Matches in SemOpenAlex for { <https://semopenalex.org/work/W4317776836> ?p ?o ?g. }
- W4317776836 abstract "Despite the availability of licensed vaccines, influenza causes considerable morbidity and mortality worldwide. Current influenza vaccines elicit an immune response that primarily targets the head domain of the viral glycoprotein hemagglutinin (HA). Influenza viruses, however, readily evade this response by acquiring mutations in the head domain. While vaccines that target the more conserved HA stalk may circumvent this problem, low levels of antistalk antibodies are elicited by vaccination, possibly due to the poor accessibility of the stalk domain to B cell receptors. In this work, it is demonstrated that nanoparticles presenting HA in an inverted orientation generate tenfold higher antistalk antibody titers after a prime immunization and fivefold higher antistalk titers after a boost than nanoparticles displaying HA in its regular orientation. Moreover, nanoparticles presenting HA in an inverted orientation elicit a broader antistalk response that reduces mouse weight loss and improves survival after challenge to a greater extent than nanoparticles displaying HA in a regular orientation. Refocusing the antibody response toward conserved epitopes by controlling antigen orientation may enable the design of broadly protective nanovaccines targeting influenza viruses and other pathogens with pandemic potential." @default.
- W4317776836 created "2023-01-24" @default.
- W4317776836 creator A5003357270 @default.
- W4317776836 creator A5006332634 @default.
- W4317776836 creator A5015092469 @default.
- W4317776836 creator A5047507320 @default.
- W4317776836 creator A5058502607 @default.
- W4317776836 creator A5062029978 @default.
- W4317776836 creator A5062939266 @default.
- W4317776836 creator A5071125492 @default.
- W4317776836 creator A5071260070 @default.
- W4317776836 creator A5087643634 @default.
- W4317776836 date "2023-02-03" @default.
- W4317776836 modified "2023-10-12" @default.
- W4317776836 title "Nanovaccines Displaying the Influenza Virus Hemagglutinin in an Inverted Orientation Elicit an Enhanced Stalk‐Directed Antibody Response" @default.
- W4317776836 cites W1816587284 @default.
- W4317776836 cites W1968122979 @default.
- W4317776836 cites W1981678362 @default.
- W4317776836 cites W1989368177 @default.
- W4317776836 cites W2001089308 @default.
- W4317776836 cites W2002406378 @default.
- W4317776836 cites W2004114526 @default.
- W4317776836 cites W2004862635 @default.
- W4317776836 cites W2006840424 @default.
- W4317776836 cites W2014180504 @default.
- W4317776836 cites W2023388704 @default.
- W4317776836 cites W2026504801 @default.
- W4317776836 cites W2046182783 @default.
- W4317776836 cites W2055984914 @default.
- W4317776836 cites W2070601214 @default.
- W4317776836 cites W2076251336 @default.
- W4317776836 cites W2076665147 @default.
- W4317776836 cites W2080330697 @default.
- W4317776836 cites W2083368175 @default.
- W4317776836 cites W2095336525 @default.
- W4317776836 cites W2104391453 @default.
- W4317776836 cites W2114652184 @default.
- W4317776836 cites W2119611042 @default.
- W4317776836 cites W2123708888 @default.
- W4317776836 cites W2130737480 @default.
- W4317776836 cites W2136406328 @default.
- W4317776836 cites W2152617913 @default.
- W4317776836 cites W2154666710 @default.
- W4317776836 cites W2161609692 @default.
- W4317776836 cites W2188526495 @default.
- W4317776836 cites W2274976235 @default.
- W4317776836 cites W2334437992 @default.
- W4317776836 cites W2588930849 @default.
- W4317776836 cites W2785232134 @default.
- W4317776836 cites W2866458126 @default.
- W4317776836 cites W2938046908 @default.
- W4317776836 cites W2952600281 @default.
- W4317776836 cites W2980433193 @default.
- W4317776836 cites W2986662648 @default.
- W4317776836 cites W3043253729 @default.
- W4317776836 cites W3110769594 @default.
- W4317776836 cites W3133204332 @default.
- W4317776836 cites W3159643065 @default.
- W4317776836 cites W3201772361 @default.
- W4317776836 cites W4291157258 @default.
- W4317776836 doi "https://doi.org/10.1002/adhm.202202729" @default.
- W4317776836 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36689343" @default.
- W4317776836 hasPublicationYear "2023" @default.
- W4317776836 type Work @default.
- W4317776836 citedByCount "1" @default.
- W4317776836 countsByYear W43177768362023 @default.
- W4317776836 crossrefType "journal-article" @default.
- W4317776836 hasAuthorship W4317776836A5003357270 @default.
- W4317776836 hasAuthorship W4317776836A5006332634 @default.
- W4317776836 hasAuthorship W4317776836A5015092469 @default.
- W4317776836 hasAuthorship W4317776836A5047507320 @default.
- W4317776836 hasAuthorship W4317776836A5058502607 @default.
- W4317776836 hasAuthorship W4317776836A5062029978 @default.
- W4317776836 hasAuthorship W4317776836A5062939266 @default.
- W4317776836 hasAuthorship W4317776836A5071125492 @default.
- W4317776836 hasAuthorship W4317776836A5071260070 @default.
- W4317776836 hasAuthorship W4317776836A5087643634 @default.
- W4317776836 hasConcept C159047783 @default.
- W4317776836 hasConcept C159654299 @default.
- W4317776836 hasConcept C195616568 @default.
- W4317776836 hasConcept C203014093 @default.
- W4317776836 hasConcept C22070199 @default.
- W4317776836 hasConcept C22889606 @default.
- W4317776836 hasConcept C2522874641 @default.
- W4317776836 hasConcept C2777546802 @default.
- W4317776836 hasConcept C2778692840 @default.
- W4317776836 hasConcept C2780801004 @default.
- W4317776836 hasConcept C32611913 @default.
- W4317776836 hasConcept C7842527 @default.
- W4317776836 hasConcept C86803240 @default.
- W4317776836 hasConceptScore W4317776836C159047783 @default.
- W4317776836 hasConceptScore W4317776836C159654299 @default.
- W4317776836 hasConceptScore W4317776836C195616568 @default.
- W4317776836 hasConceptScore W4317776836C203014093 @default.
- W4317776836 hasConceptScore W4317776836C22070199 @default.
- W4317776836 hasConceptScore W4317776836C22889606 @default.
- W4317776836 hasConceptScore W4317776836C2522874641 @default.
- W4317776836 hasConceptScore W4317776836C2777546802 @default.
- W4317776836 hasConceptScore W4317776836C2778692840 @default.
- W4317776836 hasConceptScore W4317776836C2780801004 @default.