FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4317776907> ?p ?o ?g. }

• W4317776907 abstract "Abstract Although aging enhances atherosclerosis, we do not know if this occurs via alterations in circulating immune cells, lipid metabolism, vasculature, or adipose tissue. Here, we examined whether aging exerts a direct pro‐atherogenic effect on adipose tissue in mice. After demonstrating that aging augmented the inflammatory profile of visceral but not subcutaneous adipose tissue, we transplanted visceral fat from young or aged mice onto the right carotid artery of Ldlr −/− recipients. Aged fat transplants not only increased atherosclerotic plaque size with increased macrophage numbers in the adjacent carotid artery, but also in distal vascular territories, indicating that aging of the adipose tissue enhances atherosclerosis via secreted factors. By depleting macrophages from the visceral fat, we identified that adipose tissue macrophages are major contributors of the secreted factors. To identify these inflammatory factors, we found that aged fat transplants secreted increased levels of the inflammatory mediators TNFα, CXCL2, and CCL2, which synergized to promote monocyte chemotaxis. Importantly, the combined blockade of these inflammatory mediators impeded the ability of aged fat transplants to enhance atherosclerosis. In conclusion, our study reveals that aging enhances atherosclerosis via increased inflammation of visceral fat. Our study suggests that future therapies targeting the visceral fat may reduce atherosclerosis disease burden in the expanding older population." @default.
• W4317776907 created "2023-01-24" @default.
• W4317776907 creator A5000253301 @default.
• W4317776907 creator A5018716772 @default.
• W4317776907 creator A5026298390 @default.
• W4317776907 creator A5028923883 @default.
• W4317776907 creator A5031059930 @default.
• W4317776907 creator A5045520767 @default.
• W4317776907 creator A5053204257 @default.
• W4317776907 creator A5061235423 @default.
• W4317776907 creator A5066883682 @default.
• W4317776907 creator A5082358838 @default.
• W4317776907 creator A5082578832 @default.
• W4317776907 creator A5086131245 @default.
• W4317776907 date "2023-01-23" @default.
• W4317776907 modified "2023-10-14" @default.
• W4317776907 title "Age‐associated adipose tissue inflammation promotes monocyte chemotaxis and enhances atherosclerosis" @default.
• W4317776907 cites W1932046626 @default.
• W4317776907 cites W1975834028 @default.
• W4317776907 cites W1988123774 @default.
• W4317776907 cites W1997544440 @default.
• W4317776907 cites W2009707750 @default.
• W4317776907 cites W2010345740 @default.
• W4317776907 cites W2018794044 @default.
• W4317776907 cites W2024881317 @default.
• W4317776907 cites W2031047943 @default.
• W4317776907 cites W2040424567 @default.
• W4317776907 cites W2052554962 @default.
• W4317776907 cites W2056245899 @default.
• W4317776907 cites W2066529599 @default.
• W4317776907 cites W2074963908 @default.
• W4317776907 cites W2077792952 @default.
• W4317776907 cites W2079724669 @default.
• W4317776907 cites W2094669111 @default.
• W4317776907 cites W2096185296 @default.
• W4317776907 cites W2108887402 @default.
• W4317776907 cites W2109870340 @default.
• W4317776907 cites W2123811618 @default.
• W4317776907 cites W2126525177 @default.
• W4317776907 cites W2131250713 @default.
• W4317776907 cites W2139308694 @default.
• W4317776907 cites W2150906421 @default.
• W4317776907 cites W2151172917 @default.
• W4317776907 cites W2152037832 @default.
• W4317776907 cites W2153328565 @default.
• W4317776907 cites W2159245434 @default.
• W4317776907 cites W2165678812 @default.
• W4317776907 cites W2166769366 @default.
• W4317776907 cites W2264758825 @default.
• W4317776907 cites W2529648316 @default.
• W4317776907 cites W2562831699 @default.
• W4317776907 cites W2605674430 @default.
• W4317776907 cites W2611743631 @default.
• W4317776907 cites W2737249697 @default.
• W4317776907 cites W2757837983 @default.
• W4317776907 cites W2758507511 @default.
• W4317776907 cites W2765720783 @default.
• W4317776907 cites W2860743873 @default.
• W4317776907 cites W2891919070 @default.
• W4317776907 cites W2891983638 @default.
• W4317776907 cites W2905806283 @default.
• W4317776907 cites W2907471984 @default.
• W4317776907 cites W2918493059 @default.
• W4317776907 cites W2924101029 @default.
• W4317776907 cites W2932076084 @default.
• W4317776907 cites W2940124477 @default.
• W4317776907 cites W2955261360 @default.
• W4317776907 cites W2968162671 @default.
• W4317776907 cites W2981641889 @default.
• W4317776907 cites W2994737239 @default.
• W4317776907 cites W2997528927 @default.
• W4317776907 cites W3004337403 @default.
• W4317776907 cites W3022882962 @default.
• W4317776907 cites W3046449061 @default.
• W4317776907 cites W3047886418 @default.
• W4317776907 cites W3082526716 @default.
• W4317776907 cites W3085562695 @default.
• W4317776907 cites W3086779883 @default.
• W4317776907 cites W3214265581 @default.
• W4317776907 cites W4223485052 @default.
• W4317776907 cites W4317776907 @default.
• W4317776907 doi "https://doi.org/10.1111/acel.13783" @default.
• W4317776907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36683460" @default.
• W4317776907 hasPublicationYear "2023" @default.
• W4317776907 type Work @default.
• W4317776907 citedByCount "5" @default.
• W4317776907 countsByYear W43177769072023 @default.
• W4317776907 crossrefType "journal-article" @default.
• W4317776907 hasAuthorship W4317776907A5000253301 @default.
• W4317776907 hasAuthorship W4317776907A5018716772 @default.
• W4317776907 hasAuthorship W4317776907A5026298390 @default.
• W4317776907 hasAuthorship W4317776907A5028923883 @default.
• W4317776907 hasAuthorship W4317776907A5031059930 @default.
• W4317776907 hasAuthorship W4317776907A5045520767 @default.
• W4317776907 hasAuthorship W4317776907A5053204257 @default.
• W4317776907 hasAuthorship W4317776907A5061235423 @default.
• W4317776907 hasAuthorship W4317776907A5066883682 @default.
• W4317776907 hasAuthorship W4317776907A5082358838 @default.
• W4317776907 hasAuthorship W4317776907A5082578832 @default.
• W4317776907 hasAuthorship W4317776907A5086131245 @default.

• next