W2960078024 @default.
- W4317762427 cites W2964315448 @default.
- W4317762427 cites W2984472267 @default.
- W4317762427 cites W2989807288 @default.
- W4317762427 cites W2996713376 @default.
- W4317762427 cites W2997280954 @default.
- W4317762427 cites W3000546176 @default.
- W4317762427 cites W3007199577 @default.
- W4317762427 cites W3013423366 @default.
- W4317762427 cites W3022661528 @default.
- W4317762427 cites W3027774968 @default.
- W4317762427 cites W3030461077 @default.
- W4317762427 cites W3031674275 @default.
- W4317762427 cites W3043602140 @default.
- W4317762427 cites W3048953509 @default.
- W4317762427 cites W3111278897 @default.
- W4317762427 cites W3111537572 @default.
- W4317762427 cites W3120392574 @default.
- W4317762427 cites W3130224122 @default.
- W4317762427 cites W3136595794 @default.
- W4317762427 cites W3138055079 @default.
- W4317762427 cites W3154047008 @default.
- W4317762427 cites W3157330972 @default.
- W4317762427 cites W3162896844 @default.
- W4317762427 cites W3164692211 @default.
- W4317762427 cites W3165120573 @default.
- W4317762427 cites W3165759141 @default.
- W4317762427 cites W3175752499 @default.