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- W4317771282 endingPage "022003" @default.
- W4317771282 startingPage "022003" @default.
- W4317771282 abstract "The human Blood Brain Barrier (hBBB) is a complex cellular architecture separating the blood from the brain parenchyma. Its integrity and perfect functionality are essential for preventing neurotoxic plasma components and pathogens enter the brain. Although vital for preserving the correct brain activity, the low permeability of hBBB represents a huge impediment to treat mental and neurological disorders or to address brain tumors. Indeed, the vast majority of potential drug treatments are unable to reach the brain crossing the hBBB. On the other hand, hBBB integrity can be damaged or its permeability increase as a result of infections or in presence of neurodegenerative diseases. Currentin vitrosystems andin vivoanimal models used to study the molecular/drug transport mechanism through the hBBB have several intrinsic limitations that are difficult to overcome. In this scenario, Organ-on-Chip (OoC) models based on microfluidic technologies are considered promising innovative platforms that combine the handiness of anin vitromodel with the complexity of a living organ, while reducing time and costs. In this review, we focus on recent advances in OoCs for developing hBBB models, with the aim of providing the reader with a critical overview of the main guidelines to design and manufacture a hBBB-on-chip, whose compartments need to mimic the 'blood side' and 'brain side' of the barrier, to choose the cells types that are both representative and convenient, and to adequately evaluate the barrier integrity, stability, and functionality." @default.
- W4317771282 created "2023-01-24" @default.
- W4317771282 creator A5001811406 @default.
- W4317771282 creator A5036753801 @default.
- W4317771282 creator A5058423562 @default.
- W4317771282 creator A5059067847 @default.
- W4317771282 creator A5070636987 @default.
- W4317771282 creator A5074667681 @default.
- W4317771282 date "2023-02-14" @default.
- W4317771282 modified "2023-09-26" @default.
- W4317771282 title "Advancements in modelling human blood brain-barrier on a chip" @default.
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- W4317771282 doi "https://doi.org/10.1088/1758-5090/acb571" @default.
- W4317771282 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36689766" @default.