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- W4317774023 abstract "Abstract Background : Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic cause of chronic kidney disease (CKD) that requires dialysis. Knowing geographical clusters can be a critical point for early diagnosis, progression control and genetic counseling. The objective was to establish the prevalence, geographic location, and racial distribution of patients with ADPKD who underwent dialysis or kidney transplant in Colombia between 2015 and 2019. Methods : Cross-sectional study with data from the national registry of chronic kidney disease (NRCKD) managed by the High Cost Diseases Fund ( Cuenta de Alto Costo [CAC] in Spanish) between July 1, 2015, and June 30, 2019. Colombian residents who reported with CKD with or without renal replacement therapy (RRT) due to polycystic kidney disease were included. Crude and adjusted prevalence rates were estimated by state and city. Results: The ADPKD period prevalence was 9.81 per 100,000 people, there were 4.35 cases of RRT per 100,000 people, mean age 52.58 years (±13.21) and 52.78% women. Seventy-six patients were Afro-Colombians, 6 indigenous and 1 gypsy. A total of 46.07% began scheduled dialysis. The highest adjusted prevalence rate was in Valle del Cauca (6.55 cases per 100,000 people), followed by Risaralda , La Guajira and Amazonas . Regarding cities, Cali had the highest prevalence rate (9.38 cases per 100,000 people), followed by Pasto , Medellin and Bucaramanga . Conclusions: ADPKD prevalence is lower compared to Europe and USA, some states with higher prevalence will be objective to genetic prevalence study." @default.
- W4317774023 created "2023-01-24" @default.
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- W4317774023 date "2023-01-23" @default.
- W4317774023 modified "2023-10-06" @default.
- W4317774023 title "Autosomal dominant polycystic kidney disease in Colombia" @default.
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- W4317774023 doi "https://doi.org/10.21203/rs.3.rs-2464229/v1" @default.
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