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• W4317776461 abstract "We performed single-cell RNA-sequencing and T cell receptor clonotype tracking of breast and ovarian cancer patients treated with the CDK4/6 inhibitor ribociclib and PD-1 blockade. We highlight evidence of two orthogonal treatment-associated phenomena: expansion of T cell effector populations and promotion of T cell memory formation. Augmentation of the antitumor memory pool by ribociclib boosts the efficacy of subsequent PD-1 blockade in mouse models of melanoma and breast cancer, pointing toward sequential therapy as a potentially safe and synergistic strategy in patients." @default.
• W4317776461 created "2023-01-24" @default.
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• W4317776461 date "2023-01-23" @default.
• W4317776461 modified "2023-10-15" @default.
• W4317776461 title "PD-1 blockade and CDK4/6 inhibition augment nonoverlapping features of T cell activation in cancer" @default.
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• W4317776461 doi "https://doi.org/10.1084/jem.20220729" @default.
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• W4317776461 hasPublicationYear "2023" @default.
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